{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:42:25Z","timestamp":1760146945307,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Video-assisted thoracoscopic surgery (VATS) is associated with less postoperative pain than traditional open thoracotomy. However, trocar and chest tube placement may damage the intercostal nerves, causing significant discomfort. An ultrasound-guided serratus anterior plane block (SAPB) is a promising mode of pain management; this reduces the need for opioids and the associated side-effects. This study evaluated whether SAPB, compared to intravenous analgesia alone, reduces opioid consumption after thoracoscopic lung wedge resection. Materials and Methods: In total, 22 patients undergoing VATS lung wedge resections were randomized into two groups (SAPB and control): both received intravenous patient-controlled analgesia (PCA), and one group received additional SAPB. The primary outcome was the cumulative intravenous fentanyl consumption at 8 h postoperatively. The visual analog scale (VAS) pain scores and the incidence of postoperative complications were assessed over 48 h post surgery. Results: Fentanyl consumption by 8 h post surgery was significantly lower in the SAPB group than in the control group (183 \u00b1 107 \u03bcg vs. 347 \u00b1 202 \u03bcg, p = 0.035). Although the VAS scores decreased with time in both groups, the differences were not statistically significant. The SAPB group required fewer opioids by 48 h. No significant between-group differences were observed in postoperative complications, including nausea and vomiting. Conclusions: SAPB effectively reduced opioid consumption after VATS lung wedge resection. SABP may serve as a valuable component of multimodal pain management.<\/jats:p>","DOI":"10.3390\/medicina61010011","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T03:10:49Z","timestamp":1735182649000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of a Serratus Anterior Plane Block After Video-Assisted Lung Wedge Resection: A Single-Center, Prospective, and Randomized Controlled Trial"],"prefix":"10.3390","volume":"61","author":[{"given":"Seokjin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon 35365, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0714-1477","authenticated-orcid":false,"given":"Tae-Yun","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon 35365, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choon-Kyu","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon 35365, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyuwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon 35365, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-5677","authenticated-orcid":false,"given":"Woojin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon 35365, Republic of Korea"},{"name":"Myunggok Medical Research Institute, Konyang University Hospital, Konyang University College of Medicine, Daejeon 35365, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1911793","article-title":"Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial","volume":"382","author":"Scholten","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/vats.2020.01.02","article-title":"Does low-dose computed tomography screening improve lung cancer-related outcomes?\u2014A systematic review","volume":"5","author":"Yu","year":"2020","journal-title":"Video-Assist. Thorac. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0003-4975(01)02804-1","article-title":"Pulmonary function, postoperative pain, and serum cytokine level after lobectomy: A comparison of VATS and conventional procedure","volume":"72","author":"Nagahiro","year":"2001","journal-title":"Ann. Thorac. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12630-011-9475-9","article-title":"Postoperative analgesia after minimally invasive thoracoscopy: What should we do?","volume":"58","author":"Neustein","year":"2011","journal-title":"Can. J. Anaesth."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/ALN.0000000000001576","article-title":"A Prospective Study of Chronic Pain after Thoracic Surgery","volume":"126","author":"Bayman","year":"2017","journal-title":"Anesthesiology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.aat.2012.08.004","article-title":"Patient-controlled analgesia (PCA) following video-assisted thoracoscopic lobectomy: Comparison of epidural PCA and intravenous PCA","volume":"50","author":"Yie","year":"2012","journal-title":"Acta Anaesthesiol. Taiwan."},{"unstructured":"Gropper, M.A., Eriksson, L.I., Fleisher, L.A., Wiener-Kronish, J.P., Cohen, N.H., and Leslie, K. (2019). Miller\u2019s Anesthesia, Elsevier. [9th ed.].","key":"ref_8"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/ejcts\/ezt525","article-title":"Regional analgesia for video-assisted thoracic surgery: A systematic review","volume":"45","author":"Steinthorsdottir","year":"2014","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/00000542-200603000-00027","article-title":"Preventing and treating pain after thoracic surgery","volume":"104","author":"Gottschalk","year":"2006","journal-title":"Anesthesiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/j.jvca.2016.08.023","article-title":"Ultrasound-Guided Serratus Anterior Plane Block Versus Thoracic Epidural Analgesia for Thoracotomy Pain","volume":"31","author":"Khalil","year":"2017","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1053\/j.jvca.2011.07.026","article-title":"Comparison of the analgesic effects of continuous extrapleural block and continuous epidural block after video-assisted thoracoscopic surgery","volume":"25","author":"Hotta","year":"2011","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/anae.12344","article-title":"Serratus plane block: A novel ultrasound-guided thoracic wall nerve block","volume":"68","author":"Blanco","year":"2013","journal-title":"Anaesthesia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/anae.13549","article-title":"An anatomical evaluation of the serratus anterior plane block","volume":"71","author":"Mayes","year":"2016","journal-title":"Anaesthesia"},{"key":"ref_15","first-page":"E421","article-title":"Serratus anterior plane block: A new analgesic technique for post-thoracotomy pain","volume":"18","author":"Madabushi","year":"2015","journal-title":"Pain. Physician"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jclinane.2016.05.029","article-title":"The effect of serratus plane block performed under direct vision on postoperative pain in breast surgery","volume":"34","author":"Hards","year":"2016","journal-title":"J. Clin. Anesth."