{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T15:36:45Z","timestamp":1776181005679,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: There is an increasing use of fecal matter transplantation (FMT) worldwide as research into the impact of the gut microbiome in various disease states is growing. FMT is the transfer of stool from a healthy human donor to a patient for the purpose of restoring intestinal dysbiosis. This review will assess the efficacy and safety of FMT in the treatment of pediatric inflammatory bowel diseases (IBDs) and explore the future directions of the use of FMT in children. Materials and Methods: A systematic review was performed where a literature search of publications published prior to 15 September 2023 was performed. Efficacy outcomes and safety data as well as microbiome analysis were reviewed from the studies where applicable. Results: Nine studies on UC and two studies on CD satisfied eligibility criteria and individually analysed. Most of the studies provided microbiome analyses. Conclusions: FMT is a safe treatment for paediatric IBD, and is shown to be effective in inducing clinical response by some studies. However the lack of randomized controlled trials limited the results of our study.<\/jats:p>","DOI":"10.3390\/medicina60111899","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T03:57:04Z","timestamp":1732075024000},"page":"1899","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Review of Fecal Microbiota Transplantation in Children\u2014Exploring Its Role in the Treatment of Inflammatory Bowel Diseases"],"prefix":"10.3390","volume":"60","author":[{"given":"Yanna","family":"Ko","sequence":"first","affiliation":[{"name":"School of Medicine, Western Sydney University, Campbelltown Campus, Sydney, NSW 2747, Australia"},{"name":"Canterbury Hospital, Sydney, NSW 2194, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Alaedin","sequence":"additional","affiliation":[{"name":"School of Medicine, Western Sydney University, Campbelltown Campus, Sydney, NSW 2747, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewni","family":"Fernando","sequence":"additional","affiliation":[{"name":"School of Medicine, Western Sydney University, Campbelltown Campus, Sydney, NSW 2747, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9741-0318","authenticated-orcid":false,"given":"Jerry","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Medicine, Western Sydney University, Campbelltown Campus, Sydney, NSW 2747, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3127-2933","authenticated-orcid":false,"given":"Vincent","family":"Ho","sequence":"additional","affiliation":[{"name":"School of Medicine, Western Sydney University, Campbelltown Campus, Sydney, NSW 2747, Australia"},{"name":"Camden and Campbelltown Hospitals, Sydney, NSW 2560, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3748\/wjg.v24.i1.5","article-title":"Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation","volume":"24","author":"Shen","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/apt.14201","article-title":"Systematic review with meta-analysis: The efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory Clostridium difficile infection","volume":"46","author":"Quraishi","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"829040","DOI":"10.1155\/2013\/829040","article-title":"Highlights in IBD Epidemiology and Its Natural History in the Paediatric Age","volume":"2013","author":"Gasparetto","year":"2013","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ibd.21048","article-title":"World Gastroenterology Organization Practice Guidelines for the diagnosis and management of IBD in 2010","volume":"16","author":"Bernstein","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.rdc.2013.03.010","article-title":"Update in pediatric inflammatory bowel disease","volume":"39","author":"Rabizadeh","year":"2013","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.7861\/clinmed.2021-0080","article-title":"Ulcerative colitis: An update","volume":"21","author":"Segal","year":"2021","journal-title":"Clin. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/MPG.0b013e31825959b8","article-title":"Health supervision in the management of children and adolescents with IBD: NASPGHAN recommendations","volume":"55","author":"Rufo","year":"2022","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6612970","DOI":"10.1155\/2021\/6612970","article-title":"Fecal Microbiota Transplantation as Therapy for Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis","volume":"2021","author":"Liu","year":"2021","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_9","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2013). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses, Ottawa Hospital Research Institute."