{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:01:57Z","timestamp":1793732517834,"version":"4.6.1"},"reference-count":60,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Subepithelial lesions (SELs) of the gastrointestinal (GI) tract present a diagnostic challenge due to their heterogeneous nature and varied clinical manifestations. Usually, SELs are small and asymptomatic; generally discovered during routine endoscopy or radiological examinations. Currently, endoscopic ultrasound (EUS) is the best tool to characterize gastric SELs. Materials and methods: For this review, the research and the study selection were conducted using the PubMed database. Articles in English language were reviewed from August 2019 to July 2024. Results: This review aims to summarize the international literature to examine and illustrate the progress in the last five years of endosonographic diagnostics and treatment of gastric SELs. Conclusions: Endoscopic ultrasound is the preferred option for the diagnosis of sub-epithelial lesions. In most of the cases, EUS-guided tissue sampling is mandatory; however, ancillary techniques (elastography, CEH-EUS, AI) may help in both diagnosis and prognostic assessment.<\/jats:p>","DOI":"10.3390\/medicina60101695","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T09:14:48Z","timestamp":1729242888000},"page":"1695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Endoscopic Ultrasound and Gastric Sub-Epithelial Lesions: Ultrasonographic Features, Tissue Acquisition Strategies, and Therapeutic Management"],"prefix":"10.3390","volume":"60","author":[{"given":"Marzia","family":"Varanese","sequence":"first","affiliation":[{"name":"Department of Surgery, Sapienza University of Rome, 00185 Rome, Italy"},{"name":"Division of Gastroenterology and Digestive Endoscopy, Humanitas Research Hospital\u2014IRCCS, Rozzano, 20089 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3909-9012","authenticated-orcid":false,"given":"Marco","family":"Spadaccini","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Digestive Endoscopy, Humanitas Research Hospital\u2014IRCCS, Rozzano, 20089 Milano, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-2156","authenticated-orcid":false,"given":"Antonio","family":"Facciorusso","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Medical Sciences, University of Foggia, 71100 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Franchellucci","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Digestive Endoscopy, Humanitas Research 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The results after routine endoscopy","volume":"5","author":"Hedenbro","year":"1991","journal-title":"Surg. Endosc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.14309\/ajg.0000000000002100","article-title":"ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions","volume":"118","author":"Jacobson","year":"2023","journal-title":"Am. J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.5946\/ce.2015.096","article-title":"Current guidelines in the management of upper gastrointestinal subepithelial tumors","volume":"49","author":"Cho","year":"2016","journal-title":"Clin. Endosc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1055\/s-2005-861422","article-title":"Endoscopic ultrasound and endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of malignant submucosal tumors","volume":"37","author":"Polkowski","year":"2005","journal-title":"Endoscopy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1055\/a-1751-5742","article-title":"Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"54","author":"Deprez","year":"2022","journal-title":"Endoscopy"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.gie.2017.02.022","article-title":"The role of endoscopy in subepithelial lesions of the GI tract","volume":"85","author":"Faulx","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zhong, Z., Xu, Y., Liu, J., Zhang, C., Xiao, Z., Xia, Y., Wang, Y., Wang, J., Xu, Q., and Lu, Y. (2022). Clinicopathological study of gastric schwannoma and review of related literature. BMC Surg., 22.","DOI":"10.1186\/s12893-022-01613-z"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00261-002-0055-x","article-title":"Endosonographic evaluation of ckit-positive gastrointestinal stromal tumor","volume":"28","author":"Okai","year":"2003","journal-title":"Abdom. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4253\/wjge.v15.i5.319","article-title":"Recent advances in endoscopic management of gastric neoplasms","volume":"15","author":"Cheema","year":"2023","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_10","unstructured":"National Comprehensive Cancer Network (2022, August 15). NCCN Clinical Practice Guidelines in Oncology: Gastrointestinal Stromal Tumors (GISTs). Available online: https:\/\/www.nccn.org\/."