{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T03:52:19Z","timestamp":1769313139895,"version":"3.49.0"},"reference-count":56,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: POSEIDON 4 (P4) patients face the most adverse outcomes among poor responders. Oocyte donation has overcome unsatisfactory live birth rates (LBRs) in P4 patients and has become an indispensable approach. However, many patients refuse oocyte donation despite poor live birth likelihood using autologous oocytes. This study aimed to determine clinical outcomes and live birth chances in P4 patients using autologous and donated oocytes. We also identified influencing factors of fertility outcome in P4 patients who underwent donor cycles. Materials and Methods: Retrospective data of 345 P4 patients who explored the first ovarian stimulation cycle (control group) were compared to 105 patients who failed to conceive and underwent repeated autologous ovarian stimulations with an increased starting gonadotropin dose and 100 unpregnant patients who received donated oocytes. Univariate analysis was used to identify prognostic factors of oocyte donation outcomes in P4 patients. Results: LBRs were significantly higher in the donor oocyte group. A higher number of retrieved and good-quality oocytes without differences in the blastocyst number and LBRs were found in the autologous patient group with adjusted gonadotropin dose compared to the control group. Univariate analysis showed that oocyte and embryo quality as well as blastocyst development had a positive impact on live birth in the donor patient group. Conclusions: Autologous in vitro fertilization (IVF) retreating and oocyte donation should be strongly advised for poor-prognosis P4 patients. Still, efforts in tailoring ovarian stimulation to obtain higher oocyte and embryo numbers in autologous cycles should be continued.<\/jats:p>","DOI":"10.3390\/medicina61020303","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T06:43:07Z","timestamp":1739169787000},"page":"303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In Vitro Fertilization Outcomes in Donor Oocyte Cycles Compared to the Autologous Cycles in the Poseidon 4 Group of Poor Ovarian Responders"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2642-4575","authenticated-orcid":false,"given":"Jelena","family":"Havrljenko","sequence":"first","affiliation":[{"name":"Ferona Fertility Clinic, Sarplaninska 19, 21000 Novi Sad, Serbia"},{"name":"Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Kopitovic","sequence":"additional","affiliation":[{"name":"Ferona Fertility Clinic, Sarplaninska 19, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra Trninic","family":"Pjevic","sequence":"additional","affiliation":[{"name":"Ferona Fertility Clinic, Sarplaninska 19, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stevan","family":"Milatovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5303-1731","authenticated-orcid":false,"given":"Sandro","family":"Kalember","sequence":"additional","affiliation":[{"name":"Ferona Fertility Clinic, Sarplaninska 19, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-0921","authenticated-orcid":false,"given":"Filip","family":"Katanic","sequence":"additional","affiliation":[{"name":"Ferona Fertility Clinic, Sarplaninska 19, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Pavlica","sequence":"additional","affiliation":[{"name":"Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nebojsa","family":"Andric","sequence":"additional","affiliation":[{"name":"Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-7723","authenticated-orcid":false,"given":"Kristina","family":"Pogrmic-Majkic","sequence":"additional","affiliation":[{"name":"Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"ref_1","first-page":"2633494120941480","article-title":"Update on the management of poor ovarian response in IVF: The shift from Bologna criteria to the Poseidon concept","volume":"14","author":"Drakopoulos","year":"2020","journal-title":"Ther. Adv. Rep. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1093\/humrep\/deab152","article-title":"Cumulative delivery rate per aspiration IVF\/ICSI cycle in POSEIDON patients: A real-world evidence study of 9073 patients","volume":"36","author":"Esteves","year":"2021","journal-title":"Hum. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"hoaa070","DOI":"10.1093\/hropen\/hoaa070","article-title":"POSEIDON classification and the proposed treatment options for groups 1 and 2: Time to revisit? A retrospective analysis of 1425 ART cycles","volume":"2021","author":"Chinta","year":"2021","journal-title":"Hum. Rep. Open"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Haahr, T., Dosouto, C., Alviggi, C., Esteves, S.C., and Humaidan, P. (2019). Management strategies for POSEIDON groups 3 and 4. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00614"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Harvey, A.J., Willson, B.E., Surrey, E.S., and Gardner, D.K. (Fertil. Steril., 2024). Ovarian stimulation protocols: Impact on oocyte and endometrial quality and function, Fertil. Steril., in press.","DOI":"10.1016\/j.fertnstert.2024.08.340"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.37506\/ijfmt.v15i4.16949","article-title":"How Can the Maternal Age and the Basal Level of Serum FSHPredict the ICSI Outcome?","volume":"15","author":"Mukheef","year":"2021","journal-title":"Ind. J. Foren. Med. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/ajo.13179","article-title":"Having a baby in your 40s with assisted reproductive technology: The reproductive dilemma of autologous versus donor oocytes","volume":"60","author":"Hogan","year":"2020","journal-title":"Aust. N. Z. J. Obstet. Gyn."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s10815-016-0701-9","article-title":"Is oocyte donation a risk factor for preeclampsia? A systematic reviewand meta- analysis","volume":"33","author":"Blazquez","year":"2016","journal-title":"J. Assist. Rep. Gen."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Caradeux, J., Fernandez, B., Avila, F., Valenzuela, A., Mondion, M., and Figueras, F. (2024). Pregnancies through oocyte donation. A mini review of pathways involved in placental dysfunction. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1338516"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10815-020-01880-w","article-title":"Donor egg is the best second choice for many infertile couples: Real progress in overcoming age- related fertility is not here yet","volume":"37","author":"Makhijani","year":"2020","journal-title":"J. Assist. Rep. Gen."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1093\/humrep\/deac113","article-title":"Increased versus standard gonadotrophin dosing in predicted poor responders of IVF: An open-label randomized controlled trial","volume":"37","author":"Liu","year":"2022","journal-title":"Hum. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1093\/humrep\/dex321","article-title":"Individualized FSH dosing based on ovarian reserve testing women starting IVF\/ICSI: A multicentre trial and cost-effectiveness analysis","volume":"32","author":"Oudshoorn","year":"2017","journal-title":"Hum. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lensen, S.F., Wilkinson, J., Leijdekkers, J.A., La Marca, A., Mol, B.W., Marjoribanks, J., Torrance, H., and Broekmans, F. (2018). Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilization plus intracytoplasmatic sperm injection (IVF\/ICSI). Cohran Database Syst. Rev.","DOI":"10.1002\/14651858.CD012693.pub2"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sunkara, S.K., Ramaraju, G.A., and Kamath, M.S. (2020). Management strategies for POSEIDON group 2. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00105"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Conforti, A., Esteves, S.C., Cimadomo, D., Vaiarelli, A., Di Rella, F., Ubaldi, F.M., Zullo, F., De Placido, G., and Alviggi, C. (2019). Management of women with an unexpected low ovarian response to gonadotropin. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00387"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/humrep\/del484","article-title":"Milder ovarian stimulation for in- vitro fertilization reduces aneuploidy in the human preimplantation embryo: A randomized controlled trial","volume":"22","author":"Baart","year":"2007","journal-title":"Hum. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103707","DOI":"10.1016\/j.ejmg.2019.103707","article-title":"Controlled ovarian hyperstimulation (COH) parameters associated with euploidy rates in donor oocytes","volume":"62","author":"McCulloh","year":"2019","journal-title":"Eur. J. Med. Gen."},{"key":"ref_18","first-page":"137","article-title":"Comparison of different stimulation protocols used in in vitro fertilization: A review","volume":"3","author":"Shrestha","year":"2015","journal-title":"Ann. Transl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Havrljenko, J., Kopitovic, V., Trninic Pjevic, A., Milatovic, S., Pavlica, T., Andric, N., and Pogrmic- Majkic, K. (2023). The prediction of IVF outcomes with autologous oocytes and the optimal MII oocyte\/embryo number for live birth at advanced maternal age. Medicina, 59.","DOI":"10.3390\/medicina59101799"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"i2","DOI":"10.1093\/humrep\/des200","article-title":"The oocyte","volume":"27","author":"Rienzi","year":"2012","journal-title":"Hum. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1007\/s43032-024-01596-7","article-title":"Vitrification of human oocytes before or after rescue-IVM does not impair maturation kinetics but induces meiotic spindle alterations","volume":"31","author":"Marteil","year":"2024","journal-title":"Rep. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Abu-Musa, A., Haahr, T., and Humaidan, P. (2020). Novel physiology and definition of poor ovarian response; clinical recommendations. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062110"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.fertnstert.2016.02.005","article-title":"A new more detailed stratification of low responders to ovarian stimulation: From a poor ovarian response to a low prognosis concept","volume":"105","author":"Alviggi","year":"2016","journal-title":"Fert. Steril."