{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:54:15Z","timestamp":1780080855185,"version":"3.54.0"},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: To contribute to clinical practice by identifying gender-based differences in patients diagnosed with chronic obstructive pulmonary disease (COPD) who are monitored in the intensive care unit due to type 2 respiratory failure. Materials and Methods: The study was planned as a prospective, observational, and cross-sectional investigation. A total of 258 patients, 91 females and 167 males, were included in the study between 2023 and 2024. Demographic data and clinical parameters of COPD patients admitted to intensive care due to hypercapnic respiratory failure and treated with noninvasive ventilation (NIV) were compared between genders. Results: The number of male patients was higher than female patients, while the mean age of female patients was higher than that of males. The body mass index (BMI), morbid obesity, atrial fibrillation, renal disease, heart failure, hypertension, hypothyroidism, the Charlson Comorbidity Index (CCI), and the cardiothoracic ratio were found to be significantly higher in female patients. Emphysema and steroid use in treatment were more common in male patients. In laboratory analyses conducted at the time of admission, the average D-dimer and brain natriuretic peptide (BNP) levels were higher in female patients. The mean arterial carbon dioxide pressure (PaCO2) level assessed prior to discharge was also higher in female patients. Conclusions: Heart failure and risk factors that may lead to heart failure are more prominent in female COPD patients with type 2 respiratory failure. Despite the lower number of female patients compared to males, the significantly higher comorbidity burden in females, as per CCI scores, suggests that medical processes may be more challenging to manage in females. We believe that these findings will contribute to clinical practice and provide clinicians with insights for patient management.<\/jats:p>","DOI":"10.3390\/medicina61040587","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T10:48:58Z","timestamp":1742899738000},"page":"587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gender-Based Differences in COPD Patients with Type 2 Respiratory Failure\u2014Impact on Clinical Practice"],"prefix":"10.3390","volume":"61","author":[{"given":"Tarkan","family":"Ozdemir","sequence":"first","affiliation":[{"name":"Department of Chest Diseases, Ankara Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Ankara Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5078-3176","authenticated-orcid":false,"given":"Ma\u015fide","family":"Ar\u0131","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Ankara Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-380X","authenticated-orcid":false,"given":"Emrah","family":"Ar\u0131","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Mamak Public Hospital, Ankara 06620, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2420-7607","authenticated-orcid":false,"given":"G\u00fcler","family":"Eraslan Do\u011fanay","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ankara Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-9302","authenticated-orcid":false,"given":"Mustafa \u00d6zg\u00fcr","family":"C\u0131r\u0131k","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ankara Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-4570","authenticated-orcid":false,"given":"Melek","family":"Do\u011fanc\u0131","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ankara Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7i\u011fdem","family":"\u00d6zdilekcan","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Ankara Oncology Training and Research Hospital, Ankara 06200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"K\u0131z\u0131lg\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Ankara Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Tu\u011frul","family":"\u015eipit","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Ankara Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S2213-2600(23)00461-7","article-title":"GOLD COPD Report: 2024 Update","volume":"12","author":"Venkatesan","year":"2024","journal-title":"Lancet Respir. Med."},{"key":"ref_2","first-page":"1","article-title":"Deaths: Preliminary data for 2011","volume":"61","author":"Hoyert","year":"2011","journal-title":"Natl. Vital. Stat. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"Mathers","year":"2006","journal-title":"PLoS Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1378\/chest.10-1253","article-title":"COPD in never smokers: Results from the population-based burden of obstructive lung disease study","volume":"139","author":"Lamprecht","year":"2011","journal-title":"Chest"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/S0140-6736(05)67632-5","article-title":"Chronic obstructive pulmonary disease in five Latin Ameri-can cities (the PLATINO study): A prevalence study","volume":"366","author":"Menezes","year":"2005","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12890-022-02074-z","article-title":"Trends in prevalence, mortality, and disability-adjusted life years relating to chronic obstructive pulmonary disease in Europe: An observational study of the global burden of disease database, 2001\u20132019","volume":"22","author":"Marshall","year":"2022","journal-title":"BMC Pulm. