{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:29:38Z","timestamp":1792646978838,"version":"4.5.0"},"reference-count":281,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD), the most prevalent form of dementia, is marked by progressive cognitive decline, affecting memory, language, orientation, and behavior. Pathological hallmarks include extracellular amyloid plaques and intracellular tau tangles, which disrupt synaptic function and connectivity. Neural oscillations, the rhythmic synchronization of neuronal activity across frequency bands, are integral to cognitive processes but become dysregulated in AD, contributing to network dysfunction and memory impairments. Targeting these oscillations has emerged as a promising therapeutic strategy. Preclinical studies have demonstrated that specific frequency modulations can restore oscillatory balance, improve synaptic plasticity, and reduce amyloid and tau pathology. In animal models, interventions, such as gamma entrainment using sensory stimulation and transcranial alternating current stimulation (tACS), have shown efficacy in enhancing memory function and modulating neuroinflammatory responses. Clinical trials have reported promising cognitive improvements with repetitive transcranial magnetic stimulation (rTMS) and deep brain stimulation (DBS), particularly when targeting key hubs in memory-related networks, such as the default mode network (DMN) and frontal\u2013parietal network. Moreover, gamma-tACS has been linked to increased cholinergic activity and enhanced network connectivity, which are correlated with improved cognitive outcomes in AD patients. Despite these advancements, challenges remain in optimizing stimulation parameters, individualizing treatment protocols, and understanding long-term effects. Emerging approaches, including transcranial pulse stimulation (TPS) and closed-loop adaptive neuromodulation, hold promise for refining therapeutic strategies. Integrating neuromodulation with pharmacological and lifestyle interventions may maximize cognitive benefits. Continued interdisciplinary efforts are essential to refine these approaches and translate them into clinical practice, advancing the potential for neural oscillation-based therapies in AD.<\/jats:p>","DOI":"10.3390\/medicina61030547","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T09:17:39Z","timestamp":1742462259000},"page":"547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Targeting Neural Oscillations for Cognitive Enhancement in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4629-6756","authenticated-orcid":false,"given":"Federica","family":"Palacino","sequence":"first","affiliation":[{"name":"Neurology Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Manganotti","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-6940","authenticated-orcid":false,"given":"Alberto","family":"Benussi","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer\u2019s disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer\u2019s disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/brain\/awad042","article-title":"Predicting amyloid PET and tau PET stages with plasma biomarkers","volume":"146","author":"Jack","year":"2023","journal-title":"Brain"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature20587","article-title":"Gamma frequency entrainment attenuates amyloid load and modifies microglia","volume":"540","author":"Iaccarino","year":"2016","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in alzheimer\u2019s disease: Synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/brain\/awl266","article-title":"Enhanced brain activity may precede the diagnosis of Alzheimer\u2019s disease by 30 years","volume":"129","author":"Mondadori","year":"2006","journal-title":"Brain"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1126\/science.83.2150.259","article-title":"Cortical excitatory state and variability in human brain rhythms","volume":"83","author":"Jasper","year":"1936","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrn.2016.141","article-title":"Network abnormalities and interneuron dysfunction in Alzheimer disease","volume":"17","author":"Palop","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature07150","article-title":"Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice","volume":"454","author":"Poulet","year":"2008","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1126\/science.1099745","article-title":"Neuronal oscillations in cortical networks","volume":"304","author":"Draguhn","year":"2004","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0304-3940(77)90024-6","article-title":"The cortical source of the alpha rhythm","volume":"6","year":"1977","journal-title":"Neurosci. Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0013-4694(73)90216-2","article-title":"Organization of thalamic and cortical alpha rhythms: Spectra and coherences","volume":"35","author":"Schrijer","year":"1973","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-0173(98)00056-3","article-title":"EEG alpha and theta oscillations reflect cognitive and memory performance: A review and analysis","volume":"29","author":"Klimesch","year":"1999","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/ejn.12453","article-title":"Neurosystems: Brain rhythms and cognitive processing","volume":"39","author":"Cannon","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/BF01797193","article-title":"\u00dcber das Elektrenkephalogramm des Menschen","volume":"87","author":"Berger","year":"1929","journal-title":"Arch. Psychiatr. Nervenkrankh."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fnhum.2010.00186","article-title":"Shaping Functional Architecture by Oscillatory Alpha Activity: Gating by Inhibition","volume":"4","author":"Jensen","year":"2010","journal-title":"Front. Hum. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"23772","DOI":"10.1073\/pnas.1913092116","article-title":"The generation and propagation of the human alpha rhythm","volume":"116","author":"Halgren","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/cercor\/12.8.877","article-title":"Oscillations in the alpha band (9\u201312 Hz) increase with memory load during retention in a short-term memory task","volume":"12","author":"Jensen","year":"2002","journal-title":"Cereb. Cortex"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/hbm.20306","article-title":"Parieto-occipital sources account for the increase in alpha activity with working memory load","volume":"28","author":"Tuladhar","year":"2007","journal-title":"Hum. Brain Mapp."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tins.2007.02.001","article-title":"New vistas for alpha-frequency band oscillations","volume":"30","author":"Palva","year":"2007","journal-title":"Trends Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1179\/147683008X301478","article-title":"Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress","volume":"11","author":"Baumeister","year":"2008","journal-title":"Nutr. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1002\/hbm.20759","article-title":"Oscillatory activity in parietal and dorsolateral prefrontal cortex during retention in visual short-term memory: Additive effects of spatial attention and memory load","volume":"30","author":"Grimault","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/hbm.20842","article-title":"Somatosensory working memory performance in humans depends on both engagement and disengagement of regions in a distributed network","volume":"31","author":"Haegens","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00221-006-0655-8","article-title":"Phasic increases in cortical beta activity are associated with alterations in sensory processing in the human","volume":"177","author":"Lalo","year":"2007","journal-title":"Exp. Brain Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuroscience.2008.06.061","article-title":"Response preparation and inhibition: The role of the cortical sensorimotor beta rhythm","volume":"156","author":"Zhang","year":"2008","journal-title":"Neuroscience"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Yaple, Z., Martinez-Saito, M., Novikov, N., Altukhov, D., Shestakova, A., and Klucharev, V. (2018). Power of Feedback-Induced Beta Oscillations Reflect Omission of Rewards: Evidence From an EEG Gambling Study. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00776"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"119373","DOI":"10.1016\/j.neuroimage.2022.119373","article-title":"The natural frequencies of the resting human brain: An MEG-based atlas","volume":"258","author":"Capilla","year":"2022","journal-title":"Neuroimage"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0074-7742(08)60266-4","article-title":"Responses from the Visual Cortex of Unanesthetized Monkeys","volume":"6","author":"Hughes","year":"1964","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yebeh.2008.01.011","article-title":"Gamma, fast, and ultrafast waves of the brain: Their relationships with epilepsy and behavior","volume":"13","author":"Hughes","year":"2008","journal-title":"Epilepsy Behav."