{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:55:17Z","timestamp":1787028917568,"version":"build-2736575974"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The use of a bipolar resectoscope has become popular due to the lower risk of hyponatremia. However, gynecologists might overlook the risk of water intoxication. Water intoxication is associated with the infusion of distending fluid. We were interested in the prediction of the infused distending fluid volume in the era of bipolar hysteroscopy. Thus, the aim of this study was to identify the predictors of the infused distending fluid volume for hysteroscopic myomectomy. Materials and Methods: All consecutive women who underwent monopolar (n = 45) or bipolar (n = 137) hysteroscopic myomectomy were reviewed. Results: Myoma diameter (cm, coefficient = 680 mL, 95% confidence interval (CI) = 334\u20131025 mL, p &lt;0.001) and bipolar hysteroscopy (coefficient = 1629 mL, 95% CI = 507\u20132752 mL, p = 0.005) were independent predictors of infused distending fluid volume. A myoma diameter \u22654.0 cm was the optimal cutoff value to predict the presence of &gt;5000 mL of infused distending fluid. One woman in the bipolar group developed life-threatening water intoxication. Conclusions: Myoma diameter is associated with an increase in infused distending fluid volume, especially for myomas \u22654 cm. Meticulous monitoring of the infused distension fluid volume is still crucial to avoid fluid overload during bipolar hysteroscopic myomectomy.<\/jats:p>","DOI":"10.3390\/medicina60091424","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T10:54:11Z","timestamp":1725015251000},"page":"1424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors of Infused Distending Fluid Volume in Hysteroscopic Myomectomy"],"prefix":"10.3390","volume":"60","author":[{"given":"Chia-Han","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao District, New Taipei 220216, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Far Eastern Memorial Hospital, Banqiao District, New Taipei 220216, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Fen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao District, New Taipei 220216, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6299-1888","authenticated-orcid":false,"given":"Hui-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao District, New Taipei 220216, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Hua","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao District, New Taipei 220216, Taiwan"},{"name":"Department of Industrial Management, Asia Eastern University of Science and Technology, New Taipei 220303, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-9564","authenticated-orcid":false,"given":"Sheng-Mou","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao District, New Taipei 220216, Taiwan"},{"name":"Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei 100226, Taiwan"},{"name":"Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan 320315, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Association of Gynecologic Laparoscopists (AAGL): Advancing Minimally Invasive Gynecology Worldwide (2012). AAGL practice report: Practice guidelines for the diagnosis and management of submucous leiomyomas. J. Minim. Invasive Gynecol., 19, 152\u2013171.","DOI":"10.1016\/j.jmig.2011.09.005"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists (2005). ACOG technology assessment in obstetrics and gynecology, number 4, August 2005: Hysteroscopy. Obstet. Gynecol., 106, 439\u2013442.","DOI":"10.1097\/00006250-200508000-00054"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0889-8545(21)00194-7","article-title":"Media and delivery systems","volume":"22","author":"Marlow","year":"1995","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/jhrs.JHRS_134_16","article-title":"A Prospective randomized study comparing unipolar versus bipolar hysteroscopic myomectomy in infertile women","volume":"10","author":"Kansal","year":"2017","journal-title":"J. Hum. Reprod. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1447-0756.2010.01244.x","article-title":"Biological effects of distension media in bipolar versus monopolar resectoscopic myomectomy: A randomized trial","volume":"36","author":"Darwish","year":"2010","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.fertnstert.2008.01.083","article-title":"A randomized trial comparing monopolar electrodes using glycine 1.5% with two different types of bipolar electrodes (TCRis, Versapoint) using saline, in hysteroscopic surgery","volume":"91","author":"Berg","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0029-7844(97)00006-9","article-title":"The effect of dilute vasopress in solution on the force needed for cervical dilatation: A randomized controlled trial","volume":"89","author":"Phillips","year":"1997","journal-title":"Obstet. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejogrb.2015.06.003","article-title":"Safety and efficacy of manual syringe infusion of distending media for hysteroscopic procedures: A case-control study","volume":"191","author":"Ting","year":"2015","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ting, W.H., Lin, H.H., and Hsiao, S.M. (2019). Manual versus pump infusion of distending media for hysteroscopic procedures: A randomized controlled trial. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-51252-3"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4097\/kjae.2011.60.6.440","article-title":"Extreme hyponatremia with moderate metabolic acidosis during hysteroscopic myomectomy\u2014A case report","volume":"60","author":"Jo","year":"2011","journal-title":"Korean J. Anesthesiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jclinane.2011.03.003","article-title":"Severe intraoperative hyponatremia associated with the absorption of irrigation fluid during hysteroscopic myomectomy: A case report","volume":"23","author":"Woo","year":"2011","journal-title":"J. Clin. Anesth."