{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:10:52Z","timestamp":1760058652402,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Hip surgery is increasingly performed among elderly patients. Oral antithrombotics, which are taken for patients\u2019 underlying diseases, are a main concern regarding perioperative bleeding. Postoperative venous thromboembolism (VTE) is a leading cause of mortality after hip surgery. Therefore, administration of preoperative oral antithrombotics is a double-edged sword in hip surgery. In this study, we examined the correlation between the occurrence of postoperative VTE and the type of oral antithrombotics administered preoperatively. Materials and Methods: We analyzed the medical records of 601 patients aged 19 and over who underwent hip surgery from January 2021 to June 2023. The patients were assigned to two groups as follows: Groups VTE+ (patients who developed postoperative VTE) and VTE- (patients who did not develop postoperative VTE), respectively. Results: Of the 139 patients who had been taking oral antithrombotics for 6 months or more, 24 were allocated to group VTE+ and 115 to group VTE-, respectively. The number of patients who took clopidogrel and cilostazol was significantly higher in groups VTE- and VTE+, respectively (12.5 vs. 33.9%, p = 0.038, odds ratio (OR) = 0.278, 95% confidence interval (CI) = 0.078\u20130.991; 20.8 vs. 5.2%, p = 0.010, 95% CI = 1.325\u201317.245; group VTE+ vs. group VTE-). Preoperative albumin levels were significantly lower in group VTE+ (3.4 \u00b1 0.6 g\/dL vs. 3.7 \u00b1 0.4 g\/dL, p = 0.004, OR = 0.285, 95% CI = 0.115\u20130.702). In multivariate regression analysis, the results were statistically significant for clopidogrel, cilostazol, and preoperative albumin levels (p = 0.035, OR = 0.237, 95% CI = 0.062\u20130.901; p = 0.011, OR = 6.479, 95% CI = 1.542\u201327.226; p = 0.002, OR = 0.211, 95% CI = 0.080\u20130.558). Conclusions: Among the patients who had been taking oral antithrombotics for \u22656 months, clopidogrel had a prophylactic effect, but cilostazol showed an aggravating effect on postoperative VTE in hip surgery. Preoperative hypoalbuminemia increases the risk of postoperative VTE in hip surgery.<\/jats:p>","DOI":"10.3390\/medicina61040729","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T08:11:39Z","timestamp":1744704699000},"page":"729","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Type of Preoperative Oral Antithrombotics as a Risk Factor for Venous Thromboembolism After Hip Surgery: A Retrospective Study"],"prefix":"10.3390","volume":"61","author":[{"given":"Yea-Ji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Konkuk University Medical Centre, Seoul 05030, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaemoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Konkuk University Medical Centre, Seoul 05030, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Wan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Konkuk University Medical Centre, Seoul 05030, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7764-9818","authenticated-orcid":false,"given":"Seong-Hyop","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Konkuk University Medical Centre, Seoul 05030, Republic of Korea"},{"name":"Department of Infection and Immunology, School of Medicine, Konkuk University, Seoul 05030, Republic of Korea"},{"name":"Research Institute of Medical Science, School of Medicine, Konkuk University, Seoul 05030, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.anclin.2018.04.001","article-title":"Update on Selective Regional Analgesia for Hip Surgery Patients","volume":"36","author":"Bugada","year":"2018","journal-title":"Anesthesiol. 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