{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:28:38Z","timestamp":1760146118649,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Graduate Studies and Scientific Research at Jouf University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background\/Objectives: Juvenile Open Angle Glaucoma (JOAG) is a condition that presents peculiar issues because it starts at a very early age and, in the end, causes substantial vision loss. This study aimed to analyze the age and gender distribution and treatment outcomes in JOAG patients. Methods: We carried out a retrospective study at King Abdul Aziz University Hospital, Riyadh, Saudi Arabia, from 2015 to 2022. We extracted data from the medical records. Visual acuity data were converted to the logarithm of the minimum angle resolution (LogMAR) for standardized analysis. The CARL ZEISS Humphrey 745i Field Analyzer\/HFA II-i Visual Field Analyzer was used to perform visual field examinations under the 24-2 program SITA standard. Results: The study involved 45 JOAG patients (87 affected eyes) with a mean age of 26.91 years. Myopia was the prevailing trait (93%), and a family history of glaucoma was found in 51.1% of cases. Most of the patients presented with severe visual field defects in both eyes (right\u201457.1%, left\u201444.4%). Regarding visual acuity, we found that the majority of affected categories belonged to either mild or moderate in both eyes. Initial and final Intraocular pressure (IOP) measurements together showed a significant reduction (p &lt; 0.001) and clearly demonstrated the need for IOP control. Surgical and non-surgical treatments significantly reduced IOP, with no gender or eye differences Conclusions: This research offers important data concerning JOAG demographics (age and gender), clinical picture, and treatment results. Though early-onset presents challenges, multidimensional therapeutic methods have great potential to get JOAG under control and maintain visual function. Additional research is needed to study the genetic causes of JOAG and assess the long-term treatment outcomes.<\/jats:p>","DOI":"10.3390\/medicina60101591","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T04:00:04Z","timestamp":1727668804000},"page":"1591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Age, Sex, and Clinical Characteristics of Juvenile Open-Angle Glaucoma Patients in a Saudi Tertiary Hospital: A Retrospective Study of Surgical and Non-Surgical Outcomes"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4957-514X","authenticated-orcid":false,"given":"Amar","family":"Almulhim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Al Jabr Eye and ENT Hospital, Ministry of Health, Al-Asha 36422, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5897-0163","authenticated-orcid":false,"given":"Abdulmohsen","family":"Almulhim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, College of Medicine, Jouf University, Sakaka 72388, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"ref_1","unstructured":"Dietze, J., Blair, K., and Havens, S.J. (2024). Glaucoma. StatPearls, StatPearls Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"key":"ref_3","unstructured":"Mahabadi, N., Foris, L.A., and Tripathy, K. (2024). Open Angle Glaucoma. StatPearls, StatPearls Publishing."},{"key":"ref_4","unstructured":"NEI (2024, March 15). Types of Glaucoma|National Eye Institute, Available online: https:\/\/www.nei.nih.gov\/learn-about-eye-health\/eye-conditions-and-diseases\/glaucoma\/types-glaucoma."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.survophthal.2021.09.001","article-title":"Juvenile-onset open-angle glaucoma\u2014A clinical and genetic update","volume":"67","author":"Selvan","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/08820530701745199","article-title":"Clinical and genetic characteristics of primary juvenile-onset open-angle glaucoma (JOAG)","volume":"23","author":"Turalba","year":"2008","journal-title":"Semin. Ophthalmol."},{"key":"ref_7","unstructured":"Chak, G., Mosaed, S., and Minckler, D. (2014). Diagnosing and Managing Juvenile Open-Angle Glaucoma, Gavin Herbert Eye Institute, University of California."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"El Sayed, Y.M., Elhusseiny, A.M., Gawdat, G.I., Esmael, A.F., and Elhilali, H.M. (2023). Childhood glaucoma profile in a tertiary centre in Egypt according to the childhood glaucoma research network classification. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0279874"},{"key":"ref_9","first-page":"a521","article-title":"Demographic and clinical characteristics of patients with glaucoma in a tertiary eye facility in Ghana","volume":"79","author":"Mashige","year":"2020","journal-title":"Afr. Vis. Eye Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/bjophthalmol-2019-314660","article-title":"Classifying juvenile onset primary open angle glaucoma using cluster analysis","volume":"104","author":"Shweta","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/ICU.0000000000000813","article-title":"Juvenile open angle glaucoma: Current diagnosis and management","volume":"33","author":"Ciociola","year":"2022","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_12","first-page":"1621-A0444","article-title":"Human neuritin 1: Therapeutic Strategy for Juvenile Open-Angle Glaucoma","volume":"63","author":"Miller","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_13","unstructured":"Shaarawy, T., and Grehn, F. (2009). Guidelines on Design and Reporting of Glaucoma Surgical Trials, Kugler Publications."