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/hbm.23114","article-title":"Bihemispheric network dynamics coordinating vocal feedback control","volume":"37","author":"Kort","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn2044","article-title":"Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks","volume":"8","author":"Bartos","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"McCormick, D.A., McGinley, M., and Salkoff, D. (2014). Brain State Dependent Activity in the Cortex and Thalamus. Curr. Opin. Neurobiol., 31.","DOI":"10.1016\/j.conb.2014.10.003"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"14332","DOI":"10.1073\/pnas.1402773111","article-title":"Alpha and gamma oscillations characterize feedback and feedforward processing in monkey visual cortex","volume":"111","author":"Self","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0013-4694(87)90124-6","article-title":"Neural correlates of encoding in an incidental learning paradigm","volume":"67","author":"Paller","year":"1987","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1515\/REVNEURO.2005.16.3.239","article-title":"Cortical oscillatory activity and the dynamics of auditory memory processing","volume":"16","author":"Kaiser","year":"2005","journal-title":"Rev. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0079-6123(06)59019-3","article-title":"High-frequency gamma oscillations and human brain mapping with electrocorticography","volume":"159","author":"Crone","year":"2006","journal-title":"Prog. Brain Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.tins.2007.05.005","article-title":"The gamma cycle","volume":"30","author":"Fries","year":"2007","journal-title":"Trends Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/hbm.20750","article-title":"Task-related gamma-band dynamics from an intracerebral perspective: Review and implications for surface EEG and MEG","volume":"30","author":"Jerbi","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1523\/JNEUROSCI.0567-09.2010","article-title":"Hippocampal Gamma Oscillations Increase with Memory Load","volume":"30","author":"Litt","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"21834","DOI":"10.1073\/pnas.1914180116","article-title":"Directional coupling of slow and fast hippocampal gamma with neocortical alpha\/beta oscillations in human episodic memory","volume":"116","author":"Griffiths","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/0959-4388(95)80012-3","article-title":"Temporal structure in spatially organized neuronal ensembles: A role for interneuronal networks","volume":"5","author":"Chrobak","year":"1995","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1126\/science.7878473","article-title":"Storage of 7 \u00b1 2 short-term memories in oscillatory subcycles","volume":"267","author":"Lisman","year":"1995","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0896-6273(00)81085-5","article-title":"Relating hippocampal circuitry to function: Recall of memory sequences by reciprocal dentate-CA3 interactions","volume":"22","author":"Lisman","year":"1999","journal-title":"Neuron"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1111\/ejn.12606","article-title":"Functions of gamma-band synchronization in cognition: From single circuits to functional diversity across cortical and subcortical systems","volume":"39","author":"Bosman","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neuron.2015.09.034","article-title":"Rhythms for Cognition: Communication through Coherence","volume":"88","author":"Fries","year":"2015","journal-title":"Neuron"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0006-8993(93)90043-M","article-title":"Current source density analysis of the hippocampal theta rhythm: Associated sustained potentials and candidate synaptic generators","volume":"615","author":"Brankack","year":"1993","journal-title":"Brain Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.clinph.2005.12.027","article-title":"EEG theta rhythm in infants and preschool children","volume":"117","author":"Orekhova","year":"2006","journal-title":"Clin. Neurophysiol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hinterberger, T., Schmidt, S., Kamei, T., and Walach, H. (2014). Decreased electrophysiological activity represents the conscious state of emptiness in meditation. Front. Psychol., 5.","DOI":"10.3389\/fpsyg.2014.00099"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.biopsych.2021.08.020","article-title":"Midfrontal Theta Activity in Psychiatric Illness: An Index of Cognitive Vulnerabilities Across Disorders","volume":"91","author":"McLoughlin","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0896-6273(02)00586-X","article-title":"Theta oscillations in the hippocampus","volume":"33","year":"2002","journal-title":"Neuron"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.neubiorev.2015.09.018","article-title":"A systematic review of the neurophysiology of mindfulness on EEG oscillations","volume":"57","author":"Lomas","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/hipo.20116","article-title":"What is the function of hippocampal theta rhythm?\u2014Linking behavioral data to phasic properties of field potential and unit recording data","volume":"15","author":"Hasselmo","year":"2005","journal-title":"Hippocampus"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1126\/science.aat2952","article-title":"Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay","volume":"362","author":"Drieu","year":"2018","journal-title":"Science"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0896-6273(01)00186-6","article-title":"Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep","volume":"29","author":"Louie","year":"2001","journal-title":"Neuron"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1523\/JNEUROSCI.17-08-02807.1997","article-title":"Functional neuroanatomy of human slow wave sleep","volume":"17","author":"Maquet","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_57","first-page":"6S5-10","article-title":"The ultradian rhythm of sleep: Diverse relations with pituitary and adrenal hormones","volume":"159","author":"Brandenberger","year":"2003","journal-title":"Rev. Neurol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1162\/089976602753633358","article-title":"Stable propagation of activity pulses in populations of spiking neurons","volume":"14","author":"Kistler","year":"2002","journal-title":"Neural Comput."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nrn2979","article-title":"The role of phase synchronization in memory processes","volume":"12","author":"Fell","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/35094565","article-title":"Dynamic predictions: Oscillations and synchrony in top-down processing","volume":"2","author":"Engel","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.8235588","article-title":"Thalamocortical oscillations in the sleeping and aroused brain","volume":"262","author":"Steriade","year":"1993","journal-title":"Science"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1126\/science.275.5297.209","article-title":"A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons","volume":"275","author":"Magee","year":"1997","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0166-2236(00)01547-2","article-title":"Resonance, oscillation and the intrinsic frequency preferences of neurons","volume":"23","author":"Hutcheon","year":"2000","journal-title":"Trends Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/82910","article-title":"Dendritic coincidence detection of EPSPs and action potentials","volume":"4","author":"Stuart","year":"2001","journal-title":"Nat. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0896-6273(95)90094-2","article-title":"Bidirectional synaptic plasticity induced by a single burst during cholinergic theta oscillation in CA1 in vitro","volume":"15","author":"Huerta","year":"1995","journal-title":"Neuron"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0896-6273(02)01169-8","article-title":"Mechanisms of gamma oscillations in the hippocampus of the behaving rat","volume":"37","author":"Csicsvari","year":"2003","journal-title":"Neuron"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tins.2004.02.007","article-title":"Interneuron Diversity series: Circuit complexity and axon wiring economy of cortical interneurons","volume":"27","author":"Geisler","year":"2004","journal-title":"Trends Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nature01834","article-title":"Organization of cell assemblies in the hippocampus","volume":"424","author":"Harris","year":"2003","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0896-6273(03)00065-5","article-title":"Neuronal plasticity in thalamocortical networks during sleep and waking oscillations","volume":"37","author":"Steriade","year":"2003","journal-title":"Neuron"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1152\/physrev.00012.2003","article-title":"Interactions between membrane conductances underlying thalamocortical slow-wave oscillations","volume":"83","author":"Destexhe","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/hipo.22488","article-title":"Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning","volume":"25","year":"2015","journal-title":"Hippocampus"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1469-8986.1997.tb02128.x","article-title":"Theta synchronization and alpha desynchronization in a memory task","volume":"34","author":"Klimesch","year":"1997","journal-title":"Psychophysiology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0013-4694(94)90164-3","article-title":"Episodic and semantic memory: An analysis in the EEG theta and alpha band","volume":"91","author":"Klimesch","year":"1994","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.neubiorev.2007.03.005","article-title":"Event-related phase reorganization may explain evoked neural dynamics","volume":"31","author":"Klimesch","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3940(02)00225-2","article-title":"The interplay between theta and alpha oscillations in the human electroencephalogram reflects the transfer of information between memory systems","volume":"324","author":"Sauseng","year":"2002","journal-title":"Neurosci. Lett."