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.fertnstert.2017.03.007","article-title":"Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: A multicenter experience","volume":"107","author":"Ubaldi","year":"2017","journal-title":"Fert. Steril."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"26334941211024203","DOI":"10.1177\/26334941211024203","article-title":"Type and dose of gonadotropins in poor ovarian responders: Does it matter?","volume":"15","author":"Boudry","year":"2021","journal-title":"Therap. Adv. Rep. Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.fertnstert.2019.05.012","article-title":"Oocyte donor age has a significant impact on oocyte recipient\u2019s cumulative live- birth rate: A population- based cohort study","volume":"112","author":"Hogan","year":"2019","journal-title":"Fert. Steril."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1177\/1933719111432859","article-title":"Detrimental effect of high- dose gonadotropin on outcome of IVF: Making a case for gentle ovarian stimulation strategies","volume":"19","author":"Kovacs","year":"2014","journal-title":"Rep. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ijgo.14545","article-title":"Correlation of female age with outcome of IVF in low\/resource setting","volume":"161","author":"Adebayo","year":"2022","journal-title":"Int. J. Gyn. Obstet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1007\/s10815-018-1287-1","article-title":"Comparison of perinatal outcomes following frozen embryo transfer cycles using autologous vesus donor oocytes in women 40 to 43 years old: Analysis of SART CORS data","volume":"35","author":"Yu","year":"2018","journal-title":"J. Assist. Rep. Gen."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s10815-020-01847-x","article-title":"Why is use of donor eggs not viewed as treatment failure? A call for improvements in treatments with autologous oocytes","volume":"37","author":"Gleicher","year":"2020","journal-title":"J. Assist. Rep. Gen."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"0015","DOI":"10.1016\/j.fertnstert.2022.02.027","article-title":"When is the right time to stop autologous in vitro fertilization treatment in poor responders?","volume":"117","author":"Cakmak","year":"2022","journal-title":"Fert. Steril."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1007\/s10815-023-02888-8","article-title":"Dual trigger improves the pregnancy rate in fresh in vitro fertilization (IVF) cycles compared with the human chorionic gonadotropin (hCG) trigger: A systematic review and meta- analysis of randomized trials","volume":"40","author":"Hsia","year":"2023","journal-title":"J. Assit. Rep. Gen."},{"key":"ref_33","first-page":"112","article-title":"A mild ovarian stimulation strategy in women with poor ovarian reserve undergoing IVF: A multicenter randomized non- inferiority trial","volume":"32","author":"Youssef","year":"2017","journal-title":"Hum. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.fertnstert.2015.07.1151","article-title":"Gonadotropin dose is negatively correlated with live birth rate: Analysis of more than 650,000 assisted reproductive technology cycles","volume":"104","author":"Baker","year":"2015","journal-title":"Fert. Steril."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1007\/s10815-019-01609-4","article-title":"Preimplantation genetic testing for aneuploidy improves clinical, gestational, and neonatal outcomes in advanced maternal age patients without compromising cumulative live- birth rate","volume":"36","author":"Sacchi","year":"2019","journal-title":"J. Assist. Rep. Gen."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s10815-021-02227-9","article-title":"PGT- A: Who and when? A systematic review and network meta- analysis of RCTs","volume":"38","author":"Simopoulou","year":"2021","journal-title":"J. Assist. Rep. Gen."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1017\/S0967199421000204","article-title":"Live Birth and Clinical Outcome of Vitrification- Warming Donor Oocyte Programme: An Experience of a Single IVF Unit","volume":"29","author":"Sciorio","year":"2021","journal-title":"Zygote"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.fertnstert.2022.07.007","article-title":"Use of the endometrial receptivity array to guide personalized embryo transfer after a failed transfer attempt was associated with a lower cumulative and per transfer live birth rate during donor and autologous cycles","volume":"118","author":"Cozzolino","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.rbmo.2021.09.024","article-title":"Cumulative live birth rates in donor oocyte ICSI cycles are not improved by magnetic- activated cell sorting sperm selection","volume":"44","author":"Gil","year":"2022","journal-title":"Rep. Biomed. Online"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10815-020-02059-z","article-title":"Women utilizing oocyte donation have a decreased live birth rate if they displayed a low progesterone level in a previous hormonal replacement mock cycle","volume":"38","author":"Labrosse","year":"2021","journal-title":"J. Assist. Rep. Gen."