{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:40:57Z","timestamp":1760118057798,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background\/Objective: Surgical treatment of extensive tumors of the lower lip generates important defects in its structure and functions. Over time, a multitude of reconstruction options for these defects have been imagined. Unfortunately, the majority involve the use of both local and regional flaps, which either lack labial structure or disorganize the oral commissures as nodal oral function points. We set out to design a new reconstruction method that is not burdened by any of the above disadvantages, starting from the necessity to reconstruct large lower lip defects by exclusively using local and\/or regional labial flaps belonging only to the healthy upper lip and the remaining structures of the lower lip after surgical tumor removal. In this way, the tissues involved in lower lip reconstruction will have a 100% labial structure and, supplementarily, the remaining oral commissures will not be damaged. Method: This new reconstruction method is based on the original association of WY-plasty to reduce the size of the large primary defect until it becomes congruent with the Abbe\u2013Sabattini cross-lip flap. Results: Applied in a personalized manner, impressive results were obtained in several patients with lip tumors affecting about one-half of the lower lip length and in whom oncological surgical ablation produced defects in more than two-thirds of it. Conclusions: This new method is characterized by functional oral advantages, and can be applied in a personalized way to only certain categories of patients. Other disadvantages are characteristic and specific of Abbe\u2013Sabattini cross-lip flap plasty.<\/jats:p>","DOI":"10.3390\/medicina61010004","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T09:00:57Z","timestamp":1735030857000},"page":"4","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Original Personalized Reconstruction Method for Certain Large Tumors of the Lower Lip (Not Including Oral Commissures)"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3518-3914","authenticated-orcid":false,"given":"Ovidiu Dan","family":"Grigorescu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Transilvania University of Bra\u0219ov, 29, B-dul Eroilor, 5000036 Bra\u0219ov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Irimie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Transilvania University of Bra\u0219ov, 29, B-dul Eroilor, 5000036 Bra\u0219ov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4263-2589","authenticated-orcid":false,"given":"Nadinne","family":"Roman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Transilvania University of Bra\u0219ov, 29, B-dul Eroilor, 5000036 Bra\u0219ov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana Steliana","family":"Miclaus","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Transilvania University of Bra\u0219ov, 29, B-dul Eroilor, 5000036 Bra\u0219ov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Cristina","family":"C\u00eempeanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Transilvania University of Bra\u0219ov, 29, B-dul Eroilor, 5000036 Bra\u0219ov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9277-9207","authenticated-orcid":false,"given":"Bogdan-Radu","family":"Necula","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Transilvania University of Bra\u0219ov, 29, B-dul Eroilor, 5000036 Bra\u0219ov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6786-8237","authenticated-orcid":false,"given":"Christian-Gabriel","family":"Strempel","sequence":"additional","affiliation":[{"name":"Faculty of Economic Sciences and Business Administration, Transilvania University of Bra\u0219ov, 29, B-dul Eroilor, 5000036 Bra\u0219ov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Grigorescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Transilvania University of Bra\u0219ov, 29, B-dul Eroilor, 5000036 Bra\u0219ov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2442-6917","authenticated-orcid":false,"given":"Marius Alexandru","family":"Moga","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Transilvania University of Bra\u0219ov, 29, B-dul Eroilor, 5000036 Bra\u0219ov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3377-593X","authenticated-orcid":false,"given":"Dana Gabriela","family":"Festila","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 8, Victor Babes Str., 400347 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jobcr.2020.09.007","article-title":"Reconstruction of acquired lip defects: Ten-year experience at a tertiary care center","volume":"10","author":"Dadhich","year":"2020","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/01.moo.0000130574.03032.e2","article-title":"Current concepts in lip reconstruction","volume":"12","author":"Coppit","year":"2004","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_3","first-page":"Doc02","article-title":"Functional and aesthetic outcome of different methods of reconstruction of full thickness lip defects","volume":"11","author":"Shaikh","year":"2022","journal-title":"GMS Interdiscip. Plast. Reconstr. Surg. DGPW"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0030-6665(05)70010-4","article-title":"Lip and perioral defects","volume":"34","author":"Galyon","year":"2001","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Butler, C.E., and Fine, N.A. (2008). Lip, Cheek, and Scalp Reconstruction. Principles of Cancer Reconstructive Surgery, Springer.","DOI":"10.1007\/978-0-387-49504-0"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0030-6665(20)31221-4","article-title":"Reconstruction of the lip","volume":"23","author":"Renner","year":"1990","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/MOO.0b013e3283557dcf","article-title":"Local flap reconstruction of acquired lip defects","volume":"20","author":"Harris","year":"2012","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_8","unstructured":"Converse, J.M., McCarthy, J.G., and Littler, J.W. (1977). Reconstructive Plastic Surgery: Principles and Procedures in Correction, Reconstruction, and Transplantation, W. B. Saunders. Available online: https:\/\/cir.nii.ac.jp\/crid\/1130000795055782912."