{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:53:54Z","timestamp":1783022034186,"version":"3.54.6"},"reference-count":78,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201dDunarea de Jos\u201d University of Galati"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Psoriasis is a chronic inflammatory skin disease, and biologic therapies have revolutionized treatment by targeting key cytokine pathways. While these therapies effectively control psoriatic lesions, their impact on other cutaneous structures, such as cherry angiomas and solar lentigines, remains unclear. Angiomas are benign vascular proliferations influenced by systemic inflammation and hormonal factors, whereas solar lentigines are UV-induced pigmentary lesions associated with aging and sun exposure. This study aimed to assess the impact of biologic therapies on the development of these lesions in psoriasis patients. Materials and Methods: This retrospective observational study was conducted over a five-year period (2019\u20132024) at a tertiary dermatological center in Southeastern Europe. Clinical and demographic data, including treatment history, were extracted from medical records, while digital dermoscopy was used to assess lesion progression. Statistical analyses evaluated associations among biologic therapy classes, systemic inflammation, and cutaneous lesion development. Results: Angioma prevalence was significantly higher among postmenopausal women and those with osteoporosis, suggesting a hormonal influence on vascular proliferation. Patients with psoriatic arthritis had a greater angioma burden, reinforcing the role of chronic inflammation in angiogenesis. IL-23 inhibitors were linked to increased angioma formation compared to TNF-\u03b1 inhibitors, while methotrexate and UVB therapy appeared to have a protective effect. Solar lentigines were more frequent in postmenopausal women and in patients with systemic inflammatory conditions. In contrast, smoking and moderate alcohol consumption were associated with lower lesion counts. Conclusions: Our findings suggest that biologic therapies, particularly IL-23 inhibitors, may contribute to angiogenesis and pigmentary changes in psoriasis patients, highlighting the influence of systemic inflammation on vascular and melanocytic activity. Additionally, TNF-\u03b1 inhibitors and NSAIDs were associated with an increased prevalence of solar lentigines, while methotrexate and UVB therapy appeared to have a protective effect. Given these associations, further research is needed to elucidate the underlying mechanisms and refine treatment strategies to optimize dermatologic care for psoriasis patients.<\/jats:p>","DOI":"10.3390\/medicina61040565","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T13:48:20Z","timestamp":1742824100000},"page":"565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cutaneous Changes Beyond Psoriasis: The Impact of Biologic Therapies on Angiomas and Solar Lentigines"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3029-9245","authenticated-orcid":false,"given":"Florin Ciprian","family":"Bujoreanu","sequence":"first","affiliation":[{"name":"Department of Dermatology, \u201cSaint Parascheva\u201d Infectious Disease Clinical Hospital, 800179 Galati, Romania"},{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Sabina","family":"Radaschin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \u201cSaint Parascheva\u201d Infectious Disease Clinical Hospital, 800179 Galati, Romania"},{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fulga","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bujoreanu Bezman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Tiutiuca","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Cr\u0103escu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Panti\u0219","sequence":"additional","affiliation":[{"name":"Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 1 University Street, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9249-5247","authenticated-orcid":false,"given":"Elena","family":"Niculet","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-7284","authenticated-orcid":false,"given":"Alina","family":"Ple\u0219ea Condratovici","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-7068","authenticated-orcid":false,"given":"Alin Lauren\u021biu","family":"Tatu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \u201cSaint Parascheva\u201d Infectious Disease Clinical Hospital, 800179 Galati, Romania"},{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Yatsuzuka, K., Muto, J., Shiraishi, K., Murakami, M., and Fujisawa, Y. 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