{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T16:59:13Z","timestamp":1781974753146,"version":"3.54.5"},"reference-count":73,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Asthma is a reversible clinical condition characterized by airway obstruction due to bronchial smooth muscle contraction, inflammation and a hypersecretive state. Severe asthma exacerbations (SAE) may be a part of the natural history of this condition. Patients presenting with SAE are at higher risk of recurrent attacks, often nonresponsive to medical therapy and eventually requiring invasive mechanical ventilation (MV). The use of noninvasive respiratory supports (NRSs) may be beneficial in patients with SAE who are at risk of developing acute respiratory failure (ARF). However, their application is insufficiently supported by the evidence, as reports on their application in asthmatic patients are scarce and only a few retrospective studies with a limited number of participants have been published to date. This review discusses the potentialities of NRS in the treatment of SAE, with reference to the pathophysiological background and future perspectives on their use in asthma management.<\/jats:p>","DOI":"10.3390\/medicina61020328","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:10:22Z","timestamp":1739423422000},"page":"328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma Exacerbations"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5271-1810","authenticated-orcid":false,"given":"Giuseppe","family":"Cuttone","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Trauma Center, Azienda Ospedaliera \u201cOspedali Riuniti Villa Sofia\u2013Cervello\u201d, 90146 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-7554","authenticated-orcid":false,"given":"Luigi","family":"La Via","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care 1, University Hospital Policlinico \u201cG. Rodolico\u2013San Marco\u201d, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, University of Enna \u201cKore\u201d, 94100 Enna, Italy"},{"name":"Policlinico \u201cG.B. Morgagni\u201d, 95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9331-2788","authenticated-orcid":false,"given":"Massimiliano","family":"Sorbello","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, University of Enna \u201cKore\u201d, 94100 Enna, Italy"},{"name":"Department of Anaesthesia and Intensive Care, Giovanni Paolo II Hospital, 97100 Ragusa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0215-5620","authenticated-orcid":false,"given":"Daniele Salvatore","family":"Patern\u00f2","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Giovanni Paolo II Hospital, 97100 Ragusa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-0088","authenticated-orcid":false,"given":"Matteo","family":"Piattoli","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, 00185 Rome, Italy"},{"name":"Faculty of Medicine and Surgery, Saint Camillus International University of Health and Medical Sciences \u201cUniCamillus\u201d, 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Gregoretti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Saint Camillus International University of Health and Medical Sciences \u201cUniCamillus\u201d, 00131 Rome, Italy"},{"name":"Department of Anaesthesia and Intensive Care, Fondazione Istituto \u201cG. Giglio\u201d Cefal\u00f9, 90015 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Misseri","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Fondazione Istituto \u201cG. Giglio\u201d Cefal\u00f9, 90015 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref_1","unstructured":"Global Initiative for Asthma\u2014GINA (2024, September 07). 2024 GINA Main Report. 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