{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T13:26:19Z","timestamp":1794317179331,"version":"4.9.0"},"reference-count":31,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Total hip replacement and total knee arthroplasty carry a high risk of postoperative venous thromboembolism (VTE); therefore, anticoagulation prophylaxis is recommended in these patients. Unfortunately, there are no guidelines about VTE prophylaxis in patients with hemophilia who underwent these high-risk surgeries. To determine whether these patients have a high risk of VTE, we conducted a retrospective study on patients with hemophilia who underwent elective arthroplasty at our hospital in 2016. Materials and Methods: There were 11 patients with hemophilia A and B who underwent high-risk surgeries. Recombinant factor VIII or IX and also active recombinant Factor VII were used for perioperative hemostasis, and LMWH was administered for thromboembolic prophylaxis. Postoperatively, we collected information on the duration of factor VIII\/IX infusion, VTE-prophylaxis, and complications. Results: Postoperative bleeding was minimal in most cases, with an average blood loss of 500 mL. No major thrombotic events were reported, and the need for transfusion was low, with only one patient requiring additional blood products. The VTE prophylaxis included prophylactic enoxaparin and hemostatic treatment. At the 1-year follow-up, we did not find any evidence of clinical VTE in our patients. Conclusions: Better risk stratification is needed to identify patients who would benefit from pharmacological prophylaxis. Total arthroplasty in hemophilic patients is feasible and safe when managed by a multidisciplinary team and supported by tailored antithrombotic prophylaxis protocols. The use of recombinant coagulation factors and LMWH ensures effective bleeding control and thromboembolic prevention, enhancing patient outcomes. These findings underscore the importance of individualized care in this high-risk population.<\/jats:p>","DOI":"10.3390\/medicina61040570","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T13:48:20Z","timestamp":1742824100000},"page":"570","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Venous Thromboembolism Prophylaxis in Hemophilic Patients Undergoing Total Hip or Knee Arthroplasty: Insights from a Single-Center Experience"],"prefix":"10.3390","volume":"61","author":[{"given":"Oana-Viola","family":"Badulescu","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-0649","authenticated-orcid":false,"given":"Paul-Dan","family":"Sirbu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-2175","authenticated-orcid":false,"given":"Manuela","family":"Ciocoiu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Vladeanu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-7761","authenticated-orcid":false,"given":"Carmen Elena","family":"Plesoianu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Bojan","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Medicine and Pharmacy Grigore T. Popa, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Iliescu-Halitchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2881-3527","authenticated-orcid":false,"given":"Razvan","family":"Tudor","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Huzum","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihnea-Theodor","family":"Sirbu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5637-2095","authenticated-orcid":false,"given":"Norin","family":"Forna","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheorghe","family":"Sofron","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Friedl","sequence":"additional","affiliation":[{"name":"Department of Othopedics and Traumatology, Wertheim Hospital, 97877 Wertheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Bararu-Bojan","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2345883","DOI":"10.1001\/jamanetworkopen.2023.45883","article-title":"Venous Thromboembolism in Total Hip and Total Knee Arthroplasty","volume":"6","author":"Simon","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/1076029614543139","article-title":"Thromboprophylaxis and Incidence of Venous Thromboembolism in Patients with Hemophilia A or B Who Underwent High-Risk Orthopedic Surgeries","volume":"22","author":"Raza","year":"2016","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12959-024-00633-4","article-title":"Utilization of the Caprini risk assessment model(RAM) to predict venous thromboembolism after primary hip and knee arthroplasty: An analysis of the Healthcare Cost and Utilization Project(HCUP)","volume":"22","author":"Lin","year":"2024","journal-title":"Thromb. J."},{"key":"ref_4","unstructured":"Krause, M., Von Auer Ch Kurth, A., Bohm, M., Hovy, L., and Scharrer, I. (2005, January 1\u20134). Evaluation of thrombotic events in hemophiliacs undergoing major orthopedic surgery without thrombosis prophylaxis. Proceedings of the 36th Hemophilia Symposium, Hamburg, Germany."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.thromres.2020.12.007","article-title":"Thromboprophylaxis for orthopedic surgery; An updated meta-analysis","volume":"199","author":"Haykal","year":"2021","journal-title":"Thromb. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/EJA.0000000000000725","article-title":"European guidelines on perioperative venous thromboembolism prophylaxis: Patients with preexisting coagulation disorders and after severe perioperative bleeding","volume":"35","author":"Ahmed","year":"2018","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1111\/bcp.14838","article-title":"Haemophilia, state of the art and new therapeutic opportunities, a regulatory perspective","volume":"87","author":"Tomeo","year":"2021","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.blre.2013.06.002","article-title":"Hemophilia A in the third millennium","volume":"27","author":"Franchini","year":"2013","journal-title":"Blood Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.thromres.2012.08.265","article-title":"Surgery in patients with hemophilia: Is thromboprophylaxis mandatory?","volume":"130","author":"Ozelo","year":"2012","journal-title":"Thromb. