{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:08:45Z","timestamp":1760058525186,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Council of Lithuania (LMTLT)","award":["S-A-UEI-23-7"],"award-info":[{"award-number":["S-A-UEI-23-7"]}]},{"name":"Ministry of Education, Science and Sport of the Republic of Lithuania","award":["S-A-UEI-23-7"],"award-info":[{"award-number":["S-A-UEI-23-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is a well-established technique for evaluating myocardial perfusion and function in patients with suspected or known coronary artery disease. While conventional dual-detector SPECT scanners have limitations in spatial resolution and photon detection sensitivity, recent advancements, including full-ring solid-state cadmium zinc telluride (CZT) detectors, offer enhanced image quality and improved diagnostic accuracy. This study aimed to compare the performance of Veriton-CT, a full-ring CZT SPECT system, with GE Discovery 530c, a dedicated cardiac fixed-angle gamma camera, in myocardial perfusion imaging and their correlation with coronary angiography findings. Materials and Methods: This was a prospective study that analyzed 21 patients who underwent MPI at the Department of Nuclear Medicine, Lithuanian University of Health Sciences, Kauno Klinikos. A one-day stress\u2013rest protocol using 99mTc-Sestamibi was employed, with stress testing performed via bicycle ergometry or pharmacological induction. MPI was first conducted using GE Discovery 530c (GE Health Care, Boston, MA, USA), followed by imaging on Veriton-CT, which included low-dose CT for attenuation correction. The summed stress score (SSS), summed rest score (SRS), and summed difference score (SDS) were analyzed and compared between both imaging modalities. Coronary angiography results were retrospectively collected, and lesion-based analysis was performed to assess the correlation between imaging results and the presence of significant coronary artery stenosis (\u226535% and \u226570% narrowing). Image quality and the certainty of distinguishing the inferior myocardial wall from extracardiac structures were also evaluated by two independent researchers with differing levels of experience. Results: Among the 14 patients included in the final analysis, Veriton-CT was more likely to classify MPI scans as normal (64.3%) compared to GE Discovery 530c (28.6%). Additionally, Veriton-CT provided a better assessment of the right coronary artery (RCA) basin, showing greater agreement with coronary angiography findings than GE Discovery 530c, although the difference was not statistically significant. No significant differences in lesion overlap were observed for the left anterior descending artery (LAD) or left circumflex artery (LCx) basins. Furthermore, the image quality assessment revealed slightly better delineation of extracardiac structures using Veriton-CT (Spectrum Dynamics Medical, Caesarea, Israel), particularly when evaluated by an experienced researcher. However, no significant difference was observed when assessed by a less experienced observer. Conclusions: Our findings suggest that Veriton-CT, with its full-ring CZT detector system, may offer advantages over fixed-angle gamma cameras in improving image quality and reducing attenuation artifacts in MPI. Although the difference in correlations with coronary angiography findings was not statistically significant, Veriton-CT showed a trend toward better agreement, particularly in the RCA basin. These results indicate that full-ring SPECT imaging could improve the diagnostic accuracy of non-invasive MPI, potentially reducing the need for unnecessary invasive angiography. Further studies with larger patient cohorts are required to confirm these findings and evaluate the clinical impact of full-ring SPECT technology in myocardial perfusion imaging.<\/jats:p>","DOI":"10.3390\/medicina61040665","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T14:59:57Z","timestamp":1743778797000},"page":"665","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of Cardiac SPECT Myocardial Perfusion Imaging: Full-Ring Solid-State Detectors Versus Dedicated Cardiac Fixed-Angle Gamma Camera"],"prefix":"10.3390","volume":"61","author":[{"given":"Gytis","family":"Aleksa","sequence":"first","affiliation":[{"name":"Radiology Clinic, Medical Academy, Faculty of Medicine, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulius","family":"Jaru\u0161evi\u010dius","sequence":"additional","affiliation":[{"name":"Radiology Clinic, Medical Academy, Faculty of Medicine, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Department of Nuclear Medicine, Radiology Clinic, Lithuanian University of Health Sciences, Kaunas Clinics, 44307 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u0117","family":"Pacaityt\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatas","family":"Vajauskas","sequence":"additional","affiliation":[{"name":"Radiology Clinic, Medical Academy, Faculty of Medicine, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Department of Nuclear Medicine, Radiology Clinic, Lithuanian University of Health Sciences, Kaunas Clinics, 44307 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.2967\/jnumed.118.220657","article-title":"Solid-State Detector SPECT Myocardial Perfusion Imaging","volume":"60","author":"Slomka","year":"2019","journal-title":"J. Nucl. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC Guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_3","unstructured":"Adnan, G., and Rahman, M.N. (2024). Nuclear Medicine SPECT Scan Cardiovascular Assessment, Protocols, and Interpretation. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1002\/mp.14836","article-title":"Evaluation of a variable-aperture full-ring SPECT system using large-area pixelated CZT modules: A simulation study for brain SPECT applications","volume":"48","author":"Huh","year":"2021","journal-title":"Med. Phys."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"van der Meulen, N.P., Strobel, K., and Lima, T.V.M. (2021). New Radionuclides and Technological Advances in SPECT and PET Scanners. Cancers, 13.","DOI":"10.3390\/cancers13246183"},{"key":"ref_6","first-page":"3003","article-title":"Veriton Multi-CZT Detector SPECT\/CT System Acceptance Testing","volume":"61","author":"Wacholz","year":"2020","journal-title":"J. Nucl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40658-020-0284-5","article-title":"Evaluation of a new multipurpose whole-body CzT-based camera: Comparison with a dual-head Anger camera and first clinical images","volume":"7","author":"Desmonts","year":"2020","journal-title":"EJNMMI Phys."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s12350-019-01702-2","article-title":"First comparison of performances between the new whole-body cadmium-zinc-telluride SPECT-CT camera and a dedicated cardiac CZT camera for myocardial perfusion imaging: Analysis of phantom and patients","volume":"27","author":"Morelle","year":"2020","journal-title":"J. Nucl. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12350-015-0277-2","article-title":"Pitfalls and artifacts using the D-SPECT dedicated cardiac camera","volume":"23","author":"Allie","year":"2016","journal-title":"J. Nucl. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41824-019-0058-2","article-title":"EANM procedural guidelines for myocardial perfusion scintigraphy using cardiac-centered gamma cameras","volume":"3","author":"Hyafil","year":"2019","journal-title":"Eur. J. Hybrid Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2967\/jnumed.111.102434","article-title":"Cadmium-Zinc-Telluride Myocardial Perfusion Imaging in Obese Patients Michael Fiechter","volume":"53","author":"Gebhard","year":"2012","journal-title":"Kaufmann J. Nucl. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/MNM.0b013e3282f28409","article-title":"Comparison between 180\u00b0 and 360\u00b0 acquisition arcs with and without correction by CT-based attenuation maps in normal hearts at rest","volume":"29","author":"Dimitris","year":"2008","journal-title":"Nucl. Med. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1071-3581(98)80005-6","article-title":"Clinical comparison of 180-degree and 360-degree data collection of technetium 99m sestamibi SPECT for detection of coronary artery disease","volume":"5","author":"Freeman","year":"1998","journal-title":"J. Nucl. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2174\/1573405614666181017121453","article-title":"Prone Myocardial Perfusion Imaging and Breast Attenuation: A Phantom Study","volume":"16","author":"Ramos","year":"2020","journal-title":"Curr. Med. Imaging Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2967\/jnmt.120.255943","article-title":"Added Value of CT Attenuation Correction and Prone Positioning in Improving Breast and Subdiaphragmatic Attenuation in Myocardial Perfusion Imaging","volume":"49","author":"Tawakol","year":"2021","journal-title":"J. Nucl. Med. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1007\/s12350-023-03210-w","article-title":"Comparison of positional artifacts in myocardial perfusion imaging in supine and semi-reclining positions using dedicated D-SPECT cardiac camera: Validation using CT-based attenuation correction","volume":"30","author":"Chopra","year":"2023","journal-title":"J. Nucl. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00259-024-06946-w","article-title":"Hybrid cardiovascular imaging. A clinical consensus statement of the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI) of the ESC","volume":"52","author":"Caobelli","year":"2025","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/978-3-030-42618-7_19","article-title":"FDG PET hybrid imaging","volume":"216","author":"Becker","year":"2020","journal-title":"Recent Results Cancer Res."},{"key":"ref_19","first-page":"215","article-title":"The benefit of personalized hybrid SPECT\/CT pulmonary imaging","volume":"6","author":"Simanek","year":"2016","journal-title":"Am. J. Nucl. Med. Mol. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.12659\/PJR.883774","article-title":"Advantages of hybrid SPECT-CT imaging in preoperative localization of parathyroid glands in a patient with secondary hyperparathyroidism: A case report","volume":"78","author":"Cytawa","year":"2013","journal-title":"Pol. J. Radiol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/665\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:10:03Z","timestamp":1760029803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["medicina61040665"],"URL":"https:\/\/doi.org\/10.3390\/medicina61040665","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2025,4,4]]}}}