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S2213-2600(18)30060-2","article-title":"COPD beyond smoking: New paradigm, novel opportunities","volume":"6","author":"Agusti","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"ref_9","unstructured":"Stoller, J.K., and Geraldine, F. (2022). The evaluation, diagnosis, and treatment of the adult patient with acute hypercapnic respiratory failure. UpToDate, Wolters Kluwer. Available online: https:\/\/www.uptodate.com\/contents\/the-evaluation-diagnosis-and-treatment-of-the-adult-patient-with-acute-hypercapnic-respiratory-failure."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1183\/09031936.97.10061285","article-title":"Mechanisms of worsening gas exchange during acute exacerbations of chronic obstructive pulmonary disease","volume":"10","author":"Roca","year":"1997","journal-title":"Eur. Respir. J."},{"key":"ref_11","unstructured":"National Institute for Health and Care Excellence (2025, March 14). Chronic Obstructive Pulmonary Disease in over 16s: Diagnosis and Management. Available online: https:\/\/www.nice.org.uk\/guidance\/NG115."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1602426","DOI":"10.1183\/13993003.02426-2016","article-title":"Official ERS\/ATS clinical practice guidelines: Noninvasive ventilation for acute respiratory failure","volume":"50","author":"Rochwerg","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)31561-0","article-title":"Sex and gender: Modifiers of health, disease, and medicine","volume":"396","author":"Barnes","year":"2020","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00134-023-07194-6","article-title":"Sex and gender differences in intensive care medicine","volume":"49","author":"Merdji","year":"2023","journal-title":"Intensive Care Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jcrc.2021.05.019","article-title":"Sex differences in illness severity and mortality among adult intensive care patients: A systematic review and meta-analysis","volume":"65","author":"Modra","year":"2021","journal-title":"J. Crit. Care"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/5584_2018_160","article-title":"COPD Course and Comorbidities: Are There Gender Differences?","volume":"1113","author":"Grabicki","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1097\/01.CCM.0000069347.78151.50","article-title":"Gender-related differences in intensive care: A multiple-center cohort study of therapeutic interventions and outcome in critically ill patients","volume":"31","author":"Valentin","year":"2003","journal-title":"Crit. Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1399-6576.2005.00759.x","article-title":"Impact of gender on treatment and outcome of ICU patients","volume":"49","author":"Reinikainen","year":"2005","journal-title":"Acta Anaesthesiol. Scand"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1503\/cmaj.071112","article-title":"Sex-and age-based differences in the delivery and outcomes of critical care","volume":"177","author":"Fowler","year":"2007","journal-title":"CMAJ"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/CC11355","article-title":"Association of gender with outcomes in critically ill patients","volume":"16","author":"Mahmood","year":"2012","journal-title":"Crit. Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1465-9921-15-20","article-title":"Impact of gender on COPD expression in a real-life cohort","volume":"15","author":"Roche","year":"2014","journal-title":"Respir. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/aas.12337","article-title":"Gender differences in randomised, controlled trials in intensive care units","volume":"58","author":"Kristensen","year":"2014","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.2147\/COPD.S163571","article-title":"Trends in intensive care unit admissions of COPD patients from 2003 to 2013 in Taiwan","volume":"13","author":"Liao","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/1475-6773.13215","article-title":"Examining mechanisms for gender differences in admission to intensive care units","volume":"55","author":"Hill","year":"2020","journal-title":"Health Serv. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jcrc.2019.09.023","article-title":"Sex and gender aspects on intensive care. A cohort study","volume":"55","author":"Zettersten","year":"2020","journal-title":"J. Crit. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"106238","DOI":"10.1016\/j.rmed.2020.106238","article-title":"COPD in women\u2014New results presented","volume":"176","author":"Backman","year":"2021","journal-title":"Respir. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/17512433.2021.1888713","article-title":"Sex differences in COPD management","volume":"14","author":"Matera","year":"2021","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00134-021-06393-3","article-title":"Gender differences in the provision of intensive care: A Bayesian approach","volume":"47","author":"Todorov","year":"2021","journal-title":"Intensive Care Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12931-022-02140-4","article-title":"Sex differences in adult asthma and COPD therapy: A systematic review","volume":"23","author":"Rogliani","year":"2022","journal-title":"Respir. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"107090","DOI":"10.1016\/j.rmed.2022.107090","article-title":"Readmission rate for acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis","volume":"206","author":"Ruan","year":"2023","journal-title":"Respir. Med."},{"key":"ref_31","unstructured":"(1995). Physical status: The use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech. Rep. Ser., 854, 1\u2013452."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00000441-191904000-00007","article-title":"The Cardiothoracic Ratio","volume":"157","author":"Danzer","year":"1919","journal-title":"Am. J. Med. Sci."},{"key":"ref_34","unstructured":"World Health Organization (2025, March 03). International Statistical Classification of Diseases and Related Health Problems 10th Revision. Available online: https:\/\/iris.who.int\/handle\/10665\/246208."},{"key":"ref_35","first-page":"132","article-title":"An epidemiologic study of physician-diagnosed chronic obstructive pulmonary disease in the Turkish population: COPDTURKEY-1","volume":"50","author":"Kaya","year":"2020","journal-title":"Turk. J. Med. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/ijcp.12150","article-title":"Unsuspected risk factors of frequent exacerbations requiring hospital admission in chronic obstructive pulmonary disease","volume":"67","author":"Ozyilmaz","year":"2013","journal-title":"Int. J. Clin. Pract."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13054-015-0873-1","article-title":"Gender differences in outcome and use of resources do exist in Swedish intensive care, but to no advantage for women of premenopausal age","volume":"19","author":"Samuelsson","year":"2015","journal-title":"Crit. Care"},{"key":"ref_38","unstructured":"Ba\u015fara, B.B., Ayg\u00fcn, A., \u00d6zdemir, T.A., and Kulali, B. (2025, March 03). Health Statistics Yearbook 2023, Available online: https:\/\/sbsgm.saglik.gov.tr\/TR-93567\/health-statistics-yearbook.html."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13613-019-0514-y","article-title":"Gender and survival of critically ill patients: Results from the FROG-ICU study","volume":"9","author":"Hollinger","year":"2019","journal-title":"Ann. Intensive Care"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"R174","DOI":"10.1186\/cc10323","article-title":"Women receive more trials of noninvasive ventilation for acute respiratory failure than men: A nationwide population-based study","volume":"15","author":"Shen","year":"2011","journal-title":"Crit. Care"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.trsl.2013.05.001","article-title":"Chronic obstructive pulmonary disease and cardiovascular disease","volume":"162","author":"Bhatt","year":"2013","journal-title":"Transl. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"732349","DOI":"10.3389\/fcvm.2021.732349","article-title":"Association of Chronic Obstructive Pulmonary Disease with Arrhythmia Risks: A Systematic Review and Meta-Analysis","volume":"8","author":"Liu","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_43","first-page":"2908","article-title":"Atrial fibrillation in the acute hypercapnic exacerbations of COPD","volume":"18","author":"Terzano","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1164\/rccm.201201-0034OC","article-title":"Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease","volume":"186","author":"Divo","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1753466619860058","DOI":"10.1177\/1753466619860058","article-title":"The impact of comorbidities on mortality among men and women with COPD: Report from the OLIN COPD study","volume":"13","author":"Sawalha","year":"2019","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1177\/0885066618761363","article-title":"Super Obesity in the Medical Intensive Care Unit","volume":"35","author":"Kumar","year":"2020","journal-title":"J. Intensive Care Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Szlagor, M., Dybiec, J., M\u0142ynarska, E., Rysz, J., and Franczyk, B. (2023). Chronic Kidney Disease as a Comorbidity in Heart Failure. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032988"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11883-016-0575-4","article-title":"Obesity and Cardiovascular Disease: A Risk Factor or a Risk Marker?","volume":"18","author":"Mandviwala","year":"2016","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e1159","DOI":"10.1097\/MD.0000000000001159","article-title":"Prognostic Role of Hypothyroidism in Heart Failure: A Meta-Analysis","volume":"94","author":"Ning","year":"2015","journal-title":"Medicine"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1160\/TH13-12-1024","article-title":"Effects of impaired renal function on levels and performance of D-dimer in patients with suspected pulmonary embolism","volume":"112","author":"Bertoletti","year":"2014","journal-title":"Thromb. Haemost."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1164\/rccm.200704-553CC","article-title":"Gender and Chronic Obstructive Pulmonary Disease: Why It Matters","volume":"176","author":"Han","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/587\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:59:43Z","timestamp":1760029183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":51,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["medicina61040587"],"URL":"https:\/\/doi.org\/10.3390\/medicina61040587","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]}}}