{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:21:43Z","timestamp":1778170903612,"version":"3.51.4"},"reference-count":49,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>This case report describes an uncommon overlap syndrome between ankylosing spondylitis (AS) and amyotrophic lateral sclerosis (ALS). Initially, the patient was diagnosed with AS, for which he received various specific treatments, including TNF-\u03b1 inhibitors. After five years of treatment with TNF-\u03b1 inhibitor etanercept, the patient was referred for a full neurological assessment after he reported balance disturbances, postural instability, muscle weakness, and other neurological symptoms that indicated the presence of a neurological disorder. After a thorough investigation, the patient was diagnosed with ALS. This case report aims to contribute to the limited literature by providing a detailed case study regarding the crosstalk between AS and ALS while also exploring the potential underlying mechanisms and the possible link between TNF-\u03b1 inhibitors therapy and ALS.<\/jats:p>","DOI":"10.3390\/medicina60101703","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T04:42:15Z","timestamp":1729140135000},"page":"1703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Uncommon Overlap Syndrome Between Ankylosing Spondylitis and Amyotrophic Lateral Sclerosis\u2014Case Report"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5049-9861","authenticated-orcid":false,"given":"Christian","family":"Banciu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine IV, Faculty of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorin","family":"Chiriac","sequence":"additional","affiliation":[{"name":"Department of Surgery III, Faculty of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Pojoga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Regional Institute of Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania"},{"name":"Department Clinical Psychology and Psychotherapy, Babes-Bolyai University (UBB Med), 400015 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Marian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Timi\u015f County Emergency Clinical Hospital, 300723 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Fabian","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babe\u0219 Timi\u0219oara, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4301-2279","authenticated-orcid":false,"given":"Armand","family":"Gogulescu","sequence":"additional","affiliation":[{"name":"Department XVI: Balneology, Medical Rehabilitation and Rheumatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Simu","sequence":"additional","affiliation":[{"name":"Department of Neurology II, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"Parvanescu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical chemistry, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Mioc","sequence":"additional","affiliation":[{"name":"Department of Pharmacology\u2014Pharmacotherapy, Faculty of Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3378-0774","authenticated-orcid":false,"given":"Roxana","family":"Racoviceanu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical chemistry, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-5855","authenticated-orcid":false,"given":"Andreea","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Faculty of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41413-019-0057-8","article-title":"Ankylosing spondylitis: Etiology, pathogenesis, and treatments","volume":"7","author":"Zhu","year":"2019","journal-title":"Bone Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00296-009-0841-7","article-title":"Neurological complications of ankylosing spondylitis: Neurophysiological assessment","volume":"29","author":"Khedr","year":"2009","journal-title":"Rheumatol. 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