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Jones, M.W., and Wilson, M.A. (2005). Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task. PLoS Biol., 3.","DOI":"10.1371\/journal.pbio.0030402"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuron.2008.09.014","article-title":"Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythm","volume":"60","author":"Sirota","year":"2008","journal-title":"Neuron"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1152\/physiol.00021.2010","article-title":"Gamma oscillations in the hippocampus","volume":"25","author":"Colgin","year":"2010","journal-title":"Physiology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.conb.2010.01.004","article-title":"Brain oscillations and memory","volume":"20","author":"Penny","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1515\/REVNEURO.2002.13.4.299","article-title":"The interaction of rhinal cortex and hippocampus in human declarative memory formation","volume":"13","author":"Fell","year":"2002","journal-title":"Rev. Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1162\/08989290260138636","article-title":"Modulation of induced gamma band responses in a perceptual learning task in the human EEG","volume":"14","author":"Gruber","year":"2002","journal-title":"J. Cogn. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0304-3940(00)01109-5","article-title":"Brain dynamics in theta and alpha frequency bands and working memory performance in humans","volume":"286","author":"Stam","year":"2000","journal-title":"Neurosci. Lett."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuroimage.2005.04.014","article-title":"Frontal midline EEG dynamics during working memory","volume":"27","author":"Onton","year":"2005","journal-title":"Neuroimage"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/cercor\/7.4.374","article-title":"High-resolution EEG mapping of cortical activation related to working memory: Effects of task difficulty, type of processing, and practice","volume":"7","author":"Gevins","year":"1997","journal-title":"Cereb. Cortex"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuron.2004.12.025","article-title":"Phase locking of single neuron activity to theta oscillations during working memory in monkey extrastriate visual cortex","volume":"45","author":"Lee","year":"2005","journal-title":"Neuron"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0079-6123(06)59004-1","article-title":"Principles of oscillatory brain dynamics and a treatise of recognition of faces and facial expressions","volume":"159","author":"Oniz","year":"2006","journal-title":"Prog. Brain Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0167-8760(00)00145-8","article-title":"Gamma, alpha, delta, and theta oscillations govern cognitive processes","volume":"39","year":"2001","journal-title":"Int. J. Psychophysiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1046\/j.1460-9568.2002.01975.x","article-title":"Frontal theta activity in humans increases with memory load in a working memory task","volume":"15","author":"Jensen","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.neuron.2018.09.023","article-title":"Working Memory 2.0","volume":"100","author":"Miller","year":"2018","journal-title":"Neuron"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.neuron.2014.03.013","article-title":"Slow and fast \u03b3 rhythms coordinate different spatial coding modes in hippocampal place cells","volume":"82","author":"Bieri","year":"2014","journal-title":"Neuron"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.neuron.2012.06.014","article-title":"Transient slow gamma synchrony underlies hippocampal memory replay","volume":"75","author":"Carr","year":"2012","journal-title":"Neuron"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"101555","DOI":"10.1016\/j.arr.2021.101555","article-title":"Toward noninvasive brain stimulation 2.0 in Alzheimer\u2019s disease","volume":"75","author":"Menardi","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12017-009-8109-7","article-title":"Functional alterations in memory networks in early Alzheimer\u2019s disease","volume":"12","author":"Sperling","year":"2010","journal-title":"Neuromol. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/cercor\/bhu260","article-title":"Oxygen Level and LFP in Task-Positive and Task-Negative Areas: Bridging BOLD fMRI and Electrophysiology","volume":"26","author":"Bentley","year":"2016","journal-title":"Cereb. Cortex"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000495945","article-title":"Non-Invasive Brain Stimulation in Dementia: A Complex Network Story","volume":"18","author":"Pini","year":"2018","journal-title":"Neurodegener. Dis."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.clinph.2006.01.020","article-title":"Frontal white matter volume and delta EEG sources negatively correlate in awake subjects with mild cognitive impairment and Alzheimer\u2019s disease","volume":"117","author":"Babiloni","year":"2006","journal-title":"Clin. Neurophysiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.brainres.2008.06.103","article-title":"A review of brain oscillations in cognitive disorders and the role of neurotransmitters","volume":"1235","year":"2008","journal-title":"Brain Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2009.07.003","article-title":"Amyloid deposition is associated with impaired default network function in older persons without dementia","volume":"63","author":"Sperling","year":"2009","journal-title":"Neuron"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJM200008173430701","article-title":"Patterns of brain activation in people at risk for Alzheimer\u2019s disease","volume":"343","author":"Bookheimer","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1126\/science.aac8128","article-title":"Reduced grid-cell-like representations in adults at genetic risk for Alzheimer\u2019s disease","volume":"350","author":"Kunz","year":"2015","journal-title":"Science"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/ana.22105","article-title":"Hippocampal hyperactivation in presymptomatic familial Alzheimer\u2019s disease","volume":"68","author":"Quiroz","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-2012-120907","article-title":"Phenotypic profile of early-onset familial Alzheimer\u2019s disease caused by presenilin-1 E280A mutation","volume":"32","author":"Glatzel","year":"2012","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuron.2012.03.023","article-title":"Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment","volume":"74","author":"Bakker","year":"2012","journal-title":"Neuron"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1212\/01.wnl.0000171450.97464.49","article-title":"Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD","volume":"65","author":"Dickerson","year":"2005","journal-title":"Neurology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.neuropsychologia.2008.01.026","article-title":"Altered deactivation in individuals with genetic risk for Alzheimer\u2019s disease","volume":"46","author":"Persson","year":"2008","journal-title":"Neuropsychologia"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/ana.20163","article-title":"Medial temporal lobe function and structure in mild cognitive impairment","volume":"56","author":"Dickerson","year":"2004","journal-title":"Ann. Neurol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.clinph.2007.12.002","article-title":"Global dynamical analysis of the EEG in Alzheimer\u2019s disease: Frequency-specific changes of functional interactions","volume":"119","author":"Jelles","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1460-9568.2007.05705.x","article-title":"Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP)","volume":"26","author":"Driver","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_109","unstructured":"(2024, December 08). Decreased Rhythmic GABAergic Septal Activity and Memory-Associated \u03b8 Oscillations After Hippocampal Amyloid-\u03b2 Pathology in the Rat, Available online: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6633464\/."