{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:04:38Z","timestamp":1790935478026,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Medicine Research Fund of Chiang Mai University","award":["057\/2567"],"award-info":[{"award-number":["057\/2567"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Spinocerebellar ataxia (SCA) is a progressive neurodegenerative disease often accompanied by depression. This cross-sectional study investigated the prevalence of depression and the associated mental health factors in SCA patients. Material and Methods: Eleven Thai SCA patients completed questionnaires assessing depression, anxiety, inner strengths, perceived social support, personality traits and perceived stress. Results: Participants\u2019 average age was 50.27 years old. The prevalence of depression was 27.27%. Depression scores were positively correlated with OI-anxiety score (r = 0.887, 95%CI 0.586 to 0.968), perceived stress (r = 0781, 95%CI 0.305 to 0.936) and personality traits including aggression (r = 0.73, 95% CI 0.197 to 0.920), activity (r = 0.651, 95%CI 0.052 to 0.893) and neuroticism (r = 0.80, 95% CI 0.351 to 0.942). Conversely, depression negatively correlated with inner strengths (r = \u22120.70, 95%CI \u22120.910 to \u22120.139) and perceived social support, particularly from family (r = \u22120.88, 95%CI \u22120.966 to \u22120.564). Conclusions: These findings highlight the need for comprehensive mental health assessment and intervention in SCA patients. Strengthening inner strengths, promoting social support, and managing negative mental health factors may improve quality of life for patients with SCA.<\/jats:p>","DOI":"10.3390\/medicina61010160","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T04:04:12Z","timestamp":1737345852000},"page":"160","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Depression and Associated Factors Among Patients with Spinocerebellar Ataxia"],"prefix":"10.3390","volume":"61","author":[{"given":"Sirivipa","family":"Jekpoo","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8365-2474","authenticated-orcid":false,"given":"Nahathai","family":"Wongpakaran","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9062-3468","authenticated-orcid":false,"given":"Tinakon","family":"Wongpakaran","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7201-5517","authenticated-orcid":false,"given":"Chayasak","family":"Wantaneeyawong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-9054","authenticated-orcid":false,"given":"Punjaree","family":"Wiriyacosol","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pised","family":"Methapatara","sequence":"additional","affiliation":[{"name":"Suanprug Hospital, Chang Wat Ratchaburi 70180, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00415-018-9076-4","article-title":"Spinocerebellar ataxia: An update","volume":"266","author":"Sullivan","year":"2019","journal-title":"J. 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