{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:41:39Z","timestamp":1784691699595,"version":"3.55.0"},"reference-count":70,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine, Pharmacy, Science, and Technology \u201cGeorge Emil Palade\u201d of Targu Mures","award":["511\/1\/17 January 2022"],"award-info":[{"award-number":["511\/1\/17 January 2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Cardiac transplantation represents the option for patients with end-stage heart failure (HF), providing the best survival rate. However, the postoperative complications of transplant patients remain a challenge for clinicians. The objective of our study was to evaluate the effect of preoperative chronic HF treatment on the occurrence of in-hospital complications. Materials and Methods: We retrospectively included a total of 50 patients who underwent cardiac transplantation between January 2011 and December 2023 from the Emergency Institute for Cardiovascular Diseases and Transplantation of Targu Mures. We correlated the preoperative chronic HF treatment with the postoperative complications by Spearmen\u2019s correlation coefficient, respectively. With logistic regression, the associations between the treatment and specific complications were determined. Results: Significant negative correlations were found between Carvedilol treatment with 2-month mortality (r = \u22120.30; 95% CI: \u22120.53\u2013\u22120.02; p = 0.03), Ramipril with hospital stay (r = \u22120.38; 95% CI: \u22120.60\u2013-0.12; p &lt; 0.01) and intensive care unit (ICU) stay (r = \u22120.37; 95% CI: \u22120.59\u2013\u22120.11; p = 0.01), and Spironolactone usage with hospitalization duration (r = \u22120.28; 95% CI: \u22120.52\u2013\u22120.01; p = 0.04). Furthermore, Carvedilol treatment represented a protective factor against early acute kidney injury (AKI) (OR: 0.22; 95% CI: 0.05\u20130.91; p = 0.03). Spironolactone treatment was a protective factor against AGR (OR: 0.12; 95% CI: 0.02\u20130.66; p = 0.01) treatment, in contrast to angiotensin-converting enzyme inhibitor (ACEI) therapy (OR: 5.30; 95% CI: 1.03\u201327.17; p = 0.04). Conclusions: Pre-transplant Carvedilol treatment was negatively correlated with the 2-month mortality rate. Ramipril and Spironolactone therapy were negatively correlated with hospitalization duration, and Ramipril was additionally correlated with ICU stay. Moreover, Carvedilol therapy represented a protective factor against early AKI. Pre-transplant Spironolactone was associated with lower event rates of AGR, in contrast to ACEI treatment. Prospective studies with larger cohorts are needed in order to draw drastic conclusions.<\/jats:p>","DOI":"10.3390\/medicina60111801","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T03:57:34Z","timestamp":1730692654000},"page":"1801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Heart Failure Chronic Treatment Prior to Cardiac Transplantation on Early Outcomes"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-9648","authenticated-orcid":false,"given":"Dragos-Florin","family":"Baba","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, George Emil Palade University of Medicine Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Emergency Institute for Cardiovascular Diseases and Transplant, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horatiu","family":"Suciu","sequence":"additional","affiliation":[{"name":"Emergency Institute for Cardiovascular Diseases and Transplant, 540136 Targu Mures, Romania"},{"name":"Department of Surgery, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-3329","authenticated-orcid":false,"given":"Calin","family":"Avram","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius Mihai","family":"Harpa","sequence":"additional","affiliation":[{"name":"Emergency Institute for Cardiovascular Diseases and Transplant, 540136 Targu Mures, Romania"},{"name":"Department of Surgery, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6297-0378","authenticated-orcid":false,"given":"Mircea","family":"Stoian","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Targu-Mures County Hospital, 540072 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5536-3938","authenticated-orcid":false,"given":"Diana-Andreea","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Emergency Institute for Cardiovascular Diseases and Transplant, 540136 Targu Mures, Romania"},{"name":"Department of Family Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9413-7803","authenticated-orcid":false,"given":"Laurentiu","family":"Huma","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, George Emil Palade University of Medicine Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Emergency Institute for Cardiovascular Diseases and Transplant, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Rusu","sequence":"additional","affiliation":[{"name":"Emergency Institute for Cardiovascular Diseases and Transplant, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunde","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V., George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Danilesco","sequence":"additional","affiliation":[{"name":"Targu-Mures County Hospital, 540072 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-4926","authenticated-orcid":false,"given":"Adina","family":"Stoian","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca-Ileana","family":"Sin","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, George Emil Palade University of Medicine Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.31083\/j.rcm2301011","article-title":"Current status and outcomes in heart transplantation: A narrative review","volume":"23","author":"Awad","year":"2022","journal-title":"Rev. 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