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4253\/wjge.v3.i5.86","article-title":"Endoscopic ultrasonography for gastric submucosal lesions","volume":"3","author":"Papanikolaou","year":"2011","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3748\/wjg.v28.i10.1009","article-title":"An update on the diagnosis of gastroenteropancreatic neuroendocrine neoplasms","volume":"28","author":"Fang","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00117-019-00593-1","article-title":"Neuroendocrine tumors of the stomach, duodenum and pancreas: Value of (hybrid) radiological diagnostics","volume":"59","author":"Auernhammer","year":"2019","journal-title":"Der Radiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1055\/s-0030-1255564","article-title":"Neuroendocrine tumors of the stomach (gastric carcinoids) are on the rise: Small tumors, small problems?","volume":"42","author":"Cadiot","year":"2010","journal-title":"Endoscopy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11605-018-3926-3","article-title":"Gastric Schwannoma","volume":"23","author":"Drago","year":"2019","journal-title":"J. Gastrointest. Surg."},{"key":"ref_16","unstructured":"Hawes, R.H., and Fockens, P. (2006). Submucosal lesions. Endosonography, Saunders Elsevier."},{"key":"ref_17","first-page":"586","article-title":"Adult gastric duplication cyst: Diagnosis by endoscopic ultrasound-guided fine-needle aspiration (EUSFNA)","volume":"100","year":"2008","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1055\/s-2008-1077400","article-title":"EUS for portal hypertension: A comprehensive and critical appraisal of clinical and experimental indications","volume":"40","author":"Jalil","year":"2008","journal-title":"Endoscopy"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.3748\/wjg.v13.i24.3301","article-title":"Diagnostic procedures for submucosal tumors in the gastrointestinal tract","volume":"13","author":"Ponsaing","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"E63","DOI":"10.1055\/s-0028-1119457","article-title":"Diagnosis by endoscopic ultrasound of a large aberrant pancreas mimicking malignant gastrointestinal stromal tumor of the stomach","volume":"41","author":"Akaraviputh","year":"2009","journal-title":"Endoscopy"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1007\/s00464-015-4729-1","article-title":"Feasibility of endoscopic submucosal dissection for upper gastrointestinal submucosal tumors treatment and value of endoscopic ultrasonography in pre-operation assess and postoperation follow-up: A prospective study of 224 cases in a single medical center","volume":"30","author":"He","year":"2016","journal-title":"Surg. Endosc."},{"key":"ref_22","first-page":"359","article-title":"A rare presentation of simple renal cyst: Gastrointestinal obstruction","volume":"11","author":"Sadeghi","year":"2018","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1080\/gas.37.7.856.862","article-title":"Accuracy of endoscopic ultrasonography in upper gastrointestinal submucosal lesions: A prospective multicenter study","volume":"37","author":"Kapfer","year":"2002","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Gheorghe, G., Bacalbasa, N., Ceobanu, G., Ilie, M., Enache, V., Constantinescu, G., Bungau, S., and Diaconu, C.C. (2021). Gastrointestinal Stromal Tumors. A Mini Review. J. Pers. Med., 11.","DOI":"10.3390\/jpm11080694"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/den.13367","article-title":"Mucosal incision-assisted biopsy versus endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions: A randomized cross-over study","volume":"31","author":"Osoegawa","year":"2019","journal-title":"Dig. Endosc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"615","DOI":"10.5946\/ce.2022.133","article-title":"Mucosal incision-assisted biopsy versus endoscopic ultrasound-assisted tissue acquisition for subepithelial lesions: A systematic review and meta-analysis","volume":"55","author":"Giri","year":"2022","journal-title":"Clin. Endosc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/a-2156-0063","article-title":"Comparative diagnostic yield of different endoscopic techniques for tissue sampling of upper gastrointestinal subepithelial lesions: A network meta-analysis","volume":"56","author":"Facciorusso","year":"2024","journal-title":"Endoscopy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1080\/00365521.2022.2144437","article-title":"The value of contrast-enhanced harmonic endoscopic ultrasound in differential diagnosis and evaluation of malignant risk of gastrointestinal stromal tumors (<50 mm)","volume":"58","author":"Wu","year":"2022","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/2303-9027.200216","article-title":"Contrast-enhanced(endoscopic) ultrasound and endoscopic ultrasound elastography in gastrointestinal stromal tumors","volume":"6","author":"Ignee","year":"2017","journal-title":"Endosc. Ultrasound."