{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:38:14Z","timestamp":1760146694580,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>A disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7) belongs to the family of metalloproteinases that contributes to tissue homeostasis during morphogenesis and reproduction. These metalloproteinases regulate various cell functions such as cell proliferation, are important regulators in tissue regeneration, and play a role in vascular remodelling, which is involved in atherosclerosis development. Despite the well-established association between ADAMTS-7 and atherosclerotic disease, data regarding the metalloproteinase\u2019s association with LV function remain scarce. The aim of this study was to investigate the association of ADAMTS-7 levels with diastolic dysfunction and various echocardiographic parameters in patients with type 2 diabetes mellitus. All patients underwent a clinical, vascular, and echocardiographic examination during their visit. Plasma ADAMTS-7 levels were measured in all patients. The results showed that diastolic dysfunction was strongly associated with age, but had no statistically significant association with ADAMTS-7. When individual echocardiographic parameters were examined, ADAMTS-7 levels showed a positive tendency only with deceleration time (DT), with the other echocardiographic parameters being positively associated only with age. The possible role of ADAMTS-7 in diastolic dysfunction and in the development and progression of heart failure in patients with type 2 diabetes mellitus deserves further investigation.<\/jats:p>","DOI":"10.3390\/medicina60121981","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T06:58:58Z","timestamp":1733122738000},"page":"1981","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus"],"prefix":"10.3390","volume":"60","author":[{"given":"Asimina","family":"Ganotopoulou","sequence":"first","affiliation":[{"name":"Research Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"},{"name":"Department of Internal Medicine and Diabetes Centre, Tzaneio General Hospital of Piraeus, 185 36 Piraeus, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-5488","authenticated-orcid":false,"given":"Emmanouil","family":"Korakas","sequence":"additional","affiliation":[{"name":"Research Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loukia","family":"Pliouta","sequence":"additional","affiliation":[{"name":"Research Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5829-7327","authenticated-orcid":false,"given":"Aikaterini","family":"Kountouri","sequence":"additional","affiliation":[{"name":"Research Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6480-3878","authenticated-orcid":false,"given":"Sotirios","family":"Pililis","sequence":"additional","affiliation":[{"name":"Research Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6481-0000","authenticated-orcid":false,"given":"Stamatios","family":"Lampsas","sequence":"additional","affiliation":[{"name":"2nd Department of Ophthalmology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-7886","authenticated-orcid":false,"given":"Ignatios","family":"Ikonomidis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7349-0309","authenticated-orcid":false,"given":"Loukianos S.","family":"Rallidis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasia","family":"Papazafiropoulou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Diabetes Centre, Tzaneio General Hospital of Piraeus, 185 36 Piraeus, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Melidonis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Diabetes Centre, Tzaneio General Hospital of Piraeus, 185 36 Piraeus, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaia","family":"Lambadiari","sequence":"additional","affiliation":[{"name":"Research Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/cvr\/cvad026","article-title":"Global burden of heart failure: A comprehensive and updated review of epidemiology","volume":"119","author":"Savarese","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Grigorescu, E.D., Lacatusu, C.M., Floria, M., Mihai, B.M., Cretu, I., and Sorodoc, L. (2019). Left Ventricular Diastolic Dysfunction in Type 2 Diabetes-Progress and Perspectives. Diagnostics, 9.","DOI":"10.3390\/diagnostics9030121"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrcardio.2014.83","article-title":"The pathophysiology of heart failure with preserved ejection fraction","volume":"11","author":"Borlaug","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jcmg.2012.03.015","article-title":"Acute left ventricular remodeling following myocardial infarction: Coupling of regional healing with remote extracellular matrix expansion","volume":"5","author":"Chan","year":"2012","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.biocel.2004.01.014","article-title":"A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: The ADAMTS family","volume":"36","author":"Apte","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Hanby, H.A., and Zheng, X.L. (2013). Biochemistry and physiological functions of ADAMTS7 metalloprotease. Adv. Biochem., 1.","DOI":"10.11648\/j.ab.20130103.11"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ng.784","article-title":"Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease","volume":"43","author":"Schunkert","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0140-6736(10)61996-4","article-title":"Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: Two genome-wide association studies","volume":"377","author":"Reilly","year":"2011","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/CIRCRESAHA.108.188425","article-title":"ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries","volume":"104","author":"Wang","year":"2009","journal-title":"Circ. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40001-015-0118-4","article-title":"Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction","volume":"20","author":"Wu","year":"2015","journal-title":"Eur. J. Med. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40001-018-0305-1","article-title":"Association of serum ADAMTS-7 levels with left ventricular reverse remodeling after ST-elevation myocardial infarction","volume":"23","author":"Wu","year":"2018","journal-title":"Eur. J. Med. Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Panesar, D.K., and Burch, M. (2017). Assessment of Diastolic Function in Congenital Heart Disease. Front. Cardiovasc. Med., 4.","DOI":"10.3389\/fcvm.2017.00005"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/CIRCULATIONAHA.114.012669","article-title":"Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice","volume":"131","author":"Bauer","year":"2015","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e5523","DOI":"10.1097\/MD.0000000000005523","article-title":"Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease","volume":"95","author":"Yu","year":"2016","journal-title":"Medicine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCRESAHA.123.322737","article-title":"ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1","volume":"133","author":"Sharifi","year":"2023","journal-title":"Circ. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Bengtsson, E., Hultman, K., Dun\u00e9r, P., Asciutto, G., Almgren, P., Orho-Melander, M., Melander, O., Nilsson, J., Hultg\u00e5rdh-Nilsson, A., and Gon\u00e7alves, I. (2017). ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-03573-4"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20915","DOI":"10.18632\/aging.104118","article-title":"Association of polymorphisms in ADAMTS-7 gene with the susceptibility to coronary artery disease\u2014A systematic review and meta-analysis","volume":"12","author":"Hosseini","year":"2020","journal-title":"Aging"},{"key":"ref_18","first-page":"9032378","article-title":"SGLT2i and GLP-1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence","volume":"2021","author":"Morillo","year":"2021","journal-title":"J. Diabetes Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/physrev.1999.79.1.215","article-title":"Molecular mechanisms of myocardial remodeling","volume":"79","author":"Swynghedauw","year":"1999","journal-title":"Physiol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/01.RES.0000013290.12884.A3","article-title":"Matrix metalloproteinases: Regulation and dysregulation in the failing heart","volume":"90","author":"Spinale","year":"2002","journal-title":"Circ. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00395-013-0374-9","article-title":"Deficiency of cartilage oligomeric matrix protein causes dilated cardiomyopathy","volume":"108","author":"Huang","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"ref_22","first-page":"706","article-title":"COMP-assisted collagen secretion\u2014A novel intracellular function required for fibrosis","volume":"129","author":"Schulz","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.lfs.2015.12.034","article-title":"Olmesartan ameliorates pressure overload-induced cardiac remodeling through inhibition of TAK1\/p38 signaling in mice","volume":"145","author":"Wu","year":"2016","journal-title":"Life Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e001359","DOI":"10.1161\/JAHA.114.001359","article-title":"Predictive utility of the changes in matrix metalloproteinase-2 in the early phase for left ventricular reverse remodeling after an acute myocardial infarction","volume":"4","author":"Morishita","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ajhg.2013.01.012","article-title":"ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant","volume":"92","author":"Pu","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2217\/bmm-2020-0161","article-title":"Investigating ADAMTS7 and ADAMTS12 levels in prediabetic and Type 2 diabetic patients","volume":"15","author":"Beysel","year":"2021","journal-title":"Biomark. Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/12\/1981\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:44:33Z","timestamp":1760114673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/12\/1981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,2]]},"references-count":26,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["medicina60121981"],"URL":"https:\/\/doi.org\/10.3390\/medicina60121981","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2024,12,2]]}}}