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1054\/ijom.2002.0232","article-title":"Surgical margins for resection of squamous cell carcinoma of the lower lip","volume":"31","author":"Gooris","year":"2002","journal-title":"Int. J. Oral. Maxillofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1089\/fpsam.2020.0068","article-title":"Myomucosal Lip Island Flap for Reconstruction of Small to Medium Lower Lip Defects","volume":"22","author":"Madorsky","year":"2020","journal-title":"Facial Plast. Surg. Aesthetic Med."},{"key":"ref_11","unstructured":"Zide, M. (1990). Deformities of the lips and cheeks. Plastic Surgery, W.B. Saunders."},{"key":"ref_12","first-page":"ic30","article-title":"The Abbe Flap for Upper Lip Reconstruction","volume":"14","author":"Nyame","year":"2014","journal-title":"Eplasty"},{"key":"ref_13","first-page":"ic17","article-title":"Lower Lip Reconstruction: Karapandzic Flap","volume":"13","author":"Sood","year":"2013","journal-title":"Eplasty"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.joms.2005.12.031","article-title":"Upper Lip Reconstruction with the Alar Crescent Flap: A New Approach","volume":"64","author":"Spinelli","year":"2006","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1097\/00042728-200511000-00014","article-title":"Perialar Crescentic Advancement Flap for Upper Cutaneous Lip Defects","volume":"31","author":"Wang","year":"2005","journal-title":"Dermatol. Surg."},{"key":"ref_16","first-page":"19","article-title":"Near-total lower lip reconstruction: Combined Karapandzic and Bernard-Burrow-Webster flap","volume":"26","author":"Campos","year":"2017","journal-title":"Acta Dermatovenerol Alp. Pannon. Adriat."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00006534-199108000-00005","article-title":"Reconstruction of the Lower Lip and Chin with the Composite Radial Forearm\u2014Palmaris Longus Free Flap","volume":"88","author":"Sadove","year":"1991","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1177\/000348941212100906","article-title":"Free-flap reconstruction of large full-thickness lip and chin defects","volume":"121","author":"Godefroy","year":"2012","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/00001665-200305000-00020","article-title":"Total lower lip reconstruction using sensate composite radial forearm flap","volume":"14","author":"Ortak","year":"2003","journal-title":"J. Craniofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1001\/archfaci.5.2.197","article-title":"The cervicodeltopectoral flap for single-stage resurfacing of anterolateral defects of the face and neck","volume":"5","author":"Ducic","year":"2003","journal-title":"Arch. Facial Plast. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.31925\/farmacia.2023.3.13","article-title":"Antimicrobial Resistance of Eskape Pathogens in Major Burns Patients-One-Year Retrospective Study","volume":"71","author":"Hodea","year":"2023","journal-title":"Farmacia"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zhang, J., Yang, Q., Wu, J., Yuan, R., Zhao, X., Li, Y., Cheng, X., Wu, B., and Zhu, N. (2023). Trends in cutaneous squamous cell carcinoma on the lip incidence and mortality in the United States, 2000\u20132019. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1111907"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1001\/jamaoto.2016.3455","article-title":"Epidemiology of Squamous Cell Carcinoma of the Lip in the United States: A Population-Based Cohort Analysis","volume":"142","author":"Han","year":"2016","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdcr.2023.05.021","article-title":"Large squamous cell carcinoma of the lip in a Black woman with a history of hydrochlorothiazide use treated with Mohs micrographic surgery","volume":"38","author":"Miller","year":"2023","journal-title":"JAAD Case Rep."},{"key":"ref_25","first-page":"5519","article-title":"Effect of comprehensive nursing on the appearance and recovery effect of oral squamous cell carcinoma patients","volume":"13","author":"Lu","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_26","first-page":"e50954","article-title":"Importance of Cardiac Rehabilitation and Mouth Opening Exercises in Oral Squamous Cell Carcinoma: A Case Report","volume":"15","author":"Bhoyar","year":"2023","journal-title":"Cureus"},{"key":"ref_27","first-page":"e31293","article-title":"Physiotherapy for Trismus Using Rocabado Exercises Following Mandibulectomy for Squamous Cell Carcinoma of the Lower Lip: A Case Report","volume":"14","author":"Mangulkar","year":"2022","journal-title":"Cureus"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13039-016-0293-1","article-title":"EEarly detection and personalized treatment in oral cancer: The impact of omics approaches","volume":"9","author":"Ribeiro","year":"2016","journal-title":"Mol. Cytogenet."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Menditti, D., Santagata, M., Imola, G., Staglian\u00f2, S., Vitagliano, R., Boschetti, C.E., and Inchingolo, A.M. (2023). Personalized Medicine in Oral Oncology: Imaging Methods and Biological Markers to Support Diagnosis of Oral Squamous Cell Carcinoma (OSCC): A Narrative Literature Review. J. Pers. Med., 13.","DOI":"10.3390\/jpm13091397"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/1\/4\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:59:22Z","timestamp":1760115562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/1\/4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["medicina61010004"],"URL":"https:\/\/doi.org\/10.3390\/medicina61010004","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2024,12,24]]}}}