{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:32:45Z","timestamp":1791891165325,"version":"4.3.4"},"reference-count":128,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Lymphedema is a chronic condition characterized by the accumulation of lymphatic fluid in the tissues, causing swelling primarily in the limbs, though other body parts can also be affected. It commonly develops after lymph node removal, or radiation therapy, or due to congenital lymphatic system defects. Effective management is essential due to its significant impact on physical function and quality of life. Complete Decongestive Therapy (CDT) is the primary treatment for lymphedema. This comprehensive approach combines manual lymphatic drainage (MLD), compression bandaging, skincare, and exercise. An early diagnosis and initiation of CDT are critical to preventing irreversible damage to the lymphatic system and worsening symptoms. Successful outcomes depend on timely treatment, patient adherence, and the consistent use of all CDT components, with compression therapy and exercise playing particularly vital roles. Recent research highlights how skin and fat tissue characteristics, such as increased skin thickness and adipose tissue accumulation, complicate lymphedema management, especially in advanced stages. In these cases, where fibrosis and fat deposition are more prominent, traditional CDT may need to be supplemented with advanced treatments like liposuction or enhanced compression techniques. This study explores the factors influencing the success of decongestive therapy, including the stage of lymphedema at the diagnosis, treatment protocols, and individual patient characteristics like skin and fat tissue properties.<\/jats:p>","DOI":"10.3390\/medicina61020231","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T09:42:23Z","timestamp":1737970943000},"page":"231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Predictors of the Efficacy of Lymphedema Decongestive Therapy"],"prefix":"10.3390","volume":"61","author":[{"given":"Andrej","family":"Dzupina","sequence":"first","affiliation":[{"name":"Department of Angiology, National Heart Institute, 833 48 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagendra","family":"Yaluri","sequence":"additional","affiliation":[{"name":"Centre of Clinical and Preclinical Research MEDIPARK, Pavol Jozef Safarik University, 040 01 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaipaul","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Jankajova","sequence":"additional","affiliation":[{"name":"Cardiology Department, Kardiocentrum Agel-Saca a.s., L\u00fa\u010dna 57\/040 15, 040 15 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.cmet.2017.07.020","article-title":"Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity","volume":"26","author":"Escobedo","year":"2017","journal-title":"Cell Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.5606\/tftrd.2018.3539","article-title":"Lymphedema Diagnosis, Treatment, and Follow-up from the View Point of Physical Medicine and Rehabilitation Specialists","volume":"64","author":"Borman","year":"2018","journal-title":"Turk. 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