{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:30:57Z","timestamp":1760146257582,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TU-DSPP-2024-81"],"award-info":[{"award-number":["TU-DSPP-2024-81"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Urine serves as a vital diagnostic fluid, and urine cytology analysis plays a crucial role in identifying urinary system illnesses such as bladder cancer and kidney stones. The Paris System for Reporting Urinary Cytology establishes a uniform method for diagnosing urinary tract cancer. This study aimed to provide valuable insights that can inform diagnostic strategies related to kidney stones and ultimately improve patient outcomes via the early detection of the cellular changes associated with kidney stones and their relation to kidney function tests. Materials and Methods: A comparative study was conducted and comprised two groups: group 1, consisting of 50 patients diagnosed with kidney stones, and group 2, comprising 50 patients diagnosed with other kidney diseases. Renal function tests and urinalysis (via the PAP staining of urine cellular deposits to detect nuclear changes) were performed, and the results were analyzed. Results: There was a statistically significant increase in urinary red blood cells, white blood cells, and nuclear reactive atypical changes in urinary sediments of kidney stone patients compared to the patients without stones, while there was a decrease in the estimated glomerular filtration rate (eGFR). eGFR showed a 96.7% specificity in detecting cases with nuclear reactive atypia. Conclusions: eGFR emerges as a reliable diagnostic marker for the comprehensive assessment of kidney stones, particularly when associated with nuclear atypia. The significant correlation between the indicators of chronic kidney disease, such as decreased eGFR, and the presence of kidney stones emphasizes the urgent need for efficient diagnostic practices.<\/jats:p>","DOI":"10.3390\/medicina60101630","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T06:23:18Z","timestamp":1728282198000},"page":"1630","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relation between Urine Cytological Findings and Renal Function in Patients with Kidney Stones in Taif, Saudi Arabia"],"prefix":"10.3390","volume":"60","author":[{"given":"Sahar Ali","family":"Qahtani","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences, Poison Control and Forensic Chemistry Center, Jeddah 21176, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadiga A.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howaida M.","family":"Hagag","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maram Jamel","family":"Hulbah","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha M.","family":"Bakhuraysah","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidaa Mahmoud","family":"Johari","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, Aljawdah Laboratory Company, Taif 72701, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman Mohammed","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, Ministry of Defense\u2014Saudi Armed Forces, Riyadh 11159, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seham","family":"Alajmani","sequence":"additional","affiliation":[{"name":"Department of Laboratory, King Faisal Medical Complex, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani Diafallah","family":"Alseyali","sequence":"additional","affiliation":[{"name":"Department of Laboratory, King Faisal Medical Complex, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal Ali","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Department of Laboratory, King Faisal Medical Complex, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid Abdullah","family":"Althagafi","sequence":"additional","affiliation":[{"name":"Department of Laboratory, King Faisal Medical Complex, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Awad","family":"Alnofaie","sequence":"additional","affiliation":[{"name":"Department of Laboratory, King Faisal Medical Complex, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulbadea Dawod","family":"Abdulaziz","sequence":"additional","affiliation":[{"name":"Department of Training and Learning, King Faisal Medical Complex, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulhadi","family":"Samman","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Pathology Division, College of Medicine, University of Jeddah, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussain","family":"Noorwali","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Pathology Division, College of Medicine, University of Jeddah, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed S.","family":"Abdelwahed","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Pathology Division, College of Medicine, University of Jeddah, Jeddah 21589, Saudi Arabia"},{"name":"Department of Pathology, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-306X","authenticated-orcid":false,"given":"Abdulkarim","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt"},{"name":"Department of Laboratory, Prince Mishari bin Saud Hospital, Al-Baha Health Cluster, A-Baha 65784, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3068365","DOI":"10.1155\/2018\/3068365","article-title":"Kidney Stone Disease: An Update on Current Concepts","volume":"2018","author":"Alelign","year":"2018","journal-title":"Adv. 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