{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:36:46Z","timestamp":1790854606733,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Victor Babes University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: This study investigates the relationship between thyroid eye disease (TED) and open-angle glaucoma (OAG), focusing on disease severity and clinical features. Materials and Methods: Conducted at the Timis County Emergency Clinical Hospital, the research included 106 patients, with 53 having both conditions and 53 having only OAG. Key metrics analyzed included intraocular pressure (IOP) using a Goldmann applanation tonometer, the retinal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) characteristics evaluated using optical coherence tomography (OCT). Results: Results indicated that patients with both TED and OAG experienced a 6.09% reduction in RNFL thickness and showed more rapid disease progression, with 48.35% having active TED. The mean IOP in TED patients was 27.5 \u00b1 4.9 mmHg, which was similar to those with only OAG. Demographic factors, including age and gender, influenced the clinical course and disease severity. Conclusions: These findings underscore the importance of specialized monitoring and treatment strategies for patients with coexisting TED and OAG to prevent vision loss.<\/jats:p>","DOI":"10.3390\/medicina60091430","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T03:45:21Z","timestamp":1725248721000},"page":"1430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Thyroid Eye Disease and Glaucoma: A Cross-Sectional Study Comparing Clinical Characteristics and Disease Severity"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-5438","authenticated-orcid":false,"given":"Laura Andreea","family":"Ghenciu","sequence":"first","affiliation":[{"name":"Department of Functional Sciences, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Center for Translational Research and Systems Medicine, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina Maria","family":"\u0218i\u0219u","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embriology, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-3340","authenticated-orcid":false,"given":"Emil Robert","family":"Stoicescu","sequence":"additional","affiliation":[{"name":"Field of Applied Engineering Sciences, Specialization Statistical Methods and Techniques in Health and Clinical Research, Faculty of Mechanics, \u2018Politehnica\u2019 University Timisoara, Mihai Viteazul Boulevard No. 1, 300222 Timisoara, Romania"},{"name":"Department of Radiology and Medical Imaging, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Research Center for Pharmaco-Toxicological Evaluations, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9118-9133","authenticated-orcid":false,"given":"Alexandra-Ioana","family":"D\u0103nil\u0103","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embriology, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-712X","authenticated-orcid":false,"given":"Roxana","family":"Iacob","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embriology, \u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Field of Applied Engineering Sciences, Specialization Statistical Methods and Techniques in Health and Clinical Research, Faculty of Mechanics, \u2018Politehnica\u2019 University Timisoara, Mihai Viteazul Boulevard No. 1, 300222 Timisoara, Romania"},{"name":"Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai-Alexandru","family":"S\u0103ndesc","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovidiu Alin","family":"Ha\u021began","sequence":"additional","affiliation":[{"name":"Discipline of Anatomy and Embriology, Medicine Faculty, Vasile Goldis\u201d Western University of Arad, Revolution Boulevard 94, 310025 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"A43","DOI":"10.1186\/1756-6614-6-S2-A43","article-title":"Etiopathogenesis of Graves-Basedow Disease: Where We Are and Where We Are Going","volume":"6","author":"Nauman","year":"2013","journal-title":"Thyroid Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s12020-017-1306-5","article-title":"Epidemiology, Management, and Outcomes of Graves\u2019 Disease\u2014Real Life Data","volume":"56","author":"Hussain","year":"2017","journal-title":"Endocrine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/s41433-024-02967-9","article-title":"The Changing Landscape of Thyroid Eye Disease: Current Clinical Advances and Future 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