{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T06:05:18Z","timestamp":1770185118225,"version":"3.49.0"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Long COVID as a condition typically manifests itself three months after the initial onset of SARS-CoV-2 infection, with symptoms persisting for a minimum of two months. The aim of the present research was to identify potential predictors of post-COVID-19 syndrome (long COVID-19) and to evaluate factors associated with the presence of post-COVID-19 interstitial lung disease and functional decline. Materials and Methods: 210 patients hospitalized for confirmed SARS-CoV-2 infections mild, moderate, severe, and critical form have been evaluated at 3, 6 and twelve months. Results: Among them only one has been with a suspicion of interstitial lung disease after one year, the rest had no change in the lung. No risk factor from the baseline\/3-month or 6-month evaluations significantly influenced patients\u2019 status at 12 months. The longer the duration of hospitalization, the lower the FVC and DLCO were at 3 months, but the longer the duration of hospitalization, the higher the number of symptoms at 3 months and 6 months. In a multivariate linear regression analysis, the number of hospitalization days remained statistically significant only for the number of symptoms at 3 months and 6 months. Conclusions: Long COVID seems to be related to the severity of the initial disease, and among the most persistent. Post-COVID-19 interstitial lung disease does not seem to be a frequent entity, as in our study only 0.5% out of 210 patients had it.<\/jats:p>","DOI":"10.3390\/medicina61020304","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T06:43:07Z","timestamp":1739169787000},"page":"304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long COVID and Lung Involvement: A One-Year Longitudinal, Real-Life Study"],"prefix":"10.3390","volume":"61","author":[{"given":"Motoc Nicoleta","family":"Stefania","sequence":"first","affiliation":[{"name":"Department of Medical Sciences\u2014Pulmonology, Faculty of Medicine, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucuresti, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosmina Ioana","family":"Bondor","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, Faculty of Medicine, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Louis Pas-teur Str., no. 6, 400349 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta Victoriua","family":"Maria","sequence":"additional","affiliation":[{"name":"\u201cLeon Daniello\u201d, Clinical Hospital of Pulmonology, 400371 Cluj Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4538-9809","authenticated-orcid":false,"given":"Petrariu","family":"Florin","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Hygiene, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700946 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-842X","authenticated-orcid":false,"given":"Man Milena","family":"Adina","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences\u2014Pulmonology, Faculty of Medicine, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Man, M.A., Rajnoveanu, R.-M., Motoc, N.S., Bondor, C.I., Chis, A.F., Lesan, A., Puiu, R., Lucaciu, S.-R., Dantes, E., and Gergely-Domokos, B. (2021). Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and eosinophils correlation with high-resolution computer tomography severity score in COVID-19 patients. 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