{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:09:59Z","timestamp":1773828599905,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n para la Investigaci\u00f3n y el Desarrollo de la Medicina Materno-Fetal y Neonatal, iMaterna","award":["2148"],"award-info":[{"award-number":["2148"]}]},{"name":"Fundaci\u00f3n para la Investigaci\u00f3n y el Desarrollo de la Medicina Materno-Fetal y Neonatal, iMaterna","award":["PID2022-137050NB-I00"],"award-info":[{"award-number":["PID2022-137050NB-I00"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n, Spain","award":["2148"],"award-info":[{"award-number":["2148"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n, Spain","award":["PID2022-137050NB-I00"],"award-info":[{"award-number":["PID2022-137050NB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: To evaluate the diagnostic accuracy of widely available biomarkers longitudinally measured throughout pregnancy to predict all and term (delivery at \u226537 weeks) preeclampsia (PE). Materials and Methods: This is a longitudinal retrospective study performed at Hospital Universitario de Torrej\u00f3n (Madrid, Spain) and Shterev Hospital (Sofia, Bulgaria) between August 2017 and December 2022. All pregnant women with singleton pregnancies and non-malformed live fetuses attending their routine ultrasound examination and first-trimester screening for preterm PE at 11 + 0 to 13 + 6 weeks\u2019 gestation at the participating centers were invited to participate in a larger study for the prediction of pregnancy complications. The dataset was divided into two subsets to develop and validate a joint model of time-to-event outcome and longitudinal data, and to evaluate how the area under the receiving operating characteristic curve (AUROC) evolved with time. Results: 4056 pregnancies were included in the training set (59 all PE, 40 term PE) and 944 in the validation set (23 all PE, 20 term PE). For the joint model and all PE, the AUROC was 0.84 (95% CI 0.73 to 0.94) and the detection rate (DR) for a 10% screening positive rate (SPR) was 56.5 (95% CI 34.5 to 76.8). For term PE, AUROC was 0.80 (95% CI 0.69 to 0.91), and DR for a 10% SPR was 55.0 (95% CI 31.5 to 76.9). The AUROC using only information from the first trimester was 0.50 (95% CI 0.37 to 0.64) and it increased to 0.84 (0.73 to 0.94) when using all information available. Conclusions: Routinely measuring MAP and UtA-PI throughout pregnancy may improve the predictive prediction power for all and term-PE.<\/jats:p>","DOI":"10.3390\/medicina60121909","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T04:46:11Z","timestamp":1732164371000},"page":"1909","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Continuous Risk Assessment of Late and Term Preeclampsia Throughout Pregnancy: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1793-7049","authenticated-orcid":false,"given":"Valeria","family":"Rolle","sequence":"first","affiliation":[{"name":"Faculty of Statistical Studies, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-2181","authenticated-orcid":false,"given":"Petya","family":"Chaveeva","sequence":"additional","affiliation":[{"name":"Dr. Shterev Hospital, 1330 Sofia, Bulgaria"},{"name":"Department of Obstetrics and Gynecology, Medical University of Pleven, 5800 Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6808-4800","authenticated-orcid":false,"given":"Ander","family":"Diaz-Navarro","sequence":"additional","affiliation":[{"name":"Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-5273","authenticated-orcid":false,"given":"Irene","family":"Fern\u00e1ndez-Buhigas","sequence":"additional","affiliation":[{"name":"Obstetrics Department, Torrej\u00f3n University Hospital, 28850 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Cuenca-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Obstetrics Department, Torrej\u00f3n University Hospital, 28850 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Tilkova","sequence":"additional","affiliation":[{"name":"Dr. Shterev Hospital, 1330 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Santacruz","sequence":"additional","affiliation":[{"name":"Obstetrics Department, Torrej\u00f3n University Hospital, 28850 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Faculty of Statistical Studies, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Institute of Statistics and Data Science, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9993-5249","authenticated-orcid":false,"given":"Maria M.","family":"Gil","sequence":"additional","affiliation":[{"name":"Obstetrics Department, Torrej\u00f3n University Hospital, 28850 Madrid, Spain"},{"name":"School of Medicine, Faculty of Health Sciences, Francisco de Vitoria University, 28223 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global Causes of Maternal Death: A WHO Systematic Analysis","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob. 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