{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:23:14Z","timestamp":1783984994060,"version":"3.55.0"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: This study examined the prevalence and risk factors of dynapenia, pre-sarcopenia, and sarcopenia among Korean adults using nationally representative data. Materials and Methods: A cross-sectional analysis was conducted using the 2022\u20132023 Korea National Health and Nutrition Examination Survey (KNHANES). Participants aged 20 years and older with available muscle strength and body composition measurements were included. Handgrip strength and skeletal muscle mass (measured via bioelectrical impedance analysis) were used to classify participants based on the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Logistic regression analysis identified associated risk factors. Results: The prevalence of pre-sarcopenia, dynapenia, and sarcopenia was 9.6%, 3.4%, and 1.6%, respectively. Pre-sarcopenia was most common across all age groups, while sarcopenia was primarily observed in older adults (p &lt; 0.001). Age was a key predictor for all three conditions (p &lt; 0.001), with sex differences\u2014men had a higher prevalence of pre-sarcopenia (p = 0.014), whereas women showed higher rates of dynapenia (p = 0.003) and sarcopenia (p = 0.008). Low physical activity (p &lt; 0.001), high stress (p = 0.021), and smoking (p = 0.012) were also significant risk factors. Conclusions: These findings highlight the importance of early identification and targeted interventions to prevent muscle deterioration. Public health strategies focusing on lifestyle modifications and sex-specific approaches may help mitigate the burden of sarcopenia and its related health complications in aging populations.<\/jats:p>","DOI":"10.3390\/medicina61040575","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T13:48:20Z","timestamp":1742824100000},"page":"575","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and Associated Factors of Dynapenia, Pre-Sarcopenia, and Sarcopenia in Korean Adults: A Cross-Sectional Epidemiological Study"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-1713","authenticated-orcid":false,"given":"Do-Youn","family":"Lee","sequence":"first","affiliation":[{"name":"College of General Education, Kookmin University, Seoul 02707, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/BOR.0b013e328358d59b","article-title":"Sarcopenia in older adults","volume":"24","author":"Walston","year":"2012","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lee, D.Y., and Shin, S. (2021). Association of Sarcopenia with Osteopenia and Osteoporosis in Community-Dwelling Older Korean Adults: A Cross-Sectional Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11010129"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lee, D.Y., and Shin, S. (2022). Sarcopenia Is Associated with Metabolic Syndrome in Korean Adults Aged over 50 Years: A Cross-Sectional Study. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031330"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/jcsm.13221","article-title":"Sarcopenia and cardiovascular diseases: A systematic review and meta-analysis","volume":"14","author":"Zuo","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Liao, M.C., Yen, C.C., Lin, Y.T., Huang, F.D., and Chang, Y.T. (2022). Sarcopenia is associated with mortality in non-critical elderly patients visiting the emergency department. Front. Med., 9.","DOI":"10.3389\/fmed.2022.1027503"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.nut.2011.12.002","article-title":"What is dynapenia?","volume":"28","author":"Clark","year":"2012","journal-title":"Nutrition"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.32098\/mltj.04.2013.17","article-title":"Strength and muscle mass loss with aging process. Age and strength loss","volume":"3","author":"Keller","year":"2013","journal-title":"Muscles Ligaments Tendons J."},{"key":"ref_8","first-page":"177","article-title":"Clinical definition of sarcopenia","volume":"11","author":"Santilli","year":"2014","journal-title":"Clin. Cases Miner. Bone Metab. Off. J. Ital. Soc. Osteoporos. Miner. Metab. Skelet. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment","volume":"21","author":"Chen","year":"2020","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Rattanasupar, A., Prateepchaiboon, T., Akarapatima, K., Songjamrat, A., Pakdeejit, S., and Chang, A. (2024). Impact of pre-sarcopenia on outcomes of transarterial chemoembolization in unresectable hepatocellular carcinoma. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-70266-0"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s13539-010-0014-2","article-title":"An overview of sarcopenia: Facts and numbers on prevalence and clinical impact","volume":"1","author":"Morley","year":"2010","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.18632\/aging.202567","article-title":"Estimation of sarcopenia prevalence in individuals at different ages from Zheijang province in China","volume":"13","author":"Huang","year":"2021","journal-title":"Aging"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3904\/kjim.2017.182","article-title":"The impact of sarcopenia on health-related quality of life in elderly people: Korean National Health and Nutrition Examination Survey","volume":"34","author":"Sun","year":"2019","journal-title":"Korean J. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jcsm.12411","article-title":"Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis","volume":"10","author":"Yeung","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1002\/cam4.3428","article-title":"Sarcopenia and adverse health-related outcomes: An umbrella review of meta-analyses of observational studies","volume":"9","author":"Xia","year":"2020","journal-title":"Cancer Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1017\/S0029665123003555","article-title":"Nutrition strategies to counteract sarcopenia: A focus on protein, LC n-3 PUFA and precision nutrition","volume":"82","author":"Murphy","year":"2023","journal-title":"Proc. Nutr. Soc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"510801","DOI":"10.1155\/2012\/510801","article-title":"Nutrition and sarcopenia: A review of the evidence and implications for preventive strategies","volume":"2012","author":"Robinson","year":"2012","journal-title":"J. Aging Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/jcsm.13225","article-title":"Exercise for sarcopenia in older people: A systematic review and network meta-analysis","volume":"14","author":"Shen","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lee, D.Y. (2024). Sex-Specific Sarcopenia Prevalence and Risk Factors in the Korean Population: A Cross-Sectional Epidemiological Study. Medicina, 60.","DOI":"10.3390\/medicina60060899"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4082\/kjfm.22.0224","article-title":"Management of Sarcopenia in Primary Care Settings","volume":"44","author":"Won","year":"2023","journal-title":"Korean J. Fam. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2147\/CIA.S438144","article-title":"Obstacles to the Early Diagnosis and Management of Sarcopenia: Current Perspectives","volume":"19","author":"Ooi","year":"2024","journal-title":"Clin. Interv. Aging"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lee, D.Y. (2025). Association Between Chronic Obstructive Pulmonary Disease and Low Muscle Mass in Korean Adults. J. Clin. Med., 14.","DOI":"10.3390\/jcm14041134"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lee, D.Y., and Shin, S. (2023). Sarcopenia and Anemia in Elderly Koreans: A Nationwide Population-Based Study. Healthcare, 11.","DOI":"10.3390\/healthcare11172428"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1900\/RDS.2022.18.157","article-title":"Sarcopenia and Chronic Complications of Type 2 Diabetes Mellitus","volume":"18","author":"Purnamasari","year":"2022","journal-title":"Rev. Diabet. Stud. RDS"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Meng, S., He, X., Fu, X., Zhang, X., Tong, M., Li, W., Zhang, W., Shi, X., and Liu, K. (2024). The prevalence of sarcopenia and risk factors in the older adult in China: A systematic review and meta-analysis. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1415398"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7247","DOI":"10.18632\/aging.202581","article-title":"Impact of adiposity on muscle function and clinical events among elders with dynapenia, presarcopenia and sarcopenia: A community-based cross-sectional study","volume":"13","author":"Kao","year":"2021","journal-title":"Aging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.13066\/kspm.2024.19.3.81","article-title":"Incidence of low grip strength and related factors in the elderly korean","volume":"19","author":"Lee","year":"2024","journal-title":"J. Korean Soc. Phys. Med."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Park, S., and Lee, J.H. (2024). Joint association of sedentary behavior and physical activity domains with depression in Korean adults: Cross-sectional study combining four biennial surveys (2016\u20132022). PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0312029"},{"key":"ref_29","first-page":"319","article-title":"The association between sarcopenia and pulmonary function in Koreans: A cross-sectional study","volume":"15","author":"Lee","year":"2021","journal-title":"Int. J. Gerontol"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.arr.2018.07.005","article-title":"The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans","volume":"47","author":"Wilkinson","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Gonzalez-Freire, M., de Cabo, R., Studenski, S.A., and Ferrucci, L. (2014). The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle. Front. Aging Neurosci., 6.","DOI":"10.3389\/fnagi.2014.00208"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00198-015-3236-5","article-title":"Age-associated declines in muscle mass, strength, power, and physical performance: Impact on fear of falling and quality of life","volume":"27","author":"Trombetti","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e180009","DOI":"10.1590\/1980-549720180009.supl.2","article-title":"Prevalence and associated factors of sarcopenia, dynapenia, and sarcodynapenia in community-dwelling elderly in S\u00e3o Paulo\u2014SABE Study","volume":"21","author":"Alexandre","year":"2019","journal-title":"Rev. Bras. De Epidemiol. Braz. J. Epidemiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"194","DOI":"10.22540\/JFSF-03-194","article-title":"Prevalence and factors associated with sarcopenia and dynapenia in elderly people","volume":"3","author":"Neves","year":"2018","journal-title":"J. Frailty Sarcopenia Falls"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Choi, Y.A., Lee, J.S., and Kim, Y.H. (2022). Association between physical activity and dynapenia in older adults with COPD: A nationwide survey. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-11504-1"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Andreo-L\u00f3pez, M.C., Zarco-Mart\u00edn, M.T., Contreras-Bol\u00edvar, V., and Fern\u00e1ndez-Soto, M.L. (2023). Prevalence of Sarcopenia and Dynapenia and Related Clinical Outcomes in Patients with Type 1 Diabetes Mellitus. Nutrients, 15.","DOI":"10.3390\/nu15234914"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Mitchell, W.K., Williams, J., Atherton, P., Larvin, M., Lund, J., and Narici, M. (2012). Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review. Front. Physiol., 3.","DOI":"10.3389\/fphys.2012.00260"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Della Peruta, C., Lozanoska-Ochser, B., Renzini, A., Moresi, V., Sanchez Riera, C., Bouch\u00e9, M., and Coletti, D. (2023). Sex Differences in Inflammation and Muscle Wasting in Aging and Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054651"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hwang, J., and Park, S. (2022). Gender-Specific Risk Factors and Prevalence for Sarcopenia among Community-Dwelling Young-Old Adults. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19127232"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"E230116","DOI":"10.1530\/JOE-23-0116","article-title":"Postmenopausal osteoporosis coexisting with sarcopenia: The role and mechanisms of estrogen","volume":"259","author":"Lu","year":"2023","journal-title":"J. Endocrinol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1097\/GME.0000000000001866","article-title":"Prevalence of pre-sarcopenia among postmenopausal women younger than 65 years","volume":"28","author":"Orprayoon","year":"2021","journal-title":"Menopause"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3346\/jkms.2013.28.7.1041","article-title":"Sarcopenia and obesity: Gender-different relationship with functional limitation in older persons","volume":"28","author":"Kim","year":"2013","journal-title":"J. Korean Med. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Noh, H.M., and Park, Y.S. (2020). Handgrip strength, dynapenia, and mental health in older Koreans. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-60835-4"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"E843","DOI":"10.1152\/ajpendo.00301.2007","article-title":"Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle","volume":"293","author":"Petersen","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Yang, L., Ran, Q., Yeo, Y.H., Wen, Z., Tuo, S., Li, Y., Yuan, J., Dai, S., Wang, J., and Ji, F. (2025). Sex disparity in the association between alcohol consumption and sarcopenia: A population-based study. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1536488"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2147\/CIA.S132940","article-title":"Relationship between sarcopenia and physical activity in older people: A systematic review and meta-analysis","volume":"12","author":"Steffl","year":"2017","journal-title":"Clin. Interv. Aging"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1158\/0008-5472.CAN-17-3287","article-title":"The importance of body composition in explaining the overweight paradox in cancer\u2014Counterpoint","volume":"78","author":"Caan","year":"2018","journal-title":"Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Abramowitz, M.K., Hall, C.B., Amodu, A., Sharma, D., Androga, L., and Hawkins, M. (2018). Muscle mass, BMI, and mortality among adults in the United States: A population-based cohort study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0198318"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Qiao, Y.S., Chai, Y.H., Gong, H.J., Zhuldyz, Z., Stehouwer, C.D.A., Zhou, J.B., and Sim\u00f3, R. (2021). The Association Between Diabetes Mellitus and Risk of Sarcopenia: Accumulated Evidences From Observational Studies. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.782391"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"112234","DOI":"10.1016\/j.yexcr.2020.112234","article-title":"High glucose-induced oxidative stress accelerates myogenesis by altering SUMO reactions","volume":"395","author":"Liu","year":"2020","journal-title":"Exp. Cell Res."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/575\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:59:03Z","timestamp":1760029143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["medicina61040575"],"URL":"https:\/\/doi.org\/10.3390\/medicina61040575","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,24]]}}}