{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:24:48Z","timestamp":1788222288892,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>A 79 year old female individual presented to the hospital and complained of 1 month melena and anemia due to chronic gastrointestinal bleeding because of cavernous hemangiomatosis of the small bowel. After undergoing an initial video laparoscopic jejunal\u2013ileal resection surgery 7 days after first hospitalization, given the persistence of anemia, she underwent laparotomic duodenojejunal resection surgery again 2 months later. Multiple cavernous hemangiomatosis is a rare vascular disease (7\u201310% of all benign small bowel tumors), and it often manifests with bleeding, which may be occult or massive; more rarely, it manifests with intestinal occlusion or perforation. Diagnoses often require the use of multiple radiological and endoscopic methods; video capsule endoscopy has significantly increased the diagnostic rate. The gold standard of treatment is surgical resection, whenever possible, balancing the need for radicality with the possible metabolic consequences of massive small intestine resections.<\/jats:p>","DOI":"10.3390\/medicina60101664","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T03:53:47Z","timestamp":1728618827000},"page":"1664","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiple Small Bowel Cavernous Hemangiomatosis: Case Report and Literature Review"],"prefix":"10.3390","volume":"60","author":[{"given":"Francesca","family":"R\u00e9","sequence":"first","affiliation":[{"name":"General Surgery Department, Villa Scassi, 16149 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6187-2775","authenticated-orcid":false,"given":"Salvatore","family":"Carrabetta","sequence":"additional","affiliation":[{"name":"General Surgery Department, Villa Scassi, 16149 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Merlo","sequence":"additional","affiliation":[{"name":"Pathology Department, Villa Scassi, 16149 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6680-4253","authenticated-orcid":false,"given":"Pietro","family":"Bisagni","sequence":"additional","affiliation":[{"name":"General Surgery Department, ASST Lodi\u2014Universit\u00e0 Statale di Milano, 20122 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"ref_1","first-page":"148","article-title":"Hemangioma of the small bowel. Case report","volume":"31","author":"Cardillo","year":"1989","journal-title":"Panminerva Medica"},{"key":"ref_2","first-page":"454836","article-title":"The \u201cEndothelialized Muscularis Mucosae\u201d: A Case Report Describing a Large Cavernous Hemangioma at the Terminal Ileum and a New Histologic Clue for Preoperative Diagnosis from Endoscopic Biopsy","volume":"2015","author":"Miner","year":"2015","journal-title":"Case Rep. Gastrointest. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1177\/000313480907500912","article-title":"Mesenteric cavernous hemangioma involving small bowel and appendix: A rare presentazione of a vascular tumor","volume":"75","author":"Parker","year":"2009","journal-title":"Am. Surg."},{"key":"ref_4","first-page":"bcr0820114672","article-title":"Bleeding small bowel cavernous hemangioma following blunt trauma to the abdomen presenting as subacute intestinal obstruction in a child","volume":"2011","author":"Khandasamy","year":"2011","journal-title":"BMJ Case"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"E249","DOI":"10.1055\/s-0041-111321","article-title":"Preoperative diagnosis of cavernous hemangioma presenting with melena using wireless capsule endoscopy of the small intestine","volume":"04","author":"Akazawa","year":"2016","journal-title":"Endosc. Int. Open"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/ajg.2015.246","article-title":"ACG Clinical Guideline: Diagnosis and Management of Small Bowel Bleeding","volume":"110","author":"Gerson","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_7","first-page":"259","article-title":"Cavernous Hemangioma (Cavernoma) of the ileum","volume":"41","author":"Cox","year":"1949","journal-title":"J. Natl. Med. Assoc."},{"key":"ref_8","first-page":"195","article-title":"Cavernous Hemangioma of the small intestine","volume":"10","author":"Grilli","year":"1989","journal-title":"Il G. Chirurgia."},{"key":"ref_9","first-page":"299","article-title":"Hemangioma as a cause of cryptogenic gastrointestinal hemorrhage","volume":"36","author":"Cacatian","year":"1969","journal-title":"J. Mt. Sinai Hospital."},{"key":"ref_10","first-page":"437","article-title":"Cavernous hemangioma of the small bowel: An uncommon cause of intestinal obstruction","volume":"26","author":"Calvo","year":"2003","journal-title":"An. Sist. Sanit. Navar."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jpedsurg.2005.06.014","article-title":"Solitary hemangioma of the small intestine: An inusual cause of bleeding diagnosed at capsule endoscopy","volume":"40","author":"Magnano","year":"2005","journal-title":"J. Pediatr. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gcb.2007.11.004","article-title":"Solitary hemangioma of the small bowel disclosed by wireless capsule endoscopy","volume":"32","author":"Pinho","year":"2008","journal-title":"Gastroent\u00e9rol. Clin. Et Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.aidm.2014.03.009","article-title":"Endoscopically diagnosed cavernous hemangioma in the deep small intestine: A case report","volume":"2","year":"2015","journal-title":"Adv. Dig. Med."},{"key":"ref_14","first-page":"139","article-title":"Imaging of a small bowel cavernous hemangioma: Report of a case with emphasis on the use of computed tomography and enteroclysis","volume":"78","author":"Corsi","year":"2007","journal-title":"Acta Bio. Medica"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4321\/S1130-01082012000500011","article-title":"Small bowel giant cavernous hemangioma diagnosed by capsule endoscopy","volume":"104","author":"Guardiola","year":"2012","journal-title":"Rev. Esp. Enfermedades Dig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.3748\/wjg.15.3319","article-title":"Large cavernous emangioma in the cecum treated by laparoscopic ileocecal resection","volume":"15","author":"Wook","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_17","first-page":"382","article-title":"Colorectal cavernous hemangiomatosis treated by total coloproctectomy and ileo-anal anastomosis","volume":"51","author":"Singland","year":"1997","journal-title":"Ann. Chir."