{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:25:59Z","timestamp":1760145959097,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Fibrillinopathies have different phenotypic expression: Marfan-like skeleton features, MLSF; mitral valve prolapse syndrome, MVPS; MASS phenotype, M = mitral valve prolapse, MVP, A = aortic root dilation, S = skeletal features, and the second S = (cutaneous) striae; Marfan Syndrome, MS. The study had the following main objectives: the correlation between disc displacement, DD (a major sign for temporomandibular joint dysfunction, TMDs) on magnetic resonance imaging, MRI, and aortic Z score (a major sign for aortic root dilation) on echocardiography; the predictive value of DD towards aortic Z score. DD had 2 types of severity: DD with reduction (the mild type, DDwR), and DD without reduction (the severe type, DDwoR). Materials and Methods: The type of fibrillinopathy was precised by clinical exam (systemic score), ophthalmic exam (for ectopia lentis), and echocardiography (aortic Z score, MVP). Medical treatment consisted of betablockers, BB (for patients with tachycardia), or angiotensin II receptor blockers, ARB. Surgical treatment was addressed to aortic root aneurysm, and severe mitral regurgitation, MR. DD benefited from dental conservatory treatment or surgical restoration. Results: DD-Z score had a powerful correlation in MASS (Rho = 0.787, p &lt; 0.01), and in MS patients (Rho = 0.819, p &lt; 0.01). For the entire sample, both DDwR-Z score and DDwoR-Z score had a moderate correlation (Rho = 0.469, and respectively 0.669). Furthermore, DD was an important predictor for Z score. DDwoR had a double power of prediction for the Z score compared with DDwR (B coefficient = 1.661 for DDwR and 3.281 for DDwoR). Conclusions: TMDs had a powerful correlation with aortic root dilation in MASS and MS patients from the sample. Likewise, TMDs was a major predictor for aortic root dilation, in the entire sample. In clinical practice, we can utilize an extracardiac finding, TMDs, obtained by a non-invasive technique, MRI, for cardiac severity stratification of fibrillinopathies.<\/jats:p>","DOI":"10.3390\/medicina60101572","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T16:16:37Z","timestamp":1727280997000},"page":"1572","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic Resonance Imaging of Temporomandibular Joint and Aortic Root Score in Fibrillinopathies"],"prefix":"10.3390","volume":"60","author":[{"given":"Paloma","family":"Moisii","sequence":"first","affiliation":[{"name":"1st Medical Department, \u201cGr.T.Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"\u201cPromedicanon\u201d Cardiology Office, 15 Valea Prisacii, Valea Lupului, 707410 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru Gratian","family":"Naum","sequence":"additional","affiliation":[{"name":"2nd Morpho-Functional Department, Biophysics and Medical Physics, \u201cGr.T.Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"\u201cNeolife\u201d Medical Center, 52 Carol I Avenue, 700503 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andra Mara","family":"Ursu","sequence":"additional","affiliation":[{"name":"Radiology and Medical Imaging Clinique, \u201cSf.Spiridon\u201dEmergency Hospital, 1st Independentei Avenue, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Vilcu","sequence":"additional","affiliation":[{"name":"Faculty of Industrial Design and Business Management, Department of Engineering and Management, \u201cGh.Asachi\u201d Technical University of Iasi, 700050 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5148-8769","authenticated-orcid":false,"given":"Irina","family":"Esanu","sequence":"additional","affiliation":[{"name":"1st Medical Department, \u201cGr.T.Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"\u201cC.F.\u201d Hospital Iasi, Medical Clinic, 1 Garabet Ibraileanu Street, 700506 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Jari","sequence":"additional","affiliation":[{"name":"Radiology and Medical Imaging Clinique, \u201cSf.Spiridon\u201dEmergency Hospital, 1st Independentei Avenue, 700111 Iasi, Romania"},{"name":"2nd Surgical Department, \u201cGr.T.Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"ref_1","unstructured":"Dietz, H., Adam, M.P., Feldman, J., Mirzaa, G.M., Pagon, R.A., Wallace, S.E., Bean, L.J.H., Gripp, K.W., and Amemiya, A. 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