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2174\/156720512802455403","article-title":"Amyloid beta 1-42 inhibits entorhinal cortex activity in the beta-gamma range: Role of GSK-3","volume":"9","author":"Ordaz","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/ejn.12233","article-title":"Alterations in hippocampal network oscillations and theta-gamma coupling arise before A\u03b2 overproduction in a mouse model of Alzheimer\u2019s disease","volume":"37","author":"Goutagny","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Klein, A.S., Donoso, J.R., Kempter, R., Schmitz, D., and Beed, P. (2016). Early Cortical Changes in Gamma Oscillations in Alzheimer\u2019s Disease. Front. Syst. Neurosci., 10.","DOI":"10.3389\/fnsys.2016.00083"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.neuron.2016.04.009","article-title":"Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples","volume":"90","author":"Gillespie","year":"2016","journal-title":"Neuron"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/hipo.22697","article-title":"Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer\u2019s disease","volume":"27","author":"Mably","year":"2017","journal-title":"Hippocampus"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1038\/s41467-019-13260-9","article-title":"Optogenetic gamma stimulation rescues memory impairments in an Alzheimer\u2019s disease mouse model","volume":"10","author":"Etter","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/archpsyc.1987.01800230073012","article-title":"Electroencephalographic spectra and coherence in the diagnosis of Alzheimer\u2019s-type and multi-infarct dementia. A pilot study","volume":"44","author":"Leuchter","year":"1987","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0197-4580(93)90089-T","article-title":"Regional spectral analysis of the REM sleep EEG in mild to moderate Alzheimer\u2019s disease","volume":"14","author":"Petit","year":"1993","journal-title":"Neurobiol. Aging"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0013-4694(94)90095-7","article-title":"EEG coherence in Alzheimer disease","volume":"90","author":"Besthorn","year":"1994","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/0006-3223(94)90023-X","article-title":"Reduced EEG coherence in dementia: State or trait marker?","volume":"35","author":"Dunkin","year":"1994","journal-title":"Biol. Psychiatry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0166-4328(95)00214-6","article-title":"Synaptic dysfunction in Alzheimer\u2019s disease: Clinical assessment using quantitative EEG","volume":"78","author":"Cook","year":"1996","journal-title":"Behav. Brain Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000119375","article-title":"Correlations of topographical EEG features with clinical severity in mild and moderate dementia of Alzheimer type","volume":"36","author":"Chiaramonti","year":"1997","journal-title":"Neuropsychobiology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00001756-199801050-00032","article-title":"EEG slowing and cerebrospinal fluid tau levels in patients with cognitive decline","volume":"9","author":"Jelic","year":"1998","journal-title":"Neuroreport"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0013-4694(97)00129-6","article-title":"EEG coherence in Alzheimer\u2019s disease","volume":"106","author":"Locatelli","year":"1998","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S1388-2457(99)00123-6","article-title":"EEG spectral profile to stage Alzheimer\u2019s disease","volume":"110","author":"Rodriguez","year":"1999","journal-title":"Clin. Neurophysiol."},{"key":"ref_126","unstructured":"(2024, December 07). Discrimination of Alzheimer\u2019s Disease and Mild Cognitive Impairment by Equivalent EEG Sources: A Cross-Sectional and Longitudinal Study, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/11068230\/."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00702-003-0024-8","article-title":"EEG coherence in Alzheimer\u2019s dementia","volume":"110","author":"Adler","year":"2003","journal-title":"J. Neural Transm."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0167-8760(03)00118-1","article-title":"Memory-related EEG power and coherence reductions in mild Alzheimer\u2019s disease","volume":"49","author":"Hogan","year":"2003","journal-title":"Int. J. Psychophysiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1388-2457(03)00345-6","article-title":"Individual analysis of EEG frequency and band power in mild Alzheimer\u2019s disease","volume":"115","author":"Moretti","year":"2004","journal-title":"Clin. Neurophysiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1631\/jzus.2005.B0259","article-title":"Abnormal cortical functional connections in Alzheimer\u2019s disease: Analysis of inter- and intra-hemispheric EEG coherence","volume":"6","author":"Jiang","year":"2005","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuroimage.2003.09.028","article-title":"Mapping distributed sources of cortical rhythms in mild Alzheimer\u2019s disease. A multicentric EEG study","volume":"22","author":"Babiloni","year":"2004","journal-title":"Neuroimage"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.neuroimage.2005.08.030","article-title":"Genotype (cystatin C) and EEG phenotype in Alzheimer disease and mild cognitive impairment: A multicentric study","volume":"29","author":"Babiloni","year":"2006","journal-title":"Neuroimage"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.brainres.2008.06.028","article-title":"Decrease of evoked delta, theta and alpha coherences in Alzheimer patients during a visual oddball paradigm","volume":"1235","author":"Yener","year":"2008","journal-title":"Brain Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.neurobiolaging.2006.12.019","article-title":"EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease","volume":"29","author":"Ponomareva","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00002093-199809000-00009","article-title":"Reduced interhemispheric EEG coherence in Alzheimer disease: Analysis during rest and photic stimulation","volume":"12","author":"Wada","year":"1998","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijpsycho.2006.07.006","article-title":"Increased frontal phase-locking of event-related theta oscillations in Alzheimer patients treated with cholinesterase inhibitors","volume":"64","author":"Yener","year":"2007","journal-title":"Int. J. Psychophysiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1468-1331.2008.02100.x","article-title":"Event-related delta oscillatory responses of Alzheimer patients","volume":"15","author":"Yener","year":"2008","journal-title":"Eur. J. Neurol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neurobiolaging.2005.07.021","article-title":"Prediction of longitudinal cognitive decline in normal elderly with subjective complaints using electrophysiological imaging","volume":"27","author":"Prichep","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/j.clinph.2006.05.034","article-title":"Enhanced magnetic auditory steady-state response in early Alzheimer\u2019s disease","volume":"117","author":"Osipova","year":"2006","journal-title":"Clin. Neurophysiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s00702-008-0083-y","article-title":"Increased EEG gamma band activity in Alzheimer\u2019s disease and mild cognitive impairment","volume":"115","author":"Vuurman","year":"2008","journal-title":"J. Neural Transm."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neurobiolaging.2009.01.002","article-title":"40-Hz steady state response in Alzheimer\u2019s disease and mild cognitive impairment","volume":"32","author":"Vuurman","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/sni.sni_342_17","article-title":"Deep brain stimulation for Alzheimer\u2019s Disease: An update","volume":"9","author":"Aldehri","year":"2018","journal-title":"Surg. Neurol. Int."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.clinph.2022.04.022","article-title":"Transcranial magnetic stimulation of the brain: What is stimulated?