},{"key":"ref_41","first-page":"3","article-title":"ART in Europe, 2018: Results generated from European registries by ESHRE. European IVF Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE)","volume":"2022","author":"Wyns","year":"2022","journal-title":"Hum. Reprod. Open"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ejogrb.2018.04.017","article-title":"Clinical outcomes of a vitrified donor oocyte programme: A single UK centre experience","volume":"225","author":"Seshadri","year":"2018","journal-title":"Eur. J. Obs. Gyn. Rep. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.fertnstert.2021.10.006","article-title":"Factors affecting live birth rates in donor oocytes from commercial egg banks vs. program egg donors: An analysis 0f 40,485 cycles from the Society for Assisted Reproductive Technology registry in 2016\u20132018","volume":"117","author":"Ellis","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13048-017-0378-4","article-title":"New national outcome data on fresh versus cryopreserved donor oocytes","volume":"11","author":"Kushnir","year":"2018","journal-title":"J. Ovarian Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1093\/humrep\/deaa178","article-title":"Efficiency and efficacy of vitrification in 35 654 sibling oocytes from donation cycles","volume":"35","author":"Rodriguez","year":"2020","journal-title":"Hum. Rep."},{"key":"ref_46","first-page":"68","article-title":"Oocyte donation: An overview","volume":"3","author":"Mahajan","year":"2017","journal-title":"Rep. Health"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"The Practice Committee of the American Society for Reproductive Medicine (2021). The American Society for Reproductive Medicine. Evidence-based outcomes after oocyte cryopreservation for donor oocyte in vitro fertilization andplanned oocyte cryopreservation: A guideline. Fertil. Steril., 116, 36\u201347.","DOI":"10.1016\/j.fertnstert.2021.02.024"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.fertnstert.2011.06.030","article-title":"Clinical application of oocyte vitrification: A systematic review and meta-analysis of randomized controlled trials","volume":"96","author":"Cobo","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kontopoulos, G., Simopoulou, M., Zervomanolakis, I., Prokopakis, T., Dimitropoulos, K., Dedoulis, E., Grigorakis, S., Agapitou, K., Nikitos, E., and Rapani, A. (2019). Cleavage stage versus blastocyst transfer in oocyte donation cycles. Medicina, 55.","DOI":"10.3390\/medicina55060293"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.rbmo.2022.01.001","article-title":"Blastocyst versus cleavage embryo transfer improves cumulative live birth rates, time and cost in oocyte recipients: A randomized controlled trial","volume":"44","author":"Clua","year":"2022","journal-title":"Rep. Biomed. Online"},{"key":"ref_51","first-page":"174","article-title":"Embryos from vitrified vs. fresh oocytes in an oocyte donation program: A comparative morhokinetic analysis","volume":"5","author":"Karagianni","year":"2024","journal-title":"F&F Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Gallardo, M., Goncalves, I., Redondo, J., Soares, A.P., Garrido, N., and Metello, J.L. (Fertil. Steril., 2024). Assesing the effect of below-benchmark vitrified\/warmed donor-oocyte survival rates in subsequent laboratory and clinical outcomes, Fertil. Steril., in press.","DOI":"10.1016\/j.fertnstert.2024.09.041"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.rbmo.2021.10.015","article-title":"Oocyte donation: Not all oocyte cryobanks are the same","volume":"44","author":"Gianaroli","year":"2022","journal-title":"Rep. Biomed. Online"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s13224-014-0515-6","article-title":"Estradiol level on day 2 and day of trigger: A potential predictor of the IVF-ET success","volume":"64","author":"Prasad","year":"2014","journal-title":"J. Obs. Gyn. India"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"s128","DOI":"10.1016\/S0015-0282(01)02376-7","article-title":"Day 2 estradiol and IVF outcome: The secret lies hidden above a treshold of 80 pg\/ml","volume":"76","author":"Tummon","year":"2001","journal-title":"Fertil. Steril."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/19396368.2015.1013645","article-title":"Can serum estradiol levels on the fourthday of IVF\/ICSI cycle predict outcome in poor responder women?","volume":"61","author":"Kahyaoglu","year":"2015","journal-title":"Syst. Biol. Rep. Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/2\/303\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:30:08Z","timestamp":1760027408000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/2\/303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["medicina61020303"],"URL":"https:\/\/doi.org\/10.3390\/medicina61020303","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]}}}