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jclinane.2019.01.019","article-title":"Serratus anterior plane block for minimally invasive valve surgery thoracotomy pain","volume":"56","author":"Kazior","year":"2019","journal-title":"J. Clin. Anesth."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00540-017-2364-9","article-title":"The efficacy of serratus anterior plane block in analgesia for thoracotomy: A retrospective study","volume":"31","year":"2017","journal-title":"J. Anesth."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.bja.2021.11.032","article-title":"Utility of unidimensional and functional pain assessment tools in adult postoperative patients: A systematic review","volume":"128","author":"Baamer","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1213\/00000539-199912000-00038","article-title":"The pain visual analog scale: Is it linear or nonlinear?","volume":"89","author":"Myles","year":"1999","journal-title":"Anesth. Analg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/0310057X0503300108","article-title":"The linearity of the visual analogue scale in patients with severe acute pain","volume":"33","author":"Myles","year":"2005","journal-title":"Anaesth. Intensive Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1213\/ANE.0000000000002779","article-title":"Efficacy of Ultrasound-Guided Serratus Plane Block on Postoperative Quality of Recovery and Analgesia After Video-Assisted Thoracic Surgery: A Randomized, Triple-Blind, Placebo-Controlled Study","volume":"126","author":"Kim","year":"2018","journal-title":"Anesth. Analg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.2147\/JPR.S207116","article-title":"Effects of serratus anterior plane block for postoperative analgesia after thoracoscopic surgery compared with local anesthetic infiltration: A randomized clinical trial","volume":"12","author":"Chen","year":"2019","journal-title":"J. Pain Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2147\/JPR.S191263","article-title":"Ultrasound-guided serratus anterior plane block for analgesia after thoracic surgery","volume":"12","author":"Semyonov","year":"2019","journal-title":"J. Pain Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/AAP.0000000000000555","article-title":"\u201cA Tale of Two Planes\u201d: Deep Versus Superficial Serratus Plane Block for Postmastectomy Pain Syndrome","volume":"42","author":"Piracha","year":"2017","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_26","first-page":"480","article-title":"Too Deep or Not Too Deep?: A Propensity-Matched Comparison of the Analgesic Effects of a Superficial Versus Deep Serratus Fascial Plane Block for Ambulatory Breast Cancer Surgery","volume":"43","author":"Abdallah","year":"2018","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s12630-019-01340-9","article-title":"Cadaveric findings of the effect of rib fractures on spread of serratus plane injections","volume":"66","author":"Johnston","year":"2019","journal-title":"Can. J. Anaesth."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1136\/rapm-2020-102098","article-title":"Serratus anterior plane block for posterior rib fractures: Why and when may it work?","volume":"46","author":"Almeida","year":"2021","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.accpm.2017.09.005","article-title":"Evaluation of the effect of serratus anterior plane block for pain treatment after video-assisted thoracoscopic surgery","volume":"37","year":"2018","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/anae.14424","article-title":"A randomised trial of serratus anterior plane block for analgesia after thoracoscopic surgery","volume":"73","author":"Park","year":"2018","journal-title":"Anaesthesia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/icvts\/ivz289","article-title":"Serratus plane block for video-assisted thoracoscopic surgery major lung resection: A randomized controlled trial","volume":"30","author":"Viti","year":"2020","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bjae.2021.11.008","article-title":"Chronic post-surgical pain\u2014Update on incidence, risk factors and preventive treatment options","volume":"22","author":"Rosenberger","year":"2022","journal-title":"BJA Educ."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1053\/j.jvca.2011.04.010","article-title":"Acute pain management for video-assisted thoracoscopic surgery: An update","volume":"26","author":"Kaplowitz","year":"2012","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/00002508-199603000-00009","article-title":"Acute pain after thoracic surgery predicts long-term post-thoracotomy pain","volume":"12","author":"Katz","year":"1996","journal-title":"Clin. J. Pain"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/anae.15609","article-title":"PROSPECT guidelines for video-assisted thoracoscopic surgery: A systematic review and procedure-specific postoperative pain management recommendations","volume":"77","author":"Feray","year":"2022","journal-title":"Anaesthesia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.bja.2020.06.020","article-title":"Comparing erector spinae plane block with serratus anterior plane block for minimally invasive thoracic surgery: A randomised clinical trial","volume":"125","author":"Finnerty","year":"2020","journal-title":"Br. J. Anaesth."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/1\/11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:00:17Z","timestamp":1760115617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["medicina61010011"],"URL":"https:\/\/doi.org\/10.3390\/medicina61010011","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2024,12,26]]}}}