\u2014A consensus and critical position paper","volume":"140","author":"Siebner","year":"2022","journal-title":"Clin. Neurophysiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1016\/j.neuroimage.2012.03.035","article-title":"Measuring and manipulating brain connectivity with resting state functional connectivity magnetic resonance imaging (fcMRI) and transcranial magnetic stimulation (TMS)","volume":"62","author":"Fox","year":"2012","journal-title":"Neuroimage"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/ana.24695","article-title":"Long-term potentiation-like cortical plasticity is disrupted in Alzheimer\u2019s disease patients independently from age of onset","volume":"80","author":"Ponzo","year":"2016","journal-title":"Ann. Neurol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.clinph.2019.11.002","article-title":"Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014\u20132018)","volume":"131","author":"Lefaucheur","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1567-424X(09)70229-6","article-title":"Transcranial direct current stimulation (tDCS)","volume":"56","author":"Paulus","year":"2003","journal-title":"Suppl. Clin. Neurophysiol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Traikapi, A., and Konstantinou, N. (2021). Gamma Oscillations in Alzheimer\u2019s Disease and Their Potential Therapeutic Role. Front. Syst. Neurosci., 15.","DOI":"10.3389\/fnsys.2021.782399"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/ana.26444","article-title":"Decreased Frontal Gamma Activity in Alzheimer Disease Patients","volume":"92","author":"Casula","year":"2022","journal-title":"Ann. Neurol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"539621","DOI":"10.4061\/2011\/539621","article-title":"Slowing and Loss of Complexity in Alzheimer\u2019s EEG: Two Sides of the Same Coin?","volume":"2011","author":"Dauwels","year":"2011","journal-title":"Int. J. Alzheimer\u2019s Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1038\/s41593-023-01456-8","article-title":"Non-invasive temporal interference electrical stimulation of the human hippocampus","volume":"26","author":"Violante","year":"2023","journal-title":"Nat. Neurosci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1038\/s41593-023-01457-7","article-title":"Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning","volume":"26","author":"Wessel","year":"2023","journal-title":"Nat. Neurosci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1038\/s41562-024-01901-z","article-title":"Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills","volume":"8","author":"Vassiliadis","year":"2024","journal-title":"Nat. Hum. Behav."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Abijo, A., Lee, C.-Y., Huang, C.-Y., Ho, P.-C., and Tsai, K.-J. (2023). The Beneficial Role of Photobiomodulation in Neurodegenerative Diseases. Biomedicines, 11.","DOI":"10.3390\/biomedicines11071828"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s11357-024-01305-x","article-title":"Electrical brain networks before and after transcranial pulsed shockwave stimulation in Alzheimer\u2019s patients","volume":"47","author":"Wojtecki","year":"2025","journal-title":"GeroScience"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.brs.2022.05.002","article-title":"Human Studies of Transcranial Ultrasound neuromodulation: A systematic review of effectiveness and safety","volume":"15","author":"Sarica","year":"2022","journal-title":"Brain Stimul."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/373523a0","article-title":"Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein","volume":"373","author":"Games","year":"1995","journal-title":"Nature"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice","volume":"274","author":"HsiHsiao","year":"1996","journal-title":"Science"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"13287","DOI":"10.1073\/pnas.94.24.13287","article-title":"Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology","volume":"94","author":"Abramowski","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jnr.1247","article-title":"Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42)","volume":"66","author":"Rockenstein","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1523\/JNEUROSCI.20-11-04050.2000","article-title":"High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation","volume":"20","author":"Mucke","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"21562","DOI":"10.1074\/jbc.M100710200","article-title":"Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695","volume":"276","author":"Chishti","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nm0198-097","article-title":"Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes","volume":"4","author":"Holcomb","year":"1998","journal-title":"Nat. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0197-4580(01)00330-X","article-title":"FAD mutant PS-1 gene-targeted mice: Increased A beta 42 and A beta deposition without APP overproduction","volume":"23","author":"Flood","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: Potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3233\/JAD-132009","article-title":"Human ApoE \u03b54 alters circadian rhythm activity, IL-1\u03b2, and GFAP in CRND8 mice","volume":"43","author":"Graybeal","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1100\/tsw.2007.117","article-title":"The physiology of obese-hyperglycemic mice [ob\/ob mice]","volume":"7","year":"2007","journal-title":"Sci. World J."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00429-018-1779-x","article-title":"Chronic fornix deep brain stimulation in a transgenic Alzheimer\u2019s rat model reduces amyloid burden, inflammation, and neuronal loss","volume":"224","author":"Leplus","year":"2019","journal-title":"Brain Struct. Funct."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1038\/npp.2017.100","article-title":"Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer\u2019s Disease","volume":"42","author":"Xia","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.brs.2018.08.015","article-title":"The neuroprotective effect of deep brain stimulation at nucleus basalis of Meynert in transgenic mice with Alzheimer\u2019s disease","volume":"12","author":"Huang","year":"2019","journal-title":"Brain Stimul."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.exger.2013.05.001","article-title":"Low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) reverses A\u03b2(1-42)-mediated memory deficits in rats","volume":"48","author":"Tan","year":"2013","journal-title":"Exp. Gerontol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"105356","DOI":"10.1016\/j.neuint.2022.105356","article-title":"Repetitive transcranial magnetic stimulation (rTMS) for multiple neurological conditions in rodent animal models: A systematic review","volume":"157","author":"Zong","year":"2022","journal-title":"Neurochem. Int."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.brs.2021.01.012","article-title":"Cortical plasticity is correlated with cognitive improvement in Alzheimer\u2019s disease patients after rTMS treatment","volume":"14","author":"Li","year":"2021","journal-title":"Brain Stimul."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3233\/JAD-215361","article-title":"Repetitive Transcranial Magnetic Stimulation Improves Brain-Derived Neurotrophic Factor and Cholinergic Signaling in the 3xTgAD Mouse Model of Alzheimer\u2019s Disease","volume":"86","author":"McNerney","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"110735","DOI":"10.1016\/j.brainresbull.2023.110735","article-title":"The long-term effects of intermittent theta burst stimulation on Alzheimer\u2019s disease-type pathologies in APP\/PS1 mice","volume":"202","author":"Huang","year":"2023","journal-title":"Brain Res. Bull."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s40478-021-01198-3","article-title":"Repetitive transcranial magnetic stimulation increases the brain\u2019s drainage efficiency in a mouse model of Alzheimer\u2019s disease","volume":"9","author":"Lin","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Kim, W.-I., Han, J.-Y., Song, M.-K., Park, H.-K., and Jo, J. (2020). Cognitive Function Improvement in Mouse Model of Alzheimer\u2019s Disease Following Transcranial Direct Current Stimulation. Brain Sci., 10.","DOI":"10.3390\/brainsci10080547"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Podda, M.V., Cocco, S., Mastrodonato, A., Fusco, S., Leone, L., Barbati, S.A., Colussi, C., Ripoli, C., and Grassi, C. (2016). Anodal transcranial direct current stimulation boosts synaptic plasticity and memory in mice via epigenetic regulation of Bdnf expression. Sci. Rep., 6.","DOI":"10.1038\/srep22180"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Jeong, W.-H., Kim, W.-I., Lee, J.-W., Park, H.-K., Song, M.-K., Choi, I.-S., and Han, J.-Y. (2021). Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer\u2019s Disease. Brain Sci., 11.","DOI":"10.3390\/brainsci11111532"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.neuron.2019.04.011","article-title":"Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection","volume":"102","author":"Adaikkan","year":"2019","journal-title":"Neuron"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cell.2019.02.014","article-title":"Multi-sensory Gamma Stimulation Ameliorates Alzheimer\u2019s-Associated Pathology and Improves Cognition","volume":"177","author":"Martorell","year":"2019","journal-title":"Cell"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/alzrt232","article-title":"Photobiomodulation with near infrared light mitigates Alzheimer\u2019s disease-related pathology in cerebral cortex\u2014Evidence from two transgenic mouse models","volume":"6","author":"Purushothuman","year":"2014","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3233\/JAD-191210","article-title":"Photobiomodulation for Alzheimer\u2019s Disease: Translating Basic Research to Clinical Application","volume":"75","author":"Enengl","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40035-021-00274-x","article-title":"Effects of transcranial ultrasound stimulation pulsed at 40 Hz on A\u03b2 plaques and brain rhythms in 5\u00d7FAD mice","volume":"10","author":"Park","year":"2021","journal-title":"Transl. Neurodegener."