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.sjopt.2011.09.001","article-title":"The profile of glaucoma in a Tertiary Ophthalmic University Center in Riyadh, Saudi Arabia","volume":"25","author":"Dewedar","year":"2011","journal-title":"Saudi J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3341\/kjo.2016.30.2.127","article-title":"Clinical Characteristics of Juvenile-onset Open Angle Glaucoma","volume":"30","author":"Kwun","year":"2016","journal-title":"Korean J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E1117","DOI":"10.1097\/OPX.0b013e3181b620d3","article-title":"Bilateral ocular hypertension with rapidly progressive optic neuropathy in a teen","volume":"86","author":"Hua","year":"2009","journal-title":"Optom. Vis. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ezinne, N.E., Ojukwu, C.S., Ekemiri, K.K., Akano, O.F., Ekure, E., and Osuagwu, U.L. (2021). Prevalence and clinical profile of glaucoma patients in rural Nigeria-A hospital based study. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0260965"},{"key":"ref_18","unstructured":"Jafer Chardoub, A.A., and Blair, K. (2024). Juvenile Glaucoma. StatPearls, StatPearls Publishing."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4103\/1119-3077.91742","article-title":"Demographic and clinical profile of patients with juvenile onset open angle glaucoma in southwestern Nigeria","volume":"14","author":"Komolafe","year":"2011","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2147\/TACG.S213818","article-title":"Genetic Analysis Of ABCA1 Gene Of Primary Glaucoma In Jordanian Arab Population","volume":"12","author":"Alkhatib","year":"2019","journal-title":"Appl. Clin. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.4103\/0301-4738.121064","article-title":"Determinants of severity at presentation among young patients with early onset glaucoma","volume":"61","author":"Gupta","year":"2013","journal-title":"Indian J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"(2017). European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition\u2014Chapter 3: Treatment principles and options; Supported by the EGS Foundation. Br. J. Ophthalmol., 101, 130.","DOI":"10.1136\/bjophthalmol-2016-EGSguideline.003"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.mayocpiqo.2022.09.007","article-title":"Updates on the Diagnosis and Management of Glaucoma","volume":"6","author":"Wagner","year":"2022","journal-title":"Mayo Clin. Proc. Innov. Qual. Outcomes"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1444-0938.2007.00241.x","article-title":"Bilateral juvenile open angle glaucoma in two Chinese children: Case report","volume":"91","author":"Ng","year":"2008","journal-title":"Clin. Exp. Optom."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/IJG.0000000000002334","article-title":"Efficacy and Safety of an Adjustable Glaucoma Drainage Device (eyeWatch System) for Refractory Glaucoma: A 2-Year Prospective Study","volume":"33","author":"Roy","year":"2024","journal-title":"J. Glaucoma"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/IJG.0000000000002217","article-title":"The Success Rate of Glaucoma Drainage Device Revision","volume":"32","author":"Bouris","year":"2023","journal-title":"J. Glaucoma"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5005\/jp-journals-10078-1267","article-title":"Characteristics of Pediatric Glaucoma in a Latin American Reference Center","volume":"14","author":"Saavedra","year":"2020","journal-title":"J. Curr. Glaucoma Pract."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Aktas, Z., and Gulpinar Ikiz, G.D. (2023). Current surgical techniques for the management of pediatric glaucoma: A literature review. Front. Ophthalmol., 3.","DOI":"10.3389\/fopht.2023.1101281"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.14744\/eer.2023.39306","article-title":"Surgical approaches to juvenile open-angle glaucoma","volume":"4","author":"Un","year":"2024","journal-title":"Eur. Eye Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/17469899.2017.1335597","article-title":"Microinvasive Glaucoma Surgery: An Evidence-Based Assessment","volume":"12","author":"Schehlein","year":"2017","journal-title":"Expert Rev. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/lsm.23783","article-title":"Evaluating the effect of pulse energy on femtosecond laser trabeculotomy (FLT) outflow channels for glaucoma treatment in human cadaver eyes","volume":"56","author":"Luo","year":"2024","journal-title":"Lasers Surg. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100313","DOI":"10.1016\/j.xops.2023.100313","article-title":"First-in-Human Safety Study of Femtosecond Laser Image-Guided Trabeculotomy for Glaucoma Treatment: 24-month Outcomes","volume":"3","author":"Nagy","year":"2023","journal-title":"Ophthalmol. Sci."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/10\/1591\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:05:39Z","timestamp":1760112339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/10\/1591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,28]]},"references-count":32,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["medicina60101591"],"URL":"https:\/\/doi.org\/10.3390\/medicina60101591","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2024,9,28]]}}}