{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:33:07Z","timestamp":1777937587827,"version":"3.51.4"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Patent ductus arteriosus (PDA) is common in newborns, being associated with high morbidity and mortality. While maternal and neonatal conditions are known contributors, few studies use advanced machine learning (ML) as predictive factors. This study assessed how maternal pathologies, medications, and neonatal factors affect the risk of PDA using traditional statistics and ML algorithms: Random Forest (RF) and XGBoost (XGB). Materials and Methods: A retrospective 3-year cohort study of 201 NICU neonates assessed maternal and neonatal factors. Logistic regression (LR) and chi-square analyses identified significant predictors, while ML models enhanced predictive accuracy and pinpointed key PDA factors. Results: LR identified prolonged rupture of membranes (&gt;18 h) as the most significant predictor (OR: 13.03, p &lt; 0.001). The ML models identified gestational age, maternal anemia, prenatal care level, birth weight, prolonged rupture of membranes, medication usage, diabetes, pregnancy-induced hypertension, SARS-CoV-2 infection, and cervical cerclage as key predictors. The RF model had 76.3% accuracy, moderate sensitivity (47.4%), and high specificity (90%). XGB performed better with 81.4% accuracy, an AUC of 0.872, sensitivity of 92.5%, and specificity of 57.9%. Conclusions: This study shows that maternal and neonatal factors significantly influence the risk of PDA. ML, particularly XGBoost, enhances predictive abilities, guiding targeted interventions and improving neonatal outcomes.<\/jats:p>","DOI":"10.3390\/medicina61040603","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T06:45:51Z","timestamp":1743144351000},"page":"603","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predicting Risk for Patent Ductus Arteriosus in the Neonate: A Machine Learning Analysis"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0486-0883","authenticated-orcid":false,"given":"Ana Maria Cristina","family":"Jura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u015foara, Romania"},{"name":"Medici\u2019s MedLife Hospital Timi\u0219oara, Ciprian Porumbescu Street No. 9, 300236 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4986-8025","authenticated-orcid":false,"given":"Daniela Eugenia","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u015foara, Romania"},{"name":"Medici\u2019s MedLife Hospital Timi\u0219oara, Ciprian Porumbescu Street No. 9, 300236 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosmin","family":"C\u00eetu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u015foara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2584-3499","authenticated-orcid":false,"given":"Marius","family":"Biri\u0219","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u015foara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Pienar","sequence":"additional","affiliation":[{"name":"2nd Pediatrics Clinic, Department of Pediatrics, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9040-2297","authenticated-orcid":false,"given":"Corina","family":"Paul","sequence":"additional","affiliation":[{"name":"2nd Pediatrics Clinic, Department of Pediatrics, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana Maria","family":"Petrescu","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Clinical Hospital of Obstetrics and Gynecology \u201cProf. Dr. P.Sirbu\u201d, 060251 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0260-8293","authenticated-orcid":false,"given":"Andreea Teodora","family":"Constantin","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-4408","authenticated-orcid":false,"given":"Alexandru","family":"Dinulescu","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4629-5820","authenticated-orcid":false,"given":"Ioana","family":"Ro\u0219ca","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"},{"name":"Neonatology Department, Clinical Hospital of Obstetrics and Gynecology \u201cProf. Dr. P.Sirbu\u201d, 060251 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"ref_1","first-page":"197","article-title":"In Vitro Fertilization as an Independent Risk Factor for Perinatal Complications: Single-Center 10 Years Cohort Study","volume":"27","author":"Singh","year":"2023","journal-title":"JBRA Assist. 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