{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T10:09:04Z","timestamp":1764842944357,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yeungnam University Research Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Postoperative recovery from general anesthesia is a multidimensional process, and patient-centered outcome assessment should be considered an important indicator of recovery quality. This study compared the effectiveness of intraoperative lidocaine and magnesium on postoperative recovery in nasal bone fracture surgery, using the quality of recovery-40 questionnaire (QoR-40) to assess recovery quality and pain intensity. Materials and Methods: A total of 74 patients scheduled for elective closed reduction surgery for isolated nasal bone fracture were assigned to the intraoperative infusions of lidocaine or magnesium. Immediately after anesthetic induction, 1.5 mg\/kg lidocaine or 20 mg\/kg magnesium was administered over 10 min, followed by a continuous infusion of 2 mg\/kg\/h lidocaine or 20 mg\/kg\/h magnesium until the end of the surgery. The primary outcome variable was the QoR-40 survey on postoperative day 1. The secondary outcome variables included postoperative pain intensity, sedation score, the incidence of postoperative nausea and vomiting, and other side effects. Results: The global QoR-40 score at postoperatively 24 h was comparable between the intraoperative lidocaine and magnesium groups. Postoperative pain 30 min after surgery was significantly lower in the lidocaine group than in the magnesium group (p = 0.01), along with lower rescue analgesic consumption (p = 0.003), but pain intensity was not different at other time points (2, 6, and 24 h). The incidence of nausea and vomiting and the sedation score in the post-anesthetic care unit were not significantly different between the two groups. Conclusions: Intraoperative lidocaine and magnesium had no difference in the scores of postoperative QoR-40, but lidocaine was associated with lower postoperative pain scores and analgesic requirement in comparison to magnesium in the closed reduction of nasal bone fractures.<\/jats:p>","DOI":"10.3390\/medicina60121939","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T06:25:19Z","timestamp":1732515919000},"page":"1939","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the Effects of Lidocaine Versus Magnesium Infusion on Quality of Recovery After Nasal Bone Fracture Surgery"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5758-6741","authenticated-orcid":false,"given":"Eun Kyung","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Yeungnam University College of Medicine, 170, Hyeonchung-ro, Nam-gu, Daegu 42415, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4007-770X","authenticated-orcid":false,"given":"Jongyoon","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Yeungnam University College of Medicine, 170, Hyeonchung-ro, Nam-gu, Daegu 42415, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6335-1818","authenticated-orcid":false,"given":"Kyu Jin","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, 170, Hyeonchung-ro, Nam-gu, Daegu 42415, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1399-6576.2009.02165.x","article-title":"Lidocaine vs. magnesium: Effect on analgesia after a laparoscopic cholecystectomy","volume":"54","author":"Saadawy","year":"2010","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.spinee.2013.09.031","article-title":"Intraoperative systemic infusion of lidocaine reduces postoperative pain after lumbar surgery: A double-blinded, randomized, placebo-controlled clinical trial","volume":"14","author":"Kim","year":"2014","journal-title":"Spine J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1213\/01.ANE.0000104582.71710.EE","article-title":"Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery","volume":"98","author":"Koppert","year":"2004","journal-title":"Anesth. Analg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/00000542-199602000-00011","article-title":"Role of magnesium sulfate in postoperative analgesia","volume":"84","author":"Tramer","year":"1996","journal-title":"Anesthesiology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1213\/ANE.0000000000002797","article-title":"Intravenously Administered Lidocaine and Magnesium During Thyroid Surgery in Female Patients for Better Quality of Recovery After Anesthesia","volume":"127","author":"Kim","year":"2018","journal-title":"Anesth. Analg."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kim, M.H., Lee, K.Y., Park, S., Kim, S.I., Park, H.S., and Yoo, Y.C. (2017). Effects of systemic lidocaine versus magnesium administration on postoperative functional recovery and chronic pain in patients undergoing breast cancer surgery: A prospective, randomized, double-blind, comparative clinical trial. