{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:42:58Z","timestamp":1789504978930,"version":"build-2803163510"},"reference-count":19,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: We aimed to assess the outcomes of upfront Optilume drug-coated balloon (DCB) dilation in patients after failed treatment for complex recurrent urethral stricture disease. All patients presented with acute urinary retention and were treated with DCB dilation regardless of stricture site and length. Materials and Methods: We retrospectively evaluated patients with acute urinary retention and known complex recurrent urethral strictures. Patients presented at the urology emergency room of our tertiary centre with an inability to void or a post-void residual (PVR) volume exceeding 400 mL between August 2021 and February 2024. Urethrography and\/or endoscopic imaging confirmed the diagnosis. Patients with urinary tract infection\/sepsis and those with neurological disease were excluded. Urethral dilation to 20 Fr was performed, followed by DCB dilation (30 Fr, 10 bar, 10 min). The primary endpoints were anatomical success (\u226514 Fr by cystoscopy\/calibration) at 12 months and freedom from repeat interventions. Results: Thirty-one consecutive male patients were evaluated, with twenty-six patients followed for \u226512 months (mean age 65 \u00b1 16.8 years). The stricture sites included seven bulbopenile, seven bulbomembranous, seven anastomotic, three bladder neck, one penile, and one panurethral stricture. The median number of prior urethral\/surgical interventions was 2 [IQR: 1\u20133] (range: 1\u201331). The median stricture length was 3 [IQR: 2\u20134] cm (range: 1\u20138). At 12 months, 65.4% (17\/26) of subjects voided satisfactorily and were free of recurrence and reoperation. Conclusions: Timely DCB dilation may offer a viable treatment option for patients with complex recurrent urethral strictures and urinary retention, particularly those who are unable or unwilling to undergo surgical reconstruction and prefer to avoid indwelling catheters.<\/jats:p>","DOI":"10.3390\/medicina61040700","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:38:26Z","timestamp":1744349906000},"page":"700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optilume Drug-Coated Balloon for Acute Urinary Retention After Failed Treatment for Complex Recurrent Urethral Stricture Disease"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3606-2841","authenticated-orcid":false,"given":"Lukas Andrius","family":"Jelisejevas","sequence":"first","affiliation":[{"name":"Department of Urology, Medical University Innsbruck, 6020 Innsbruck, Tyrol, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1739-5523","authenticated-orcid":false,"given":"Peter","family":"Rehder","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University Innsbruck, 6020 Innsbruck, Tyrol, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannik","family":"Wassermann","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University Innsbruck, 6020 Innsbruck, Tyrol, Austria"},{"name":"Department of Urology, Tauernklinikum Zell am See, 6700 Zell am See, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Kink","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University Innsbruck, 6020 Innsbruck, Tyrol, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-1544","authenticated-orcid":false,"given":"Gennadi","family":"Tulchiner","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University Innsbruck, 6020 Innsbruck, Tyrol, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/bco2.312","article-title":"Optilume drug-coated balloon for anterior urethral stricture: 2-year results of the ROBUST III trial","volume":"5","author":"VanDyke","year":"2024","journal-title":"BJUI Compass"},{"key":"ref_2","first-page":"90","article-title":"Long-Term Outcomes of Recurrent Bulbar Urethral Stricture Treatment with the Optilume Drug-Coated Balloon: Five-Year Results from the ROBUST I Study","volume":"213","author":"DeLong","year":"2024","journal-title":"J. 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