{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T18:49:00Z","timestamp":1787338140251,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Ischemia-reperfusion (I\/R) injury is a process in which impaired perfusion is restored by restoring blood flow and tissue recirculation. Nanomedicine uses cutting-edge technologies that emerge from interdisciplinary influences. In the literature, there are very few in vivo and in vitro studies on how cerium oxide (CeO2) affects systemic anti-inflammatory response and inflammation. Therefore, in our study, we aimed to investigate whether CeO2 administration has a protective effect against myocardial I\/R injury in the liver and kidneys. Materials and Methods: Twenty-four rats were randomly divided into four groups after obtaining approval from an ethics committee. A control (group C), cerium oxide (group CO), IR (group IR), and Cerium oxide-IR (CO-IR group) groups were formed. Intraperitoneal CeO2 was administered at a dose of 0.5 mg\/kg 30 min before left thoracotomy and left main coronary (LAD) ligation, and myocardial muscle ischemia was induced for 30 min. After LAD ligation was removed, reperfusion was performed for 120 min. All rats were euthanized using ketamine, and blood was collected. Liver and kidney tissue samples were evaluated histopathologically. Serum AST (aspartate aminotransferase), ALT (alanine aminotransaminase), GGT (gamma-glutamyl transferase), glucose, TOS (Total Oxidant Status), and TAS (Total Antioxidant Status) levels were also measured. Results: Necrotic cell and mononuclear cell infiltration in the liver parenchyma of rats in the IR group was observed to be significantly increased compared to the other groups. Hepatocyte degeneration was greater in the IR group compared to groups C and CO. Vascular vacuolization and hypertrophy, tubular degeneration, and necrosis were increased in the kidney tissue of the IR group compared to the other groups. Tubular dilatation was significantly higher in the IR group than in the C and CO groups. TOS was significantly higher in all groups than in the IR group (p &lt; 0.0001, p &lt; 0.0001, and p = 0.006, respectively). However, TAS level was lower in the IR group than in the other groups (p = 0.002, p = 0.020, and p = 0.031, respectively). Renal and liver histopathological findings decreased significantly in the CO-IR group compared to the IR group. A decrease in the TOS level and an increase in the TAS level were found compared to the IR group. The AST, ALT, GGT, and Glucose levels are shown. Conclusions: CeO2 administered before ischemia-reperfusion reduced oxidative stress and ameliorated IR-induced damage in distant organs. We suggest that CeO2 exerts protective effects in the myocardial IR model.<\/jats:p>","DOI":"10.3390\/medicina60122044","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T12:58:49Z","timestamp":1733921929000},"page":"2044","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Cerium Oxide on Kidney and Liver Tissue Damage in an Experimental Myocardial Ischemia-Reperfusion Model of Distant Organ Damage"],"prefix":"10.3390","volume":"60","author":[{"given":"I\u015f\u0131n","family":"G\u00fcne\u015f","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Erciyes University Faculty of Medicine, Kayseri 38039, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9056-0025","authenticated-orcid":false,"given":"Ali Do\u011fan","family":"Dursun","sequence":"additional","affiliation":[{"name":"Department of Physiology, At\u0131l\u0131m University Faculty of Medicine, Ankara 06560, Turkey"},{"name":"Vocational School of Health Services, Atilim University, Cankaya, Ankara 06805, Turkey"},{"name":"Home Care Services, Medicana International Ankara Hospital, Cankaya, Ankara 06520, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-8054","authenticated-orcid":false,"given":"\u00c7a\u011fr\u0131","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara 06560, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015feg\u00fcl","family":"K\u00fc\u00e7\u00fck","sequence":"additional","affiliation":[{"name":"Department of Physiology, Kutahya Health Sciences University Faculty of Medicine, Kutahya 43100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eaban Cem","family":"Sezen","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, K\u0131r\u0131kkale University Faculty of Medicine, K\u0131r\u0131kkale 71000, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4882-5063","authenticated-orcid":false,"given":"Mustafa","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara 06560, Turkey"},{"name":"Application and Research Centre for Life Sciences, Gazi University, Ankara 06560, Turkey"},{"name":"Centre for Laboratory Animal Breeding and Experimental Research (G\u00dcDAM), Gazi University, Ankara 06560, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Department Cardiovascular Surgery, Gazi University Faculty of Medicine, Ankara 06560, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s12576-014-0333-8","article-title":"Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: Activation of nitric oxide system and mitochondrial K ATP channel","volume":"64","author":"Badalzadeh","year":"2014","journal-title":"J. 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