{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:01:40Z","timestamp":1790787700970,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Provincial Secretariat for Higher Education and Scientific Research, Autonomous Province of Vojvodina, Republic of Serbia","award":["142-451-3524\/2023"],"award-info":[{"award-number":["142-451-3524\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Obesity-related chronic inflammation may lead to neuroinflammation and neurodegeneration. This study aimed to evaluate the neurometabolic profile of obese patients using cerebral multivoxel magnetic resonance spectroscopy (mvMRS) and assess correlations between brain metabolites and obesity markers, including body mass index (BMI), waist circumference, waist-hip ratio, body fat percentage, and indicators of metabolic syndrome (e.g., triglycerides, HDL cholesterol, fasting blood glucose, insulin, and insulin resistance index (HOMA-IR)). Materials and Methods: This prospective study involved 100 participants, stratified into two groups: 50 obese individuals (BMI \u2265 30 kg\/m2) and 50 controls (18.5 \u2264 BMI &lt; 25 kg\/m2). Anthropometric measurements, body fat percentage, and biochemical markers were evaluated. All subjects underwent long- and short-echo mvMRS analysis of the frontal and parietal supracallosal subcortical and deep white matter, as well as the cingulate gyrus, analyzing NAA\/Cr, Cho\/Cr, and mI\/Cr ratios, along with absolute concentrations of NAA and Cho. Results: Obese participants exhibited significantly decreased NAA\/Cr and Cho\/Cr ratios in the deep white matter of the right cerebral hemisphere (p &lt; 0.001), while absolute concentrations of NAA and Cho did not differ significantly between groups (p &gt; 0.05). NAA levels showed negative correlations with more reliable obesity parameters (waist circumference and waist-to-hip ratio) but not with BMI, particularly in the deep frontal white matter and dorsal anterior cingulate gyrus of the left cerebral hemisphere. Notably, insulin demonstrated a significant negative impact on NAA (\u03c1 = \u22120.409 and \u03c1 = \u22120.410; p &lt; 0.01) and Cho levels (\u03c1 = \u22120.403 and \u03c1 = \u22120.392; p &lt; 0.01) at these locations in obese individuals. Conclusions: Central obesity and hyperinsulinemia negatively affect specific brain regions associated with cognitive and emotional processing, while BMI is not a reliable parameter for assessing brain metabolism.<\/jats:p>","DOI":"10.3390\/medicina60111880","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T05:36:45Z","timestamp":1731908205000},"page":"1880","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neurometabolic Profile in Obese Patients: A Cerebral Multi-Voxel Magnetic Resonance Spectroscopy Study"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-116X","authenticated-orcid":false,"given":"Milo\u0161","family":"Vukovi\u0107","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University in Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Nosek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University in Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Slotboom","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Neuroradiology, University Hospital Bern and Inselspital, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Medi\u0107 Stojanoska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University in Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-7072","authenticated-orcid":false,"given":"Du\u0161ko","family":"Kozi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University in Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/ana.21377","article-title":"Body mass index and magnetic resonance markers of brain integrity in adults","volume":"63","author":"Gazdzinski","year":"2008","journal-title":"Ann. 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