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/hae.13301","article-title":"PERSEPT 1: A phase 3 trial of activated eptacog beta for on-demand treatment of haemophilia inhibitor-related bleeding","volume":"23","author":"Wang","year":"2017","journal-title":"Haemophilia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.4103\/jfmpc.jfmpc_603_19","article-title":"Attenuation of phenotypical expression of severe hemophilia A in presence of simultaneous prothrombotic Factor V mutation: The debate continues","volume":"8","author":"Acharyya","year":"2019","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1055\/s-0038-1649922","article-title":"Low prevalence of the factor V Leiden mutation among \u201csevere\u201d hemophiliacs with a \u201cmilder\u201d bleeding diathesis","volume":"74","author":"Arbini","year":"1995","journal-title":"Thromb. Haemost."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1056\/NEJMoa1708483","article-title":"AAV5-Factor VIII Gene Transfer in Severe Hemophilia A","volume":"377","author":"Rangarajan","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_14","first-page":"7290945","article-title":"Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature","volume":"2017","author":"Darawshy","year":"2017","journal-title":"Case Rep. Hematol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1007\/PL00014351","article-title":"Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding\u2014Successful thrombolysis under heparin therapy","volume":"158","author":"Ettingshausen","year":"1999","journal-title":"Eur. J. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"102228","DOI":"10.1016\/j.rpth.2023.102228","article-title":"Inhibitors in hemophilia: Association with surgery plans and outcomes in a retrospective cohort study","volume":"7","author":"Olasupo","year":"2023","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2516.2006.01183.x","article-title":"Fatal postoperative pulmonary embolism in mild haemophilia","volume":"12","author":"Butcher","year":"2006","journal-title":"Haemophilia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/hae.14161","article-title":"Low rate of subclinical venous thrombosis in patients with haemophilia undergoing major orthopaedic surgery in the absence of pharmacological thromboprophylaxis","volume":"26","author":"Verstraete","year":"2020","journal-title":"Haemophilia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1111\/jth.14296","article-title":"The future of bypassing agents for hemophilia with inhibitors in the era of novel agents","volume":"16","author":"Shapiro","year":"2018","journal-title":"J. Thromb. Haemost."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1365-2516.2000.00431.x","article-title":"Venous thromboembolism after hip fracture surgery in a patient with haemophilia B and factor V Arg506Gln (factor V Leiden)","volume":"6","author":"Pruthi","year":"2000","journal-title":"Haemophilia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1182\/blood.2021014810","article-title":"Recombinant von Willebrand factor prophylaxis in patients with severe von Willebrand disease: Phase 3 study results","volume":"140","author":"Leebeek","year":"2022","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/j.1365-2516.2009.02084.x","article-title":"Venous thrombosis prophylaxis in haemophilics undergoing major orthopaedic surgery: A survey of haemophilia treatment centres","volume":"15","author":"Pradhan","year":"2009","journal-title":"Haemophilia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1182\/blood-2009-07-215665","article-title":"How I treat age-related morbidities in elderly persons with hemophilia","volume":"114","author":"Mannucci","year":"2009","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/MBC.0000000000000064","article-title":"Thromboprophylaxis in haemophilia patients undergoing orthopaedic surgery","volume":"25","year":"2014","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"746","DOI":"10.2106\/JBJS.9408.ebo746","article-title":"American Academy of Orthopaedic Surgeons. Preventing Venous Thromboembolic Disease in Patients Undergoing Elective Hip and Knee Arthroplasty. Evidence-Based Guidelines and Evidence Report","volume":"94","author":"Jacobs","year":"2012","journal-title":"J. Bone Jt. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1055\/s-0037-1613227","article-title":"Venous thrombosis following the use of intermediate purity FVIII concentrate to treat patients with von Willebrand\u2019s disease","volume":"88","author":"Makris","year":"2002","journal-title":"Thromb. Haemost."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJM200008173430702","article-title":"High plasma levels of factor VIII and the risk of recurrent venous thromboembolism","volume":"343","author":"Kyrle","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1111\/jth.15444","article-title":"Hemophilic arthropathy: Current knowledge and future perspectives","volume":"19","author":"Gualtierotti","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/hae.15012","article-title":"Is pharmacological thromboprophylaxis necessary in persons with haemophilia undergoing major orthopaedic surgery?","volume":"30","author":"Linari","year":"2024","journal-title":"Haemophilia"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Badulescu, O.V., Bararu Bojan, I., Badescu, M.C., Filip, N., Chels\u0103u, A., Ciocoiu, M., Vladeanu, M., Filip, A., Forna, N., and Sirbu, M.T. (2023). Thromboembolic Disease in Haemophilic Patients Undergoing Major Orthopaedic Surgery: Is Thromboprophylaxis Mandatory?. Diagnostics, 13.","DOI":"10.3390\/diagnostics13010013"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/MBC.0000000000000179","article-title":"Venous thrombosis in von Willebrand disease as observed in one centre and as reported in the literature","volume":"26","author":"Girolami","year":"2015","journal-title":"Blood Coagul. Fibrinolysis"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/570\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:58:39Z","timestamp":1760029119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,22]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["medicina61040570"],"URL":"https:\/\/doi.org\/10.3390\/medicina61040570","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,22]]}}}