{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:31:12Z","timestamp":1781263872387,"version":"3.54.1"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Age-related macular degeneration (AMD) remains a leading cause of legal blindness. Anti-Vascular Endothelial Growth Factor (VEGF) agents are the first-line treatment for neovascular AMD (nAMD). The choroid plays a key role in AMD and is affected by the anti-VEGF treatment. Faricimab, a bispecific antibody additionally targeting angiopoietin 2 (Ang2), was recently approved for nAMD treatment. This study investigates the effect of Faricimab on choroidal flow signal. Materials and Methods: Optical coherence tomography angiography images of 29 nAMD eyes were examined retrospectively. Patients had received treatment with other anti-VEGF agents before Faricimab application. The flow signal in the choroid was measured before, after one and after a series of \u22652 Faricimab injections. Results: The flow signal decreased significantly (p = 0.026) at the choriocapillaris (CC) level after \u22652 injections. The flow signal did not show a significant change in Haller\u2019s layer but increased slightly in Sattler\u2019s layer (p = 0.034). Conclusions: In conclusion, our results show that the flow signal, especially at the CC level, changed during treatment. Despite the known influence of anti-VEGF treatment on the choroid, auxiliary inhibition of Ang2 might enhance this effect. Due to the retrospective nature, moderate sample size and non-treatment, na\u00efve patients, care must be taken while interpreting our observations. Prospective studies with larger sample sizes and treatment-na\u00efve patients will be needed.<\/jats:p>","DOI":"10.3390\/medicina61020260","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T08:47:57Z","timestamp":1738572477000},"page":"260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optical Coherence Tomography Angiography Flow Signal in Non-Treatment-Na\u00efve Patients with Neovascular Age-Related Macular Degeneration Treated with Faricimab"],"prefix":"10.3390","volume":"61","author":[{"given":"Max","family":"Brinkmann","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Klinikum Klagenfurt, 9020 Klagenfurt, Austria"},{"name":"Department of Ophthalmology, Universit\u00e4tsklinikum Schleswig-Holstein, 23564 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9204-4898","authenticated-orcid":false,"given":"Tom","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Klinikum Klagenfurt, 9020 Klagenfurt, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"K\u00f6ster","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Schweighofer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universit\u00e4tsklinikum Wiener Neustadt, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathis","family":"Danckwardt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universit\u00e4tsklinikum Schleswig-Holstein, 23564 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2617-0289","authenticated-orcid":false,"given":"Giuseppe","family":"Giannaccare","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8881-0926","authenticated-orcid":false,"given":"Paola","family":"Marolo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-5031","authenticated-orcid":false,"given":"Enrico","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1368-6729","authenticated-orcid":false,"given":"Michele","family":"Reibaldi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuf","family":"El-Shabrawi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Klinikum Klagenfurt, 9020 Klagenfurt, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Damiano","family":"Toro","sequence":"additional","affiliation":[{"name":"Eye Clinic, Public Health Department, University of Naples Federico II, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: A systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Vos","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Arruabarrena, C., Toro, M.D., Onen, M., Malyugin, B.E., Rejdak, R., Tognetto, D., Zweifel, S., Giglio, R., and Teus, M.A. (2021). 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