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173026"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/oxfordjournals.bja.a013366","article-title":"Validity and reliability of a postoperative quality of recovery score: The QoR-40","volume":"84","author":"Myles","year":"2000","journal-title":"Br. J. Anaesth."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1213\/01.ane.0000265534.73169.95","article-title":"A systematic review of postoperative recovery outcomes measurements after ambulatory surgery","volume":"105","author":"Herrera","year":"2007","journal-title":"Anesth. Analg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40902-019-0236-y","article-title":"A retrospective clinical investigation for the effectiveness of closed reduction on nasal bone fracture","volume":"27","author":"Kang","year":"2019","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4097\/kjae.2012.63.1.48","article-title":"A comparative study of emergence agitation between sevoflurane and propofol anesthesia in adults after closed reduction of nasal bone fracture","volume":"63","author":"Kim","year":"2012","journal-title":"Korean J. Anesth."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/aas.12435","article-title":"Emergence agitation after orthognathic surgery: A randomised controlled comparison between sevoflurane and desflurane","volume":"59","author":"Choi","year":"2015","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"102044","DOI":"10.1016\/j.jormas.2024.102044","article-title":"Airway management in patients undergoing maxillofacial surgery: State of art review","volume":"5","author":"Merola","year":"2024","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/bja\/aet014","article-title":"Measurement of quality of recovery using the QoR-40: A quantitative systematic review","volume":"111","author":"Gornall","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/EJA.0b013e32832a0c7c","article-title":"Effects of clonidine and midazolam premedication on bispectral index and recovery after elective surgery","volume":"26","author":"Paris","year":"2009","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e33071","DOI":"10.1097\/MD.0000000000033071","article-title":"Effect on music therapy on quality of recovery and postoperative pain after gynecological laparoscopy","volume":"102","author":"Choi","year":"2023","journal-title":"Medicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12630-010-9407-0","article-title":"Perioperative intravenous lidocaine infusion for postoperative pain control: A meta-analysis of randomized controlled trials","volume":"58","author":"Vigneault","year":"2011","journal-title":"Can. J. Anaesth."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/EJA.0000000000001348","article-title":"Intravenously injected lidocaine or magnesium improves the quality of early recovery after laparoscopic cholecystectomy: A randomised controlled trial","volume":"38","author":"Lu","year":"2021","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/bja\/aep334","article-title":"infusion of magnesium sulphate during spinal anaesthesia improves postoperative analgesia","volume":"104","author":"Hwang","year":"2010","journal-title":"Br. J. Anaesth."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.bpa.2017.07.001","article-title":"Stable anesthesia with alternative to opioids: Are ketamine and magnesium helpful in stabilizing hemodynamics during surgery? A systematic review and meta-analyses of randomized controlled trials","volume":"31","author":"Forget","year":"2017","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4097\/kjae.2011.60.5.329","article-title":"Evaluation of dose effects of magnesium sulfate on rocuronium injection pain and hemodynamic changes by laryngoscopy and endotracheal intubation","volume":"60","author":"Shin","year":"2011","journal-title":"Korean J. Anesth."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1365-2044.2003.03082_1.x","article-title":"A survey of peri-operative use of magnesium sulphate in adult cardiac surgery in the UK","volume":"58","author":"Roscoe","year":"2003","journal-title":"Anaesthesia"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4097\/kjae.2013.65.1.4","article-title":"Magnesium: A versatile drug for anesthesiologist","volume":"65","author":"Do","year":"2013","journal-title":"Korean J. Anesth."},{"key":"ref_23","first-page":"10732","article-title":"Comparison of intravenous injection of magnesium sulfate and lidocaine effectiveness on the prevention of laryngospasm and analgesic requirement in tonsillectomy","volume":"32","author":"Manouchehrian","year":"2022","journal-title":"Eur. J. Transl. Myol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/12\/1939\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:38:57Z","timestamp":1760114337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/12\/1939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":23,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["medicina60121939"],"URL":"https:\/\/doi.org\/10.3390\/medicina60121939","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2024,11,25]]}}}