{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:23:08Z","timestamp":1779243788209,"version":"3.51.4"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Human papillomavirus (HPV) is one of the most prevalent sexually transmitted illnesses. HPV is responsible for genital condyloma lesions. A durable and effective systemic treatment regimen has not been established for HPV-related infections. In the present study, our purpose was to evaluate the role of active hexose correlated compound (AHCC) in preventing relapse in patients who underwent cauterization for condyloma accuminata. Materials and Methods: A total of 244 individuals admitted to our hospital between January 2019 and June 2022 were diagnosed as having condyloma acuminata, and those who underwent condyloma cauterization were evaluated retrospectively. We included 133 individuals who met the criteria. Patients who received AHCC were scheduled for follow-up examinations at regular intervals every three months. Patients were divided into two groups and analyzed based on whether they did or did not use AHCC. Results: The average age of AHCC non-users was significantly greater than that of AHCC users (p &lt; 0.01). The number of condylomas and the maximum condyloma diameter of AHCC users before treatment were found to be significantly higher than in AHCC non-users (p = 0.006 and p = 0.004, respectively). Among participants with recurrence, the number and diameter of condylomas in AHCC users were significantly lower than in AHCC non-users (p = 0.019 and p = 0.042, respectively). Conclusions: Although the usage of AHCC is not expected to help prevent recurrence after the cauterization of condylomata acuminate in all patients, physicians may consider AHCC as a nutritional supplement and supportive therapy in the absence of other systemic treatments. Consequently, the duration of AHCC support necessary to optimize the effect of AHCC use on relapse prevention requires further evaluation on the basis of both target IFN-\u03b2 levels and HPV infection status.<\/jats:p>","DOI":"10.3390\/medicina61040622","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T13:36:49Z","timestamp":1743169009000},"page":"622","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Efficacy of Active Hexose Correlated Compound as an Adjuvant in Reducing Recurrence After Condyloma Cauterization"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2109-1373","authenticated-orcid":false,"given":"Ufuk","family":"Atlihan","sequence":"first","affiliation":[{"name":"Manisa Merkezefendi State Hospital, Manisa 45010, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dokuz Eylul University, Izmir 35020, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-0480","authenticated-orcid":false,"given":"Can","family":"Ata","sequence":"additional","affiliation":[{"name":"Buca Seyfi Demirsoy Training and Research Hospital, Izmir 35020, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin Aytug","family":"Avsar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, T\u0131naztepe Galen University, Izmir 35020, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-6777","authenticated-orcid":false,"given":"Tevfik Berk","family":"Bildaci","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Faculty of Medicine, Izmir Democracy University, Izmir 35020, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Cenk","family":"Ozay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Cyprus International University, Nicosia 1010, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burak","family":"Ersak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ankara Bilkent City Hospital, University of Health Sciences, Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulas","family":"Solmaz","sequence":"additional","affiliation":[{"name":"Private Clinic, Izmir 35020, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"Erkilinc","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine, Izmir Democracy University, Izmir 35020, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"ref_1","first-page":"124","article-title":"Human papilloma virus (HPV) and cervical cancer","volume":"49","author":"Furumoto","year":"2002","journal-title":"J. Med. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/CS20050369","article-title":"Molecular biology of human papillomavirus infection and cervical cancer","volume":"110","author":"Doorbar","year":"2006","journal-title":"Clin. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1067\/S0002-9378(03)00789-0","article-title":"Genital and perianal warts: New treatment opportunities for human papillomavirus infection","volume":"189","author":"Gunter","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Thompson, A.B., and Flowers, L.C. (2020). Human papillomavirus (HPV). Sexually Transmitted Infections in Adolescence and Young Adulthood: A Practical Guide for Clinicians, Springer.","DOI":"10.1007\/978-3-030-20491-4_18"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ijc.24731","article-title":"Age distribution of human papillomavirus infection and cervical neoplasia reflects caveats of cervical screening policies","volume":"126","author":"Chan","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Dursun, P., Senger, S.S., Arslan, H., Ku\u015f\u00e7u, E., and Ayhan, A. (2009). Human papillomavirus (HPV) prevalence and types among Turkish women at a gynecology outpatient unit. BMC Infect. Dis., 9.","DOI":"10.1186\/1471-2334-9-191"},{"key":"ref_7","first-page":"70","article-title":"Analysis of Risk Factors for Human Papilloma Virus (HPV): A Survey Study","volume":"49","author":"Atlihan","year":"2022","journal-title":"Arch. Clin. Psychiatry"},{"key":"ref_8","unstructured":"Ufuk, A., Muzaffer, A., Ahmet G\u00f6khan, S., and Senai, A. (2023). Theoretical and Clinical Approaches in the Light of Current Developments in Health 4, Cervical Cancer Screening and Abnormal Smear Management, Ekin Publishing House."