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1016\/j.neurobiolaging.2015.04.016","article-title":"Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer\u2019s disease: A systematic review and meta-analysis","volume":"36","author":"Hsu","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1136\/jnnp.2009.197848","article-title":"Improved language performance in Alzheimer disease following brain stimulation","volume":"82","author":"Cotelli","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1001\/archneur.63.11.1602","article-title":"Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease","volume":"63","author":"Cotelli","year":"2006","journal-title":"Arch. Neurol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/j.1468-1331.2008.02202.x","article-title":"Transcranial magnetic stimulation improves naming in Alzheimer disease patients at different stages of cognitive decline","volume":"15","author":"Cotelli","year":"2008","journal-title":"Eur. J. Neurol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00702-010-0578-1","article-title":"Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer\u2019s disease: A proof of concept study","volume":"118","author":"Bentwich","year":"2011","journal-title":"J. Neural Transm."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00415-011-6128-4","article-title":"Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer\u2019s dementia","volume":"259","author":"Ahmed","year":"2012","journal-title":"J. Neurol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00702-012-0902-z","article-title":"Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer\u2019s disease: A randomized, double-blind study","volume":"120","author":"Rabey","year":"2013","journal-title":"J. Neural Transm."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/1533317513517047","article-title":"Open-label, short-term, repetitive transcranial magnetic stimulation in patients with Alzheimer\u2019s disease with functional imaging correlates and literature review","volume":"29","author":"Devi","year":"2014","journal-title":"Am. J. Alzheimer\u2019s Dis. Other Dement."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4137\/JEN.S24004","article-title":"Short and Long-term Effects of rTMS Treatment on Alzheimer\u2019s Disease at Different Stages: A Pilot Study","volume":"9","author":"Rutherford","year":"2015","journal-title":"J. Exp. Neurosci."},{"key":"ref_195","first-page":"280","article-title":"Adjunctive treatment with high frequency repetitive transcranial magnetic stimulation for the behavioral and psychological symptoms of patients with Alzheimer\u2019s disease: A randomized, double-blind, sham-controlled study","volume":"27","author":"Wu","year":"2015","journal-title":"Shanghai Arch. Psychiatry"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3988\/jcn.2016.12.1.57","article-title":"Treatment of Alzheimer\u2019s Disease with Repetitive Transcranial Magnetic Stimulation Combined with Cognitive Training: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study","volume":"12","author":"Lee","year":"2016","journal-title":"J. Clin. Neurol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.brs.2017.12.011","article-title":"Similar clinical improvement and maintenance after rTMS at 5 Hz using a simple vs. complex protocol in Alzheimer\u2019s disease","volume":"11","year":"2018","journal-title":"Brain Stimul."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00702-019-02022-y","article-title":"High-frequency repetitive transcranial magnetic stimulation combined with cognitive training improves cognitive function and cortical metabolic ratios in Alzheimer\u2019s disease","volume":"126","author":"Zhang","year":"2019","journal-title":"J. Neural Transm."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3233\/JAD-190888","article-title":"Low-Frequency Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex Enhances Recognition Memory in Alzheimer\u2019s Disease","volume":"72","author":"Turriziani","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.3233\/JAD-200640","article-title":"Neuromodulation for Apathy in Alzheimer\u2019s Disease: A Double-Blind, Randomized, Sham-Controlled Pilot Study","volume":"77","author":"Padala","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_201","first-page":"1655","article-title":"Enhancing cognitive training effects in Alzheimer\u2019s disease: rTMS as an add-on treatment","volume":"13","author":"Bagattini","year":"2020","journal-title":"Brain Stimul. Basic Transl. Clin. Res. Neuromodul."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.brs.2019.12.020","article-title":"Strengthened theta-burst transcranial magnetic stimulation as an adjunctive treatment for Alzheimer\u2019s disease: An open-label pilot study","volume":"13","author":"Wu","year":"2020","journal-title":"Brain Stimul."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Brem, A.-K., Di Iorio, R., Fried, P.J., Oliveira-Maia, A.J., Marra, C., Profice, P., Quaranta, D., Schilberg, L., Atkinson, N.J., and Seligson, E.E. (2020). Corticomotor Plasticity Predicts Clinical Efficacy of Combined Neuromodulation and Cognitive Training in Alzheimer\u2019s Disease. Front. Aging Neurosci., 12.","DOI":"10.3389\/fnagi.2020.00200"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jalz.2019.08.197","article-title":"Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer\u2019s disease","volume":"16","author":"Sabbagh","year":"2020","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"136337","DOI":"10.1016\/j.neulet.2021.136337","article-title":"Transcranial magnetic stimulation for sleep disorders in Alzheimer\u2019s disease: A double-blind, randomized, and sham-controlled pilot study","volume":"766","author":"Zhou","year":"2022","journal-title":"Neurosci. Lett."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Mayer, J.T., Masse, C., Chopard, G., Nicolier, M., Bereau, M., Magnin, E., Monnin, J., Tio, G., Haffen, E., and Vandel, P. (2021). Repetitive Transcranial Magnetic Stimulation as an Add-On Treatment for Cognitive Impairment in Alzheimer\u2019s Disease and Its Impact on Self-Rated Quality of Life and Caregiver\u2019s Burden. Brain Sci., 11.","DOI":"10.3390\/brainsci11060740"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.brs.2021.11.007","article-title":"Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer\u2019s disease: A randomized controlled trial","volume":"15","author":"Wu","year":"2022","journal-title":"Brain Stimul."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11357-021-00508-w","article-title":"Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer\u2019s patients: An EEG graph study","volume":"44","author":"Vecchio","year":"2022","journal-title":"Geroscience"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1177\/19714009211067409","article-title":"Effects of repetitive transcranial magnetic stimulation combined with cognitive training on resting-state brain activity in Alzheimer\u2019s disease","volume":"35","author":"Qin","year":"2022","journal-title":"Neuroradiol. J."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.clinph.2022.02.017","article-title":"Multi-site rTMS with cognitive training improves apathy in the long term in Alzheimer\u2019s disease: A 4-year chart review","volume":"137","author":"Moreno","year":"2022","journal-title":"Clin. Neurophysiol."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Mimenza-Alvarado, A.J., Aguilar-Navarro, S.G., Martinez-Carrillo, F.M., R\u00edos-Ponce, A.E., and Villafuerte, G. (2021). Use of Fast Gamma Magnetic Stimulation Over the Left Prefrontal Dorsolateral Cortex for the Treatment of MCI and Mild Alzheimer\u2019s Disease: A Double-Blind, Randomized, Sham-Controlled, Pilot Study. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.729872"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"33864","DOI":"10.18632\/oncotarget.13060","article-title":"Repetitive transcranial magnetic stimulation improves cognitive function of Alzheimer\u2019s disease patients","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Jia, Y., Xu, L., Yang, K., Zhang, Y., Lv, X., Zhu, Z., Chen, Z., Zhu, Y., Wei, L., and Li, X. (2021). Precision Repetitive Transcranial Magnetic Stimulation Over the Left Parietal Cortex Improves Memory in Alzheimer\u2019s Disease: A Randomized, Double-Blind, Sham-Controlled Study. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.693611"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"114721","DOI":"10.1016\/j.psychres.2022.114721","article-title":"Parietal-hippocampal rTMS improves cognitive function in Alzheimer\u2019s disease and increases dynamic functional connectivity of default mode network","volume":"315","author":"Wei","year":"2022","journal-title":"Psychiatry Res."