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"306","DOI":"10.5946\/ce.2019.056","article-title":"Contrast Enhanced Endoscopic Ultrasound Imaging for Gastrointestinal Subepithelial Tumors","volume":"52","author":"Tamura","year":"2019","journal-title":"Clin. Endosc."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Pallio, S., Crin\u00f2, S.F., Maida, M., Sinagra, E., Tripodi, V.F., Facciorusso, A., Ofosu, A., Conti Bellocchi, M.C., Shahini, E., and Melita, G. (2023). Endoscopic Ultrasound Advanced Techniques for Diagnosis of Gastrointestinal Stromal Tumours. Cancers, 15.","DOI":"10.3390\/cancers15041285"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"164","DOI":"10.5946\/ce.2023.074","article-title":"Role of contrast-enhanced harmonic endoscopic ultrasonography (EUS) and EUS elastography in pancreatic lesions","volume":"57","author":"Yamashita","year":"2024","journal-title":"Clin. Endosc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.gie.2017.12.031","article-title":"EUS elastography (strain ratio) and fractal-based quantitative analysis for the diagnosis of solid pancreatic lesions","volume":"87","author":"Carrara","year":"2018","journal-title":"Gastrointest. Endosc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s00535-020-01725-4","article-title":"Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors","volume":"55","author":"Minoda","year":"2020","journal-title":"J. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Minoda, Y., Ihara, E., Fujimori, N., Nagatomo, S., Esaki, M., Hata, Y., Bai, X., Tanaka, Y., Ogino, H., and Chinen, T. (2022). Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-20863-8"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00464-022-09597-w","article-title":"Artificial intelligence-assisted endoscopic ultrasound in the diagnosis of gastrointestinal stromal tumors: A meta-analysis","volume":"37","author":"Zhang","year":"2023","journal-title":"Surg. Endosc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.dld.2019.07.006","article-title":"Gastrointestinal stromal tumours (GISTs): French Intergroup Clinical Practice Guidelines for diagnosis, treatments and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO)","volume":"51","author":"Landi","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"ref_38","first-page":"378","article-title":"Management of gastrointestinal subepithelial lesions: An answer to the conflicting opinions","volume":"16","author":"Sadeghi","year":"2023","journal-title":"Gastroenterol. Hepatol. Bed Bench."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/1751-2980.12381","article-title":"EUS-guided FNA and FNB after on-site cytological evaluation in gastric subepithelial tumors","volume":"17","author":"Han","year":"2016","journal-title":"J. Dig. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/dc.24631","article-title":"Endoscopic ultrasound-guided fine needle aspiration cytology diagnosis of upper gastrointestinal tract mesenchymal tumors: Impact of rapid onsite evaluation and correlation with histopathologic follow-up","volume":"49","author":"Gilani","year":"2021","journal-title":"Diagn. Cytopathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1055\/a-1206-5552","article-title":"Comparison of fine-needle aspiration and fine-needle biopsy devices for endoscopic ultrasoundguided sampling of solid lesions: A systemic review and meta-analysis","volume":"53","author":"Erler","year":"2021","journal-title":"Endoscopy"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.gie.2024.02.003","article-title":"Diagnostic yield of endoscopic and EUS-guided biopsy techniques in subepithelial lesions of the upper GI tract: A systematic review","volume":"99","author":"Verloop","year":"2024","journal-title":"Gastrointest. Endosc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.gie.2022.11.022","article-title":"Auxiliary diagnosis of subephitelial lesions by impedance measurement during EUS-guided fine-neddle biopsy","volume":"97","author":"Minoda","year":"2023","journal-title":"Gastrointestinal Endosc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1055\/a-1915-5263","article-title":"Endoscopic ultrasound-guided fine-needle biopsy with or without macroscopic on-site evaluation: A randomized controlled noninferiority trial","volume":"55","author":"Mangiavillano","year":"2023","journal-title":"Endoscopy"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Sekine, M., Asano, T., and Mashima, H. (2022). The Diagnosis of Small Gastrointestinal Subepithelial Lesions by Endoscopic UltrasoundGuided Fine Needle Aspiration and Biopsy. Diagnostics, 12.","DOI":"10.3390\/diagnostics12040810"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1007\/s10620-011-1646-6","article-title":"Yield