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.5811\/cpcem.2019.4.41878","article-title":"Operative hysteroscopy intravascular absorption syndrome causing hyponatremia with associated cerebral and pulmonary edema","volume":"3","author":"Elegante","year":"2019","journal-title":"Clin. Pract. Cases Emerg. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Liao, C.-Y., Lo, C.-H., Yu, M.-X., Chan, W.-H., Wei, K.-Y., Tseng, M.-F., and Wu, C.-C. (2020). Life-threatening acute water intoxication in a woman undergoing hysteroscopic myomectomy: A case report and review of the literature. BMC Womens Health, 20.","DOI":"10.1186\/s12905-020-0895-y"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jclinane.2003.03.010","article-title":"Noncardiogenic pulmonary edema and venous air embolus as complications of operative hysteroscopy","volume":"16","author":"Grove","year":"2004","journal-title":"J. Clin. Anesth."},{"key":"ref_15","first-page":"373","article-title":"Hypotonic and isotonic fluid overload as a complication of hysteroscopic procedures: Two case reports","volume":"76","author":"Vermelis","year":"2010","journal-title":"Minerva Anestesiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.tjog.2020.07.022","article-title":"Operative hysteroscopy intravascular absorption syndrome is more than just the gynecological transurethral resection of the prostate syndrome: A case series and literature review","volume":"59","author":"Wang","year":"2020","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.12891\/ceog19432014","article-title":"Monopolar versus bipolar device: Safety, feasibility, limits and perioperative complications in performing hysteroscopic myomectomy","volume":"41","author":"Litta","year":"2014","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_18","first-page":"QC11","article-title":"Comparative study between monopolar electrodes and bipolar electrodes in hysteroscopic surgery","volume":"9","author":"Tammam","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_19","unstructured":"Roethlisberger, F.J., and Dickson, W.J. (1939). Management and the Worker, Harvard University Press."},{"key":"ref_20","first-page":"363","article-title":"The \u2018Hawthorne effect\u2019\u2014What did the original Hawthorne studies actually show?","volume":"26","author":"Wickstrom","year":"2000","journal-title":"Scand. J. Work Environ. Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMc1812323","article-title":"Labor induction vs. Expectant management of low-risk pregnancy","volume":"379","author":"Davey","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jmig.2007.04.010","article-title":"Small-diameter hysteroscopy with Versapoint versus resectoscopy with a unipolar knife for the treatment of septate uterus: A prospective randomized study","volume":"14","author":"Colacurci","year":"2007","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/ajo.12410","article-title":"The impact of altering filling pressures in diagnostic outpatient hysteroscopy on the procedure completion rates and associated pain: A randomized double blind controlled trial","volume":"56","author":"Haggag","year":"2016","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ijgo.12247","article-title":"A randomized double-blind controlled trial of different filling pressures in operative outpatient hysteroscopy","volume":"139","author":"Haggag","year":"2017","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/jog.13293","article-title":"What should the optimal intrauterine pressure be during outpatient diagnostic hysteroscopy? A randomized comparative study","volume":"43","author":"Karaman","year":"2017","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/gyn.1992.8.1","article-title":"The effect of pressure on fluid absorption during endometrial ablation","volume":"8","author":"Garry","year":"1992","journal-title":"J. Gynecol. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10397-016-0983-z","article-title":"BSGE\/ESGE guideline on management of fluid distension media in operative hysteroscopy","volume":"13","author":"Umranikar","year":"2016","journal-title":"Gynecol. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1093\/eurheartj\/ehu293","article-title":"Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors","volume":"35","author":"Herbert","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/bja\/68.2.151","article-title":"Fluid absorption during laser ablation of the endometrium in the treatment of menorrhagia","volume":"68","author":"Hasham","year":"1992","journal-title":"Br. J.Anaesth."},{"key":"ref_30","first-page":"51","article-title":"Safe and effective fluid management by automated gravitation during hysteroscopy","volume":"2","author":"Tomazevic","year":"1998","journal-title":"J. Soc. Laparoendosc. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jmig.2012.12.012","article-title":"Case-control study of complications associated with bipolar and monopolar hysteroscopic operations","volume":"20","author":"Bahar","year":"2013","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jmig.2017.06.014","article-title":"Reducing fluid-related complications during operative hysteroscopy: Use of a new mandatory fluid-balance form","volume":"24","author":"Alexandroni","year":"2017","journal-title":"J. Minim. Invasive Gynecol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/9\/1424\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:46:01Z","timestamp":1760111161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/9\/1424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["medicina60091424"],"URL":"https:\/\/doi.org\/10.3390\/medicina60091424","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]}}}