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.neuroimage.2017.12.048","article-title":"Transcranial magnetic stimulation of the precuneus enhances memory and neural activity in prodromal Alzheimer\u2019s disease","volume":"169","author":"Koch","year":"2018","journal-title":"Neuroimage"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1093\/brain\/awac285","article-title":"Precuneus magnetic stimulation for Alzheimer\u2019s disease: A randomized, sham-controlled trial","volume":"145","author":"Koch","year":"2022","journal-title":"Brain"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3233\/JAD-150067","article-title":"Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer\u2019s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation","volume":"48","author":"Anderkova","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jns.2014.08.036","article-title":"Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer\u2019s disease: A pilot study","volume":"346","author":"Eliasova","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Leocani, L., Dalla Costa, G., Coppi, E., Santangelo, R., Pisa, M., Ferrari, L., Bernasconi, M.P., Falautano, M., Zangen, A., and Magnani, G. (2020). Repetitive Transcranial Magnetic Stimulation with H-Coil in Alzheimer\u2019s Disease: A Double-Blind, Placebo-Controlled Pilot Study. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.614351"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.brs.2022.06.004","article-title":"Effect of cerebellum stimulation on cognitive recovery in patients with Alzheimer disease: A randomized clinical trial","volume":"15","author":"Yao","year":"2022","journal-title":"Brain Stimul."},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Cotelli, M., Manenti, R., Brambilla, M., Petesi, M., Rosini, S., Ferrari, C., Zanetti, O., and Miniussi, C. (2014). Anodal tDCS during face-name associations memory training in Alzheimer\u2019s patients. Front. Aging Neurosci., 6.","DOI":"10.3389\/fnagi.2014.00038"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Khedr, E.M., El Gamal, N.F., El-Fetoh, N.A., Khalifa, H., Ahmed, E.M., Ali, A.M., Noaman, M., El-Baki, A.A., and Karim, A.A. (2014). A Double-Blind Randomized Clinical Trial on the Efficacy of Cortical Direct Current Stimulation for the Treatment of Alzheimer\u2019s Disease. Front. Aging Neurosci., 6.","DOI":"10.3389\/fnagi.2014.00275"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.brs.2013.10.003","article-title":"Effects of a non-focal plasticity protocol on apathy in moderate Alzheimer\u2019s disease: A randomized, double-blind, sham-controlled trial","volume":"7","author":"Suemoto","year":"2014","journal-title":"Brain Stimul."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.brs.2019.06.003","article-title":"Effects of 6-month at-home transcranial direct current stimulation on cognition and cerebral glucose metabolism in Alzheimer\u2019s disease","volume":"12","author":"Im","year":"2019","journal-title":"Brain Stimul."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.clinph.2019.08.016","article-title":"Behavioural and electrophysiological modulations induced by transcranial direct current stimulation in healthy elderly and Alzheimer\u2019s disease patients: A pilot study","volume":"130","author":"Rodella","year":"2019","journal-title":"Clin. Neurophysiol."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Inagawa, T., Yokoi, Y., Narita, Z., Maruo, K., Okazaki, M., and Nakagome, K. (2019). Safety and Feasibility of Transcranial Direct Current Stimulation for Cognitive Rehabilitation in Patients with Mild or Major Neurocognitive Disorders: A Randomized Sham-Controlled Pilot Study. Front. Hum. Neurosci., 13.","DOI":"10.3389\/fnhum.2019.00273"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3233\/JAD-210378","article-title":"High-Definition Transcranial Direct Current Stimulation Improves Delayed Memory in Alzheimer\u2019s Disease Patients: A Pilot Study Using Computational Modeling to Optimize Electrode Position","volume":"83","author":"Rasmussen","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3233\/JAD-210003","article-title":"Verbal Fluency in Mild Alzheimer\u2019s Disease: Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex","volume":"81","author":"Smirni","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neucli.2022.02.003","article-title":"Effects of multisite anodal transcranial direct current stimulation combined with cognitive stimulation in patients with Alzheimer\u2019s disease and its neurophysiological correlates: A double-blind randomized clinical trial","volume":"52","author":"Andrade","year":"2022","journal-title":"Neurophysiol. Clin."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.trci.2017.03.003","article-title":"Inferior parietal transcranial direct current stimulation with training improves cognition in anomic Alzheimer\u2019s disease and frontotemporal dementia","volume":"3","author":"Roncero","year":"2017","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/1545968319840285","article-title":"Therapeutic Role of Transcranial Direct Current Stimulation in Alzheimer Disease Patients: Double-Blind, Placebo-Controlled Clinical Trial","volume":"33","author":"Khedr","year":"2019","journal-title":"Neurorehabilit. Neural Repair"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/YCT.0000000000000639","article-title":"A Pilot Study Comparing Effects of Bifrontal Versus Bitemporal Transcranial Direct Current Stimulation in Mild Cognitive Impairment and Mild Alzheimer Disease","volume":"36","author":"Liu","year":"2020","journal-title":"J. ECT"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s40520-020-01546-8","article-title":"Effects of short- and long-term neurostimulation (tDCS) on Alzheimer\u2019s disease patients: Two randomized studies","volume":"33","author":"Gangemi","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1212\/01.wnl.0000317060.43722.a3","article-title":"Transcranial direct current stimulation improves recognition memory in Alzheimer disease","volume":"71","author":"Ferrucci","year":"2008","journal-title":"Neurology"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/jnnp.2007.141853","article-title":"Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease","volume":"80","author":"Boggio","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.brs.2011.06.006","article-title":"Prolonged visual memory enhancement after direct current stimulation in Alzheimer\u2019s disease","volume":"5","author":"Boggio","year":"2012","journal-title":"Brain Stimul."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13195-016-0180-3","article-title":"Transcranial direct current stimulation as a memory enhancer in patients with Alzheimer\u2019s disease: A randomized, placebo-controlled trial","volume":"8","author":"Bystad","year":"2016","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.brs.2022.11.009","article-title":"Efficacy and safety of simultaneous rTMS-tDCS over bilateral angular gyrus on neuropsychiatric symptoms in patients with moderate Alzheimer\u2019s disease: A prospective, randomized, sham-controlled pilot study","volume":"15","author":"Hu","year":"2022","journal-title":"Brain Stimul."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Br\u00e9chet, L., Yu, W., Biagi, M.C., Ruffini, G., Gagnon, M., Manor, B., and Pascual-Leone, A. (2021). Patient-Tailored, Home-Based Non-invasive Brain Stimulation for Memory Deficits in Dementia Due to Alzheimer\u2019s Disease. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.598135"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3233\/JAD-215072","article-title":"Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer\u2019s Disease: A Case Series","volume":"85","author":"Dhaynaut","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Kehler, L., Francisco, C.O., Uehara, M.A., and Moussavi, Z. (2020, January 20\u201324). The effect of transcranial alternating current stimulation (tACS) on cognitive function in older adults with dementia. Proceedings of the 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada.","DOI":"10.1109\/EMBC44109.2020.9175903"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.brs.2021.03.007","article-title":"Exposure to gamma tACS in Alzheimer\u2019s disease: A randomized, double-blind, sham-controlled, crossover, pilot study","volume":"14","author":"Benussi","year":"2021","journal-title":"Brain Stimul."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/ana.26411","article-title":"Increasing Brain Gamma Activity Improves Episodic Memory and Restores Cholinergic Dysfunction in Alzheimer\u2019s Disease","volume":"92","author":"Benussi","year":"2022","journal-title":"Ann. Neurol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13195-021-00922-4","article-title":"Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer\u2019s disease","volume":"13","author":"Sprugnoli","year":"2021","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3233\/JAD-160081","article-title":"Short-Term Effects of Rhythmic Sensory Stimulation in Alzheimer\u2019s Disease: An Exploratory Pilot Study","volume":"52","author":"Ahonen","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Chan, D., Suk, H.-J., Jackson, B.L., Milman, N.P., Stark, D., Klerman, E.B., Kitchener, E., Avalos, V.S.F., de Weck, G., and Banerjee, A. (2022). Gamma frequency sensory stimulation in mild probable Alzheimer\u2019s dementia patients: Results of feasibility and pilot studies. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0278412"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Cimenser, A., Hempel, E., Travers, T., Strozewski, N., Martin, K., Malchano, Z., and Haj\u00f3s, M. (2021). Sensory-Evoked 40-Hz Gamma Oscillation Improves Sleep and Daily Living Activities in Alzheimer\u2019s Disease Patients. Front. Syst. Neurosci., 15.","DOI":"10.3389\/fnsys.2021.746859"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"e12178","DOI":"10.1002\/trc2.12178","article-title":"A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer\u2019s disease","volume":"7","author":"He","year":"2021","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_249","first-page":"6852303","article-title":"The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer\u2019s Disease","volume":"2018","author":"Ismail","year":"2018","journal-title":"Int. J. Alzheimer\u2019s Dis."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3233\/JAD-220467","article-title":"A Randomized, Double-Blind, and Sham-Controlled Trial of an Innovative Brain-Gut Photobiomodulation Therapy: Safety and Patient Compliance","volume":"90","author":"Blivet","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1002\/acn3.51882","article-title":"Transcranial pulse stimulation in the treatment of mild neurocognitive disorders","volume":"10","author":"Fong","year":"2023","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"e2459170","DOI":"10.1001\/jamanetworkopen.2024.59170","article-title":"Ultrasound Neuromodulation with Transcranial Pulse Stimulation in Alzheimer Disease: A Randomized Clinical Trial","volume":"8","author":"Matt","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_253","first-page":"216","article-title":"Stimulation of the basal nucleus of Meynert in senile dementia of Alzheimer\u2019s type. A preliminary report","volume":"48","author":"Turnbull","year":"1985","journal-title":"Appl. Neurophysiol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ana.22089","article-title":"A phase I trial of deep brain stimulation of memory circuits in Alzheimer\u2019s disease","volume":"68","author":"Laxton","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3233\/JAD-121579","article-title":"Symptomatic treatment of memory decline in Alzheimer\u2019s disease by deep brain stimulation: A feasibility study","volume":"34","author":"Fontaine","year":"2013","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.brs.2014.11.020","article-title":"Deep Brain Stimulation Influences Brain Structure in Alzheimer\u2019s Disease","volume":"8","author":"Sankar","year":"2015","journal-title":"Brain Stimul."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/mp.2014.32","article-title":"Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer\u2019s dementia","volume":"20","author":"Kuhn","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.brs.2015.04.002","article-title":"Deep Brain Stimulation of the Nucleus Basalis of Meynert in Early Stage of Alzheimer\u2019s Dementia","volume":"8","author":"Kuhn","year":"2015","journal-title":"Brain Stimul."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.brs.2016.05.013","article-title":"Deep Brain Stimulation of the Nucleus Basalis of Meynert in Alzheimer\u2019s Dementia: Potential Predictors of Cognitive Change and Results of a Long-Term Follow-Up in Eight Patients","volume":"9","author":"Hardenacke","year":"2016","journal-title":"Brain Stimul."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3233\/JAD-160017","article-title":"A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer\u2019s Disease","volume":"54","author":"Lozano","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/WAD.0000000000000095","article-title":"Bilateral Cortical Encephalomalacia in a Patient Implanted with Bilateral Deep Brain Stimulation for Alzheimer\u2019s Disease: A Case Report","volume":"30","author":"McMullen","year":"2016","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3171\/2015.6.JNS15716","article-title":"Bilateral deep brain stimulation of the fornix for Alzheimer\u2019s disease: Surgical safety in the ADvance trial","volume":"125","author":"Ponce","year":"2016","journal-title":"J. Neurosurg."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/ejn.13749","article-title":"Deep brain stimulation of the nucleus basalis of Meynert attenuates early EEG components associated with defective sensory gating in patients with Alzheimer disease\u2014A two-case study","volume":"51","author":"Reichert","year":"2020","journal-title":"Eur. J. Neurosci."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/ner.12626","article-title":"Neuroanatomical Characteristics Associated with Response to Deep Brain Stimulation of the Nucleus Basalis of Meynert for Alzheimer\u2019s Disease","volume":"21","author":"Baldermann","year":"2018","journal-title":"Neuromodulation"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3233\/JAD-180121","article-title":"Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed Activation","volume":"64","author":"Leoutsakos","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3233\/JAD-170082","article-title":"Deep Brain Stimulation of Frontal Lobe Networks to Treat Alzheimer\u2019s Disease","volume":"62","author":"Scharre","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.4103\/1673-5374.241468","article-title":"Partial improvement in performance of patients with severe Alzheimer\u2019s disease at an early stage of fornix deep brain stimulation","volume":"13","author":"Mao","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1093\/cercor\/bhab371","article-title":"Modulating Gamma Oscillations Promotes Brain Connectivity to Improve Cognitive Impairment","volume":"32","author":"Liu","year":"2022","journal-title":"Cereb. Cortex"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1440-1819.2004.01265.x","article-title":"Improvement in behavioral symptoms and advance of activity acrophase after short-term bright light treatment in severe dementia","volume":"58","author":"Skjerve","year":"2004","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.buildenv.2008.02.005","article-title":"Ambient bright light in dementia: Effects on behaviour and circadian rhythmicity","volume":"44","author":"Aarts","year":"2009","journal-title":"Build. Environ."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1017\/S1041610209008886","article-title":"Bright light therapy for agitation in dementia: A randomized controlled trial","volume":"21","author":"Burns","year":"2009","journal-title":"Int. Psychogeriatr."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"e041146","DOI":"10.1002\/alz.041146","article-title":"Sensory gamma frequency stimulation in cognitively healthy and AD individuals safely induces highly coordinated 40 hz neural oscillation: A preliminary study of non-invasive sensory stimulation for treating Alzheimer\u2019s disease","volume":"16","author":"Suk","year":"2020","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1016\/j.clinph.2017.09.007","article-title":"Plasticity induced by non-invasive transcranial brain stimulation: A position paper","volume":"128","author":"Huang","year":"2017","journal-title":"Clin. Neurophysiol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cnp.2022.05.002","article-title":"Non-invasive brain stimulation and neuroenhancement","volume":"7","author":"Antal","year":"2022","journal-title":"Clin. Neurophysiol. Pract."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.clinph.2022.09.010","article-title":"Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer\u2019s disease? An updated meta-analysis","volume":"144","author":"Kent","year":"2022","journal-title":"Clin. Neurophysiol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.clinph.2016.10.087","article-title":"Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)","volume":"128","author":"Lefaucheur","year":"2017","journal-title":"Clin. Neurophysiol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.brs.2016.06.004","article-title":"Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016","volume":"9","author":"Bikson","year":"2016","journal-title":"Brain Stimul."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"1902583","DOI":"10.1002\/advs.201902583","article-title":"Transcranial Pulse Stimulation with Ultrasound in Alzheimer\u2019s Disease\u2014A New Navigated Focal Brain Therapy","volume":"7","author":"Beisteiner","year":"2020","journal-title":"Adv. Sci."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"410","DOI":"10.14283\/jpad.2022.40","article-title":"Effects of Non-Invasive Brain Stimulation on Alzheimer\u2019s Disease","volume":"9","author":"Gu","year":"2022","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.neuropharm.2012.07.002","article-title":"Non-pharmacological cognitive enhancement","volume":"64","author":"Dresler","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/acschemneuro.8b00571","article-title":"Hacking the Brain: Dimensions of Cognitive Enhancement","volume":"10","author":"Dresler","year":"2018","journal-title":"ACS Chem. Neurosci."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/3\/547\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:57:16Z","timestamp":1760029036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/3\/547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":281,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["medicina61030547"],"URL":"https:\/\/doi.org\/10.3390\/medicina61030547","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,20]]}}}