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7371","DOI":"10.3748\/wjg.v12.i45.7371","article-title":"Diagnosis and treatment of small intestine bleeding: Retrospective analysis of 76 cases","volume":"12","author":"Ying","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/PAT.0000000000000050","article-title":"WHO classification of soft tissue tumours: An update based on the 2013 (4th) edition","volume":"46","author":"Jo","year":"2014","journal-title":"Pathology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.12788\/j.sder.2016.053","article-title":"Histopathology of vascular anomalies: Update based on the revised 2014 ISSVA classification","volume":"35","author":"Miller","year":"2016","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1016\/j.amjsurg.2009.11.015","article-title":"Combined capillary hemangioma and angiodysplasia of the ileum: An unusual cause of obscure gastrointestinal bleeding with preoperative localization by double-balloon endoscopy","volume":"200","author":"Lee","year":"2010","journal-title":"Am. J. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00003072-198801000-00009","article-title":"Detection of an ileal cavernous hemangioma by technetium-99m red blood cell imaging","volume":"13","author":"Holloway","year":"1988","journal-title":"Clin. Nucl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00004728-200007000-00027","article-title":"MR appearance of the small intestinal cavernous hemangioma","volume":"24","author":"Kazama","year":"2000","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.gie.2006.12.024","article-title":"Small bowel cavernous hemangioma: Wireless capsule endoscopy diagnosis of a surgical case","volume":"65","author":"Quentin","year":"2007","journal-title":"Gastrointest. Endosc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.gie.2007.07.044","article-title":"Multiple cavernous hemangiomas with iron deficiency anemia successfully treated with double-balloon enteroscopy","volume":"67","author":"Willert","year":"2008","journal-title":"Gastrointest. Endosc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.gie.2009.01.049","article-title":"Profound iron deficiency anemia caused by a small-intestinal cavernous hemangioma","volume":"69","author":"Chen","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"A18.e1","DOI":"10.1016\/j.cgh.2009.03.036","article-title":"Hemangioma of the small intestine presenting with recurrent overt, obscure gastrointestinal bleeding","volume":"8","author":"Elias","year":"2010","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_28","first-page":"343","article-title":"A rare cause of recurrent iron-deficiency anemia: Cavernous hemangioma of the small intestine","volume":"21","author":"Huber","year":"2012","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1007\/s11605-012-1991-6","article-title":"Solitary cavernous hemangioma of the small intestine as the cause of long-standing iron deficiency anemia","volume":"16","author":"Pera","year":"2012","journal-title":"J. Gastrointest. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ajg.2013.08.008","article-title":"Cavernous haemangioma of small intestine mimicking gastrointestinal stromal tumour","volume":"14","author":"Ersoy","year":"2013","journal-title":"Arab. J. Gastroenterol."},{"key":"ref_31","first-page":"214","article-title":"Cavernous hemangioma of small bowel: A rare cause of digestive hemorrhage","volume":"106","author":"Fernandes","year":"2014","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"340","DOI":"10.5946\/ce.2015.48.4.340","article-title":"Single cavernous hemangioma of the small bowel diagnosed by using capsule endoscopy in a child with chronic iron-deficiency anemia","volume":"48","author":"Bae","year":"2015","journal-title":"Clin. Endosc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1007\/s10620-016-4259-2","article-title":"A rare cause of recurrent gastrointestinal bleeding: Giant diffuse and cavernous intestinal mesentery hemangioma in an adult","volume":"61","author":"Peng","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"ref_34","first-page":"108","article-title":"Practical lessons from the small bowel bleeding lesions: A case report on small bowel cavernous hemangioma","volume":"42","author":"Ejtehadi","year":"2017","journal-title":"Iran. J. Med. Sci."},{"key":"ref_35","first-page":"e3113","article-title":"Cavernous Hemangioma of the Small Bowel: A Case Report and Literature Review","volume":"10","author":"Durer","year":"2018","journal-title":"Cureus"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"516","DOI":"10.4251\/wjgo.v10.i12.516","article-title":"Small intestinal hemangioma: Endoscopic or surgical intervention? A case report and review of literature","volume":"10","author":"Hu","year":"2018","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.3748\/wjg.v26.i14.1674","article-title":"Small bowel racemose hemangioma complicated with obstruction and chronic anemia: A case report and review of literature","volume":"26","author":"Fu","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_38","first-page":"e9296182","article-title":"Small intestinal hemangioma: Case report","volume":"22","author":"Beraldo","year":"2021","journal-title":"Am. J. Case"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1055\/a-2346-4938","article-title":"Endotherapy for small-bowel recurrent bleeding from a jejunal cavernous hemangioma in an elderly patient","volume":"56","author":"Gualandi","year":"2024","journal-title":"Endoscopy"},{"key":"ref_40","first-page":"342","article-title":"A case of solitary cavernous hemangioma of the small intestine with recurrent clinical anemic attacks in childhood","volume":"27","author":"Sakaguchi","year":"1998","journal-title":"J. Pediatr. Gastroenterol. Nutr."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/10\/1664\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:10:55Z","timestamp":1760112655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/10\/1664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["medicina60101664"],"URL":"https:\/\/doi.org\/10.3390\/medicina60101664","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]}}}