{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:17:53Z","timestamp":1760426273514,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Familial Mediterranean fever (FMF) is a lifelong autoinflammatory disease characterized by episodes of fever and aseptic polyserositis. Commonly associated with vasculitis, FMF\u2019s impact on microcirculation was investigated by examining nailfold capillaries using capillaroscopy. Materials and Methods: This study included 32 female and 28 male FMF patients diagnosed according to the Tel Hashomer and Yal\u00e7\u0131nkaya criteria and a control group of 20 female and 10 male age-matched cases. Demographic characteristics, medical history (abdominal pain, fever, chest pain, and joint pain), and physical examination findings of the cases were assessed. FMF gene mutations, acute-phase reactants, urine analysis, and spot urine protein\/creatinine ratios were evaluated. Nailfold capillaries were examined via capillaroscopy by the same dermatology specialist. Results: There was no significant age or gender difference between groups. The most common symptoms in the case group were abdominal pain (81.7%) and joint pain (65%). Pathological findings in capillaroscopy, such as microhemorrhages and avascular areas, were significantly more frequent in the FMF case group (p &lt; 0.001; p &lt; 0.001). Physiological findings, including hairpin-shaped capillaries and shortened loops, were significantly more common in the control group (p = 0.001; p = 0.034). No significant relationships were found between kidney involvement, subclinical inflammation, presence of microhemorrhages and avascular areas in capillaroscopy, and disease duration. Additionally, no significant differences were observed in capillaroscopic findings between those with exon-10 mutations in the MEFV gene and those with non-exon-10 mutations. Conclusions: In conclusion, our study demonstrated secondary microvascular findings due to inflammation in FMF patients using capillaroscopy, a cost-effective and safe tool.<\/jats:p>","DOI":"10.3390\/medicina61020264","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T10:57:53Z","timestamp":1738666673000},"page":"264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of Microvascular Involvement Through Nailfold Capillaroscopic Examination in Children with Familial Mediterranean Fever"],"prefix":"10.3390","volume":"61","author":[{"given":"Fatih","family":"Kurt","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Duzce University, 81620 Duzce, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-6760","authenticated-orcid":false,"given":"Belk\u0131z","family":"Uyar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Duzce University, 81620 Duzce, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muferet","family":"Erguven","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Duzce University, 81620 Duzce, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sengul","family":"Cangur","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Duzce University, 81620 Duzce, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00296-019-04457-8","article-title":"Familial Mediterranean fever and atherosclerosis in childhood and adolescence","volume":"40","author":"Vampertzi","year":"2020","journal-title":"Rheumatol. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00383-022-05153-8","article-title":"Familial Mediterranean fever may mimic acute appendicitis in children","volume":"38","author":"Wekell","year":"2022","journal-title":"Pediatr. Surg. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1093\/rheumatology\/kez410","article-title":"Comorbidities in familial Mediterranean fever: Analysis of 2000 genetically confirmed patients","volume":"59","author":"Kalyoncu","year":"2020","journal-title":"Rheumatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1093\/rheumatology\/keaa450","article-title":"Familial Mediterranean fever: The molecular pathways from stress exposure to attacks","volume":"59","author":"Korkmaz","year":"2020","journal-title":"Rheumatology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.5152\/TurkArchPediatr.2022.21368","article-title":"Neurological face of familial Mediterranean fever","volume":"57","author":"Tufan","year":"2022","journal-title":"Turk. Arch. Pediatr."},{"doi-asserted-by":"crossref","unstructured":"Abbara, S., Grateau, G., Ducharme-B\u00e9nard, S., Saadoun, D., and Georgin-Lavialle, S. (2019). Association of vasculitis and familial Mediterranean fever. Front. Immunol., 10.","key":"ref_6","DOI":"10.3389\/fimmu.2019.00763"},{"doi-asserted-by":"crossref","unstructured":"Smith, V., Herrick, A.L., Ingegnoli, F., Damjanov, N., De Angelis, R., Denton, C.P., Distler, O., Espejo, K., Foeldvari, I., and Frech, T. (2020). Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud\u2019s phenomenon and systemic sclerosis. Autoimmun. Rev., 19.","key":"ref_7","DOI":"10.1016\/j.autrev.2020.102458"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/art.1780401023","article-title":"Criteria for the diagnosis of familial Mediterranean fever","volume":"40","author":"Livneh","year":"1997","journal-title":"Arthritis Rheum."