and performance characteristics of endoscopic ultrasound-guided fine needle aspiration for diagnosing upper GI tract stromal tumors","volume":"56","author":"Watson","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.gie.2017.01.010","article-title":"Comparison of FNA and fine-needle biopsy for EUS-guided sampling of suspected GI stromal tumors","volume":"86","author":"Loren","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/dc.23872","article-title":"Randomized crossover trial comparing EUS-guided fine-needle aspiration with EUS-guided fine-needle biopsy for gastric subepithelial tumors","volume":"46","author":"Iwai","year":"2018","journal-title":"Diagn. Cytopathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40477-020-00548-6","article-title":"Utility of endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) for diagnosing small subepithelial lesions (<20 mm)","volume":"25","author":"Sekine","year":"2022","journal-title":"J. Ultrasound."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10396-023-01342-7","article-title":"Endoscopic ultrasound-guided fne-needle aspiration for gastrointestinal subepithelial lesions","volume":"51","author":"Hikichi","year":"2024","journal-title":"J. Med. Ultrason."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"E266","DOI":"10.1055\/a-1075-1900","article-title":"EUS-guided 22-gauge fine needle biopsy versus single-incision with needle knife for the diagnosis of upper gastrointestinal subepithelial lesions: A randomized controlled trial","volume":"8","author":"Sanaei","year":"2020","journal-title":"Endosc. Int. Open"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5946\/ce.2019.019","article-title":"Comparison of the Diagnostic Ability of Endoscopic Ultrasonography and Abdominopelvic Computed Tomography in the Diagnosis of Gastric Subepithelial Tumors","volume":"52","author":"Kim","year":"2019","journal-title":"Clin. Endosc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s10120-018-00908-6","article-title":"Gastric sub-epithelial tumors: Identification of gastrointestinal stromal tumors using CT with a practical scoring method","volume":"22","author":"Liu","year":"2019","journal-title":"Gastric Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1007\/s00330-019-06534-9","article-title":"Multiparametric MRI and (18)F-FDG PET features for differentiating gastrointestinal stromal tumors from benign gastric subepithelial lesions","volume":"30","author":"Yoo","year":"2020","journal-title":"Eur. Radiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1055\/a-1172-6027","article-title":"Endoscopic ultrasound-guided tissue acquisition with or without macroscopic on-site evaluation: Randomized controlled trial","volume":"52","author":"Chong","year":"2020","journal-title":"Endoscopy"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000525993","article-title":"Endoscopic Submucosal Dissection for Subepithelial Tumor Treatment in the Upper Digestive Tract: A Western, Multicenter Study","volume":"30","author":"Manta","year":"2023","journal-title":"GE Port. J. Gastroenterol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s00464-017-5862-9","article-title":"Endoscopic resection of gastric gastrointestinal stromal tumors originating from the muscularis propria layer in North America: Methods and feasibility data","volume":"32","author":"Andalib","year":"2018","journal-title":"Surg. Endosc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e01214","DOI":"10.14309\/crj.0000000000001214","article-title":"Clip Dislodgement after Full-Thickness Endoscopic Resection Device Removal of Scarred Gastric Subepithelial Lesion Leading to Delayed Perforation","volume":"10","author":"Johnson","year":"2023","journal-title":"ACG Case Rep. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00464-016-4978-7","article-title":"Efficacy and safe of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors: A systematic review and meta-analysis","volume":"31","author":"Lv","year":"2017","journal-title":"Surg. Endosc."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Marano, L., Verre, L., Carbone, L., Poto, G.E., Fusario, D., Venezia, D.F., Calomino, N., Ka\u017amierczak-Siedlecka, K., Polom, K., and Marrelli, D. (2023). Current trends in volume and surgical outcomes in gastric cancer. J. Clin. Med., 12.","DOI":"10.3390\/jcm12072708"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/10\/1695\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:13:57Z","timestamp":1760112837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/10\/1695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,15]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["medicina60101695"],"URL":"https:\/\/doi.org\/10.3390\/medicina60101695","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,15]]}}}