{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:34:17Z","timestamp":1793144057725,"version":"4.5.0"},"reference-count":31,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Associated mitral regurgitation (MR) is frequently observed during transcatheter aortic valve implantation (TAVI). The progression of moderate MR remains undetermined, given uncertain clinical significance and natural history. This study aims to assess the evolution of moderate MR following TAVI. Materials and Methods: Between 2018 and 2023, 1476 patients underwent TAVI. We excluded those with previous aortic or mitral valve interventions, endocarditis, concomitant percutaneous coronary intervention, or emergent procedures. Patients with severe aortic or tricuspid regurgitation or significant mitral stenosis were excluded. Ultimately, only patients with moderate MR were included, resulting in a final population of 154 patients. Results: Mean age was 81.4 \u00b1 7.8 years, 48.1% (74\/154) were female, and 48.1% (74\/154) were functional MR. There was one surgical conversion due to annular rupture. Thirty-day mortality was 1.9% (3\/154). Postoperative echocardiography showed 38 (24.7%) patients with none\/trace MR, 91 (59.1%) with mild MR, 22 (14.3%) with moderate MR, and 3 (1.9%) with severe MR. Finally, according to the echocardiographic follow-up [median follow-up 1.0 (IQR: 0.1\u20131.2) years], 20.1% (31\/154) had no\/trace MR, 39.6% (61\/154) had mild MR, 35.7% (55\/154) had moderate MR, and 4.5% (7\/154) had severe MR. Overall, 67 (43.5%) patients had any MR grade progression, 62 (40.3%) had stable disease, and 25 (16.2%) had any MR grade reduction at the last follow-up from the operation. No difference in MR evolution was seen between functional and primary MR. Conclusions: Concomitant moderate MR during TAVI has a variable evolution over time. A more detailed characterization of patients with preoperative moderate MR undergoing TAVI is necessary to identify those with a disease progression risk.<\/jats:p>","DOI":"10.3390\/medicina61040686","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T08:46:20Z","timestamp":1744274780000},"page":"686","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evolution of Untreated Moderate Mitral Regurgitation After Transcatheter Aortic Valve Implantation"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3754-6704","authenticated-orcid":false,"given":"Massimo","family":"Baudo","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Sicouri","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-7215","authenticated-orcid":false,"given":"Francesco","family":"Cabrucci","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4363-5156","authenticated-orcid":false,"given":"Yoshiyuki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA"},{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5417-6392","authenticated-orcid":false,"given":"Dimitrios E.","family":"Magouliotis","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Carnila","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra V.","family":"Abramson","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Cardiovascular Imaging Center, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M.","family":"Hawthorne","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Cardiovascular Imaging Center, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Jarrett","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Cardiovascular Imaging Center, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Coady","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Gnall","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA"},{"name":"Department of Interventional Cardiology, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-989X","authenticated-orcid":false,"given":"Sandro","family":"Gelsomino","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht\u2014CARIM, Maastricht University Medical Centre, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basel","family":"Ramlawi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA"},{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"ref_1","first-page":"1395","article-title":"Clinical impact and evolution of mitral regurgitation following transcatheter aortic valve replacement: A meta-analysis","volume":"101","author":"Eltchaninoff","year":"2015","journal-title":"Heart Br. Card. Soc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/CIRCULATIONAHA.119.041080","article-title":"Contemporary Presentation and Management of Valvular Heart Disease: The EURObservational Research Programme Valvular Heart Disease II Survey","volume":"140","author":"Iung","year":"2019","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jcin.2019.11.042","article-title":"Mitral Regurgitation in Low-Flow, Low-Gradient Aortic Stenosis Patients Undergoing TAVR: Insights From the TOPAS-TAVI Registry","volume":"13","author":"Lerakis","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.amjcard.2014.06.022","article-title":"Meta-analysis of mortality outcomes and mitral regurgitation evolution in 4,839 patients having transcatheter aortic valve implantation for severe aortic stenosis","volume":"114","author":"Sannino","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.jcin.2021.02.030","article-title":"Effect of Transcatheter Aortic Valve Replacement on Concomitant Mitral Regurgitation and Its Impact on Mortality","volume":"14","author":"Witberg","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1161\/CIR.0000000000000923","article-title":"2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_8","first-page":"27","article-title":"Outcome characteristics of multiple-valve surgery: Comparison with single-valve procedures","volume":"9","author":"Vassileva","year":"2014","journal-title":"Innov. Phila. Pa"},{"key":"ref_9","first-page":"1261","article-title":"Prognosis of persistent mitral regurgitation in patients undergoing transcatheter aortic valve replacement","volume":"109","author":"Mauri","year":"2020","journal-title":"Clin. Res. Cardiol. Off. J. Ger. Card. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.athoracsur.2017.05.065","article-title":"Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis and Mitral Regurgitation","volume":"104","author":"Mavromatis","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.jacc.2012.02.020","article-title":"Transcatheter aortic valve replacement: Outcomes of patients with moderate or severe mitral regurgitation","volume":"59","author":"Toggweiler","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.amjcard.2015.01.022","article-title":"Meta-analysis of the impact of mitral regurgitation on outcomes after transcatheter aortic valve implantation","volume":"115","author":"Chakravarty","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/CIRCULATIONAHA.113.003885","article-title":"Impact of preoperative moderate\/severe mitral regurgitation on 2-year outcome after transcatheter and surgical aortic valve replacement: Insight from the Placement of Aortic Transcatheter Valve (PARTNER) Trial Cohort A","volume":"128","author":"Barbanti","year":"2013","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/ejcts\/ezr236","article-title":"Impact of preoperative mitral valve regurgitation on outcomes after transcatheter aortic valve implantation","volume":"41","author":"Gasparetto","year":"2012","journal-title":"Eur. J. Cardio-Thorac. Surg. Off. J. Eur. Assoc. Cardio-Thorac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.jcin.2016.05.025","article-title":"Mitral Regurgitation After Transcatheter Aortic Valve Replacement: Prognosis, Imaging Predictors, and Potential Management","volume":"9","year":"2016","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_16","first-page":"526","article-title":"Impact of mitral regurgitation aetiology on the outcomes of transcatheter aortic valve implantation","volume":"19","author":"Doldi","year":"2023","journal-title":"EuroIntervention J. Eur. Collab. Work. Group Interv. Cardiol. Eur. Soc. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Vandenbroucke, J.P., von Elm, E., Altman, D.G., G\u00f8tzsche, P.C., Mulrow, C.D., Pocock, S.J., Poole, C., Schlesselman, J.J., and Egger, M. (2007). STROBE Initiative Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration. PLoS Med., 4.","DOI":"10.1371\/journal.pmed.0040297"},{"key":"ref_18","first-page":"e20230012","article-title":"Prognostic Impact of Residual Moderate Mitral Regurgitation Following Valve-in-Valve Transcatheter Aortic Valve Implantation","volume":"39","author":"Stankowski","year":"2023","journal-title":"Braz. J. Cardiovasc. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.amjcard.2022.04.049","article-title":"Impact of Transcatheter Aortic Valve Implantation Among Patients With Co-existing Mild to Moderate Mitral Regurgitation","volume":"177","author":"Twing","year":"2022","journal-title":"Am. J. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1159\/000506624","article-title":"Does the Presence of Significant Mitral Regurgitation prior to Transcatheter Aortic Valve Implantation for Aortic Stenosis Impact Mortality?\u2014Meta-Analysis and Systematic Review","volume":"145","author":"Sethi","year":"2020","journal-title":"Cardiology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.jacc.2014.02.573","article-title":"Significant mitral regurgitation left untreated at the time of aortic valve replacement: A comprehensive review of a frequent entity in the transcatheter aortic valve replacement era","volume":"63","author":"Ribeiro","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_22","first-page":"272","article-title":"Outcome and improvement predictors of mitral regurgitation after transcatheter aortic valve implantation","volume":"20","author":"Durst","year":"2011","journal-title":"J. Heart Valve Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.jcin.2020.03.052","article-title":"Transcatheter Aortic Valve Replacement in Patients With Multivalvular Heart Disease","volume":"13","author":"Khan","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.amjcard.2015.11.064","article-title":"Impact of Functional Versus Organic Baseline Mitral Regurgitation on Short- and Long-Term Outcomes After Transcatheter Aortic Valve Replacement","volume":"117","author":"Kiramijyan","year":"2016","journal-title":"Am. J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.athoracsur.2023.02.008","article-title":"Outcomes of Transcatheter Aortic Valve Replacement in Patients With Concomitant Aortic Regurgitation","volume":"116","author":"Yousef","year":"2023","journal-title":"Ann. Thorac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1161\/CIRCULATIONAHA.113.001822","article-title":"Interplay between mitral regurgitation and transcatheter aortic valve replacement with the CoreValve Revalving System: A multicenter registry","volume":"128","author":"Bedogni","year":"2013","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.amjcard.2020.06.037","article-title":"Impact of Combined Pre and Postcapillary Pulmonary Hypertension on Survival after Transcatheter Aortic Valve Implantation","volume":"131","author":"Sultan","year":"2020","journal-title":"Am. J. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.jacc.2016.03.514","article-title":"Impact of Ejection Fraction and Aortic Valve Gradient on Outcomes of Transcatheter Aortic Valve Replacement","volume":"67","author":"Baron","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.33963\/KP.15680","article-title":"Impact of transcatheter aortic valve implantation on coexistent mitral regurgitation parameters","volume":"79","author":"Grodecki","year":"2021","journal-title":"Kardiol. Pol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ccd.22197","article-title":"Changes in mitral regurgitation after transcatheter aortic valve implantation","volume":"75","author":"Tzikas","year":"2010","journal-title":"Catheter. Cardiovasc. Interv. Off. J. Soc. Card. Angiogr. Interv."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1002\/ehf2.13946","article-title":"Prognostic relevance of B-type natriuretic peptide in patients with moderate mixed aortic valve disease","volume":"9","author":"Onishi","year":"2022","journal-title":"ESC Heart Fail."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/686\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:13:02Z","timestamp":1760029982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/4\/686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["medicina61040686"],"URL":"https:\/\/doi.org\/10.3390\/medicina61040686","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]}}}