},{"key":"ref_10","unstructured":"National Heart, Lung, and Blood Institute, National Institutes of Health, and U.S. Department of Health and Human Service (2023, August 20). Available online: https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Quagliariello, A., Del Chierico, F., Reddel, S., Russo, A., Onetti Muda, A., D\u2019Argenio, P., Angelino, G., Romeo, E.F., Dall\u2019Oglio, L., and De Angelis, P. (2020). Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations. Microorganisms, 8.","DOI":"10.3390\/microorganisms8101486"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Nusbaum, D.J., Sun, F., Ren, J., Zhu, Z., Ramsy, N., Pervolarakis, N., Kunde, S., England, W., Gao, B., and Fiehn, O. (2018). Gut microbial and metabolomic profiles after fecal microbiota transplantation in pediatric ulcerative colitis patients. FEMS Microbiol. Ecol., 94.","DOI":"10.1093\/femsec\/fiy133"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.5223\/pghn.2018.21.4.355","article-title":"Fecal Microbiota Transplantation to Patients with Refractory Very Early Onset Ulcerative Colitis","volume":"21","author":"Yodoshi","year":"2018","journal-title":"Pediatr. Gastroenterol. Hepatol. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/MPG.0b013e318292fa0d","article-title":"Safety, Tolerability, and Clinical Response After Fecal Transplantation in Children and Young Adults with Ulcerative Colitis","volume":"56","author":"Kunde","year":"2013","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5223\/pghn.2016.19.3.214","article-title":"Failure of Fecal Microbiota Transplantation in a Three-Year-Old Child with Severe Refractory Ulcerative Colitis","volume":"19","author":"Kumagai","year":"2016","journal-title":"Pediatr. Gastroenterol. Hepatol. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/ped.12967","article-title":"Repeated fecal microbiota transplantation in a child with ulcerative colitis","volume":"58","author":"Shimizu","year":"2016","journal-title":"Pediatr. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/MPG.0000000000000544","article-title":"Fecal Microbial Transplant Via Nasogastric Tube for Active Pediatric Ulcerative Colitis","volume":"60","author":"Suskind","year":"2015","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/ajg.2015.19","article-title":"Serial Fecal Microbiota Transplantation Alters Mucosal Gene Expression in Pediatric Ulcerative Colitis","volume":"110","author":"Kellermayer","year":"2015","journal-title":"Off. J. Am. Coll. Gastroenterol. ACG"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/MIB.0000000000000307","article-title":"Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn\u2019s disease","volume":"21","author":"Suskind","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/ibd\/izx035","article-title":"Safety, Clinical Response, and Microbiome Findings Following Fecal Microbiota Transplant in Children with Inflammatory Bowel Disease","volume":"24","author":"Goyal","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10620-020-06185-7","article-title":"Fecal Microbiota Transplantation (FMT) with Colonoscopy Is Superior to Enema and Nasogastric Tube While Comparable to Capsule for the Treatment of Recurrent Clostridium difficile Infection: A Systematic Review and Meta-Analysis","volume":"66","author":"Ramai","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/j.gastro.2015.04.001","article-title":"Fecal Microbiota Transplantation Induces Remission in Patients with Active Ulcerative Colitis in a Randomized Controlled Trial","volume":"149","author":"Moayyedi","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Hsu, M., Tun, K.M., Batra, K., Haque, L., Vongsavath, T., and Hong, A.S. (2023). Safety and Efficacy of Fecal Microbiota Transplantation in Treatment of Inflammatory Bowel Disease in the Pediatric Population: A Systematic Review and Meta-Analysis. Microorganisms, 11.","DOI":"10.3390\/microorganisms11051272"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Shi, Y., Dong, Y., Huang, W., Zhu, D., Mao, H., and Su, P. (2016). Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157259"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Zhang, B., Yang, L., Ning, H., Cao, M., Chen, Z., Chen, Q., Lian, G., Tang, H., Wang, Q., and Wang, J. (2023). A Matching Strategy To Guide Donor Selection for Ulcerative Colitis in Fecal Microbiota Transplantation: Meta-Analysis and Analytic Hierarchy Process. Microbiol. Spectr., 11.","DOI":"10.1128\/spectrum.02159-21"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/jama.2015.18098","article-title":"Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients with Recurrent Clostridium difficile Infection: A Randomized Clinical Trial","volume":"315","author":"Lee","year":"2016","journal-title":"JAMA"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/11\/1899\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:35:42Z","timestamp":1760114142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/11\/1899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":26,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["medicina60111899"],"URL":"https:\/\/doi.org\/10.3390\/medicina60111899","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]}}}