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.25259\/IJDVL_514_20","article-title":"Nail-fold capillaroscopy for the dermatologists","volume":"88","author":"Grover","year":"2022","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/rheumatology\/ken509","article-title":"A new set of criteria for the diagnosis of familial Mediterranean fever in childhood","volume":"48","author":"Aktay","year":"2009","journal-title":"Rheumatology"},{"doi-asserted-by":"crossref","unstructured":"Lazar, L.T., Guldberg-M\u00f8ller, J., Lazar, B.T., and Mogensen, M. (2023). Nailfold capillaroscopy as diagnostic test in patients with psoriasis and psoriatic arthritis: A systematic review. Microvasc. Res., 147.","key":"ref_11","DOI":"10.1016\/j.mvr.2023.104476"},{"key":"ref_12","first-page":"930","article-title":"Nailfold capillary microscopy in the connective tissue diseases: A semiquantitative assessment","volume":"10","author":"Lee","year":"1983","journal-title":"J. Rheumatol."},{"key":"ref_13","first-page":"S42","article-title":"Nailfold capillary abnormalities in patients with familial Mediterranean fever","volume":"19","author":"Dinc","year":"2001","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.autrev.2017.11.025","article-title":"Nailfold capillaroscopy in systemic lupus erythematosus: A systematic review and critical appraisal","volume":"17","author":"Cutolo","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.5114\/reum.2015.51508","article-title":"Raynaud\u2019s phenomenon: New aspects of pathogenesis and the role of nailfold videocapillaroscopy","volume":"53","author":"Kita","year":"2015","journal-title":"Reumatologia\/Rheumatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00467-019-04405-5","article-title":"Correlation of urine protein\/creatinine ratios to 24-h urinary protein for quantitating proteinuria in children","volume":"35","author":"Huang","year":"2020","journal-title":"Pediatr. Nephrol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10067-022-06358-x","article-title":"Can RDW be used as a screening test for subclinical inflammation in children with FMF? Is RDW related to MEFV gene mutations?","volume":"42","author":"Noyan","year":"2023","journal-title":"Clin. Rheumatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gene.2017.05.013","article-title":"MEFV mutations and their relation to major clinical symptoms of Familial Mediterranean Fever","volume":"626","author":"Cekin","year":"2017","journal-title":"Gene"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejim.2023.05.015","article-title":"Genetic and clinical features of familial mediterranean fever (FMF) in a homogeneous cohort of patients from South-Eastern Italy","volume":"115","author":"Iacoviello","year":"2023","journal-title":"Eur. J. Intern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/RHU.0000000000001134","article-title":"The value of serum amyloid A levels in familial Mediterranean fever to identify occult inflammation during asymptomatic periods","volume":"27","author":"Tanatar","year":"2021","journal-title":"JCR J. Clin. Rheumatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1016\/j.lpm.2018.08.014","article-title":"Familial Mediterranean Fever","volume":"48","author":"Ozdogan","year":"2019","journal-title":"Presse Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s10067-013-2257-8","article-title":"Mean platelet volume as a potential predictor of proteinuria and amyloidosis in familial Mediterranean fever","volume":"32","author":"Kal","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11926-018-0788-3","article-title":"Autoinflammatory disease-associated vasculitis\/vasculopathy","volume":"20","author":"Alghamdi","year":"2018","journal-title":"Curr. Rheumatol. Rep."},{"doi-asserted-by":"crossref","unstructured":"Karaca, E.E., Ozek, D., Omma, A., and Evren Kemer, O. (2019). Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals. Ther. Adv. Ophthalmol., 11.","key":"ref_24","DOI":"10.1177\/2515841419892056"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10067-010-1609-x","article-title":"Evaluation of nailfold capillaries in familial Mediterranean fever patients","volume":"30","author":"Aytekin","year":"2011","journal-title":"Clin. Rheumatol."},{"key":"ref_26","first-page":"70","article-title":"Nail fold capillary abnormality and insulin resistance in children with familial Mediterranean fever: Is there any relationship between vascular changes and insulin resistance?","volume":"40","author":"Dursun","year":"2018","journal-title":"J. Clin. Pract. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1097\/RHU.0000000000001632","article-title":"Compliance of Familial Mediterranean Fever Patients with Regular Follow-up Visits and Associated Factors","volume":"28","author":"Salman","year":"2022","journal-title":"JCR J. Clin. Rheumatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/10623320601061862","article-title":"The endothelium and inflammation","volume":"13","author":"Trepels","year":"2006","journal-title":"Endothelium"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/2\/264\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:26:46Z","timestamp":1760027206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/2\/264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["medicina61020264"],"URL":"https:\/\/doi.org\/10.3390\/medicina61020264","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2025,2,4]]}}}