{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T02:57:52Z","timestamp":1778295472962,"version":"3.51.4"},"reference-count":65,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Deanship of Research at Jordan University of Science and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Alopecia areata (AA) is a common cell-mediated autoimmune disease of the hair follicle that results in hair loss patches, affecting males and females of all ages and ethnicities. Although its etiology is not fully understood, AA is hypothesized to have a multifactorial basis with a strong genetic association. This study aims to replicate the genetic association of several risk loci in the Jordanian population for the first time. Materials and Methods: Genomic DNA samples of 152 patients with AA and 150 control individuals were extracted from EDTA blood tubes collected from dermatology clinics, in addition to the clinical data of participants. Genetic sequencing of the 21 targeted risk loci was carried out using the Sequenom MassARRAY\u00ae system (iPLEX GOLD), and the results were statistically analyzed using the Statistical Package for the Social Sciences. Results: The results compared the distribution of alleles and genotypes and the association between control individuals and AA patients. However, our results do not support a significant association of all of the 21 SNPs in our AA cohort (p &gt; 0.05). Conclusions: Our data emphasize that AA has a varied genetic component between ethnic groups and suggest that other additional environmental and psychological triggers may be involved.<\/jats:p>","DOI":"10.3390\/medicina61030409","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T11:22:12Z","timestamp":1740568932000},"page":"409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigating the Genetic Association of Selected Candidate Loci with Alopecia Areata Susceptibility in Jordanian Patients"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0064-0190","authenticated-orcid":false,"given":"Laith N.","family":"AL-Eitan","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5167-4544","authenticated-orcid":false,"given":"Maryam K.","family":"Alasmar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6660-3352","authenticated-orcid":false,"given":"Hanan A.","family":"Aljamal","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad H.","family":"Mihyar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6613-1498","authenticated-orcid":false,"given":"Mansour A.","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, King Khalid University, Abha 62529, Saudi Arabia"},{"name":"Genomics and Personalized Medicine Unit, The Center for Medical and Health Research, King Khalid University, Abha 62529, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"ref_1","first-page":"389","article-title":"The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata","volume":"158","author":"Betz","year":"2008","journal-title":"Br. 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