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1056\/NEJMoa020586","article-title":"A controlled trial of a human papillomavirus type 16 vaccine","volume":"347","author":"Koutsky","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_10","first-page":"303","article-title":"Active Hexose Correlated Compound (AHCC) Improves Immunological Parameters and Performance Status of Patients With Solid Tumors","volume":"14","author":"Uno","year":"2000","journal-title":"Biotherapy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1007\/s00262-005-0111-9","article-title":"Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses","volume":"55","author":"Gao","year":"2006","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_12","unstructured":"Takehito, M., Kitadate, K., Nishioka, H., and Wakame, K. (2010). Basic and clinical studies on active hexose correlated compound. Biotechnology in Functional Foods and Nutraceuticals, CRC Press."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.taap.2007.03.031","article-title":"The influence of active hexose correlated compound (AHCC) on cisplatin-evoked chemotherapeutic and side effects in tumor-bearing mice","volume":"222","author":"Hirose","year":"2007","journal-title":"Toxicol Appl. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1248\/yakushi1947.120.8_715","article-title":"Prophylactic efficacy of a basidiomycetes preparation AHCC against lethal opportunistic infections in mice","volume":"120","author":"Ishibashi","year":"2000","journal-title":"Yakugaku Zasshi J. Pharm. Soc. Jpn."},{"key":"ref_15","first-page":"6","article-title":"Evaluation of active hexose correlated compound (AHCC) in combination with pegylated liposomal doxorubicin for treatment of ovarian cancer","volume":"4","author":"Hunter","year":"2011","journal-title":"Int. J. Appl. Res. Nat. Prod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1164\/rccm.200605-722OC","article-title":"Regular smoking and asthma incidence in adolescents","volume":"174","author":"Gilliland","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chiva-Blanch, G., and Badimon, L. (2019). Benefits and Risks of Moderate Alcohol Consumption on Cardiovascular Disease: Current Findings and Controversies. Nutrients, 12.","DOI":"10.3390\/nu12010108"},{"key":"ref_18","first-page":"17455065211020702","article-title":"Human papillomavirus persistence or clearance after infection in reproductive age. What is the status? Review of the literature and new data of a vaginal gel containing silicate dioxide, citric acid, and selenite","volume":"17","author":"Huber","year":"2021","journal-title":"Womens Health"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Shanmugasundaram, S., and Jianxin, Y. (2017). Targeting persistent human papillomavirus infection. Viruses, 9.","DOI":"10.3390\/v9080229"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.jiph.2023.06.016","article-title":"Natural and synthetic drugs and formulations for intravaginal HPV clearance","volume":"16","author":"Khamjan","year":"2023","journal-title":"J. Infect. Public Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fonc.2019.00173","article-title":"From bench to bedside: Evaluation of AHCC supplementation to modulate the host immunity to clear high-risk human papillomavirus infections","volume":"9","author":"Smith","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"881902","DOI":"10.3389\/fonc.2022.881902","article-title":"AHCC\u00ae Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections","volume":"12","author":"Smith","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_23","unstructured":"(2023, April 11). ClinicalTrials, a Resource Provided by the U.S. National Library of Medicine, Available online: https:\/\/clinicaltrials.gov\/."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/AOG.0b013e31825bc6e8","article-title":"Treatment of cervical intraepithelial neoplasia with topical imiquimod: A randomized controlled trial","volume":"120","author":"Grimm","year":"2012","journal-title":"Obstet Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e03224-20","DOI":"10.1128\/mBio.03224-20","article-title":"Development of DNA vaccine targeting E6 and E7 proteins of human papillomavirus 16 (HPV16) and HPV18 for immunotherapy in combination with recombinant vaccine boost and PD-1 antibody","volume":"12","author":"Peng","year":"2021","journal-title":"mBio"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3390\/vaccines2020422","article-title":"Therapeutic vaccine strategies against human papillomavirus","volume":"2","author":"Khallouf","year":"2014","journal-title":"Vaccines"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1038\/ncomms6317","article-title":"Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients","volume":"5","author":"Kim","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/S0140-6736(15)00239-1","article-title":"Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2\/3: A randomised, double-blind, placebo-controlled phase 2b trial","volume":"386","author":"Trimble","year":"2015","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s13258-022-01221-4","article-title":"Correlation between recurrence of anorectal condyloma acuminatum and human papilloma virus subtype","volume":"44","author":"Kim","year":"2022","journal-title":"Genes Genom."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s40001-022-00816-7","article-title":"Establishing a prediction model for recurrence of condyloma acuminatum","volume":"27","author":"Zhan","year":"2022","journal-title":"Eur. J. Med. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/infdis\/jir851","article-title":"Risk factors for incident condyloma in a multinational cohort of men: The HIM study","volume":"205","author":"Anic","year":"2012","journal-title":"J. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1467-842X.2004.tb00443.x","article-title":"Maintaining sexual health in commercial sex workers in Australia: Condom effectiveness, screening, and management after acquiring sexually transmissible infections","volume":"28","author":"Lyttle","year":"2004","journal-title":"Aust. N. Z. J. Public Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1017\/S0950268814002258","article-title":"Alcohol consumption and persistent infection of high-risk human papillomavirus","volume":"143","author":"Oh","year":"2015","journal-title":"Epidemiol. Infect."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/622\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:04:37Z","timestamp":1760029477000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["medicina61040622"],"URL":"https:\/\/doi.org\/10.3390\/medicina61040622","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]}}}