{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:05:11Z","timestamp":1792451111292,"version":"4.5.0"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Provincial Secretariat for Higher Education and Scientific Research, Autonomous Province of Vojvodina, Republic of Serbia","award":["142-451-3187\/2023-01"],"award-info":[{"award-number":["142-451-3187\/2023-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Coronary artery bypass graft (CABG) surgery is the most common cardiac surgery. One of the main causes of postoperative complications and increased mortality after CABG is the inflammatory response. The aim of this study was to investigate whether continuous intraoperative dexmedetomidine can reduce the increase of IL-6 and other inflammatory markers after CABG surgery. Materials and Methods: The study is registered with ClinicalTrials.gov, NCT06378827, accessed on 23 April 2024. This prospective experimental study was conducted from April to December 2024 and included 100 patients undergoing CABG surgery. Patients in the experimental group (50 patients) received a continuous infusion of dexmedetomidine (0.5 \u03bcg\/kg\/h) from anesthesia induction until the end of surgery, while the patients in the control group (50 patients) received the same volume of saline. The primary outcomes were the changes in the values of interleukin-6 (IL-6), C-reactive protein (CRP), white blood cells (WBC), and fibrinogen on the first postoperative day (POD1) compared to the basal, preoperative values. Results: The patients in the control group were on average 65.26 years old, and the patients in the experimental group were 66.28 years old (p = 0.555). From the control group, 40 (80%) patients were male compared to 37 (74%) patients from the experimental group (p = 0.635). Median IL-6 before surgery was 2.0 pg\/mL, while on POD 1 it was 76.2 pg\/mL (p &lt; 0.001). Median CRP before surgery was 2.5 mg\/dL, while the POD1 value was 45.5 mg\/dL (p &lt; 0.001). Median WBC values were 6.7 \u00d7 109\/L before surgery and 13.6 \u00d7 109\/L on POD1 (p &lt; 0.001). The average value of fibrinogen was 3.19 g\/L before surgery, while on POD1 it was 3.37 g\/L (p = 0.024). The increase in IL-6 on POD1 (\u0394IL-6) was 72.4 pg\/mL in the control group and 73.0 pg\/mL in the experimental group (p = 0.427). \u0394CRP was 41.2 mg\/mL (control group) and 38.0 mg\/mL (experimental group) (p = 0.725). \u0394WBC was 7.45 \u00d7 109\/L (control group) and 6.81 \u00d7 109\/L (experimental group) (p = 0.407). \u0394fibrinogen was 0.16 g\/L (control group) and 0.2 g\/L (experimental group) (p = 0.771). Conclusions: Intraoperative administration of dexmedetodine during CABG surgery at a dose of 0.5 \u00b5g\/kg\/h without a loading dose does not lead to a decrease in the intensity of the inflammatory response after surgery.<\/jats:p>","DOI":"10.3390\/medicina61050787","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T08:08:41Z","timestamp":1745482121000},"page":"787","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Continuous Intraoperative Dexmedetomidine on Interleukin-6 and Other Inflammatory Markers After Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-6771","authenticated-orcid":false,"given":"Ranko","family":"Zdravkovi\u0107","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, 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Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora","family":"Tubi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Clinical Center of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neboj\u0161a","family":"Videnovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Pristina, 38220 Kosovska Mitrovica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Mladenovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases of Vojvodina, 21208 Sremska Kamenica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2098-6646","authenticated-orcid":false,"given":"Nikola","family":"Komazec","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases of Vojvodina, 21208 Sremska Kamenica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Dra\u010dina","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases of Vojvodina, 21208 Sremska Kamenica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Jerkovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Clinical Center of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Djokovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Internal Medicine, Clinical Hospital Center Kosovska Mitrovica, 38220 Kosovska Mitrovica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Jakovljevi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Pristina, 38220 Kosovska Mitrovica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arijeta","family":"Kosti\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Pristina, 38220 Kosovska Mitrovica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdin","family":"Mehmedi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Pristina, 38220 Kosovska Mitrovica, 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Cell Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1161\/CIR.0000000000001039","article-title":"2021 ACC\/AHA\/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Lawton","year":"2022","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.21037\/jtd.2018.02.43","article-title":"Fifty years of coronary artery bypass grafting","volume":"10","author":"Melly","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"FSO959","DOI":"10.2144\/fsoa-2023-0152","article-title":"Enhancing mortality prediction after coronary artery bypass graft: A machine learning approach utilizing EuroScore","volume":"10","author":"Hijazi","year":"2024","journal-title":"Future Sci. OA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s13019-024-02943-0","article-title":"Long-term mortality after isolated coronary artery bypass grafting and risk factors for mortality","volume":"19","author":"Chua","year":"2024","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e13907","DOI":"10.1111\/cts.13907","article-title":"Early administration of ketorolac after cardiac surgery and postoperative complications: Analysis of the MIMIC-IV database","volume":"17","author":"Liu","year":"2024","journal-title":"Clin. Transl. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.5937\/jomb0-47001","article-title":"Significance of Galectin-3 and N-terminal pro b-type natriuretic peptide in the prediction of atrial fibrillation after cardiac surgery","volume":"43","author":"Velicki","year":"2024","journal-title":"J. Med. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1093\/eurheartj\/ehae267","article-title":"Anticoagulation for post-operative atrial fibrillation after isolated coronary artery bypass grafting: A meta-analysis","volume":"45","author":"Daeter","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e018097","DOI":"10.1161\/JAHA.120.018097","article-title":"AdipoRon Attenuates Inflammation and Impairment of Cardiac Function Associated with Cardiopulmonary Bypass\u2013Induced Systemic Inflammatory Response Syndrome","volume":"10","author":"Jenke","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1053\/j.jvca.2024.12.013","article-title":"Impact of Inflammation After Cardiac Surgery on 30-Day Mortality and Machine Learning Risk Prediction","volume":"39","author":"Squiccimarro","year":"2025","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/heartjnl-2014-307057","article-title":"Systemic inflammatory response syndrome after transcatheter or surgical aortic valve replacement","volume":"101","author":"Lindman","year":"2015","journal-title":"Heart"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kr\u00fcger, B.D., Hofer, G.E., Rudiger, A., Spahn, G.H., Braun, J., Bettex, D., Schoedon, G., and Spahn, D.R. (2022). Wingless-related integration site (WNT) signaling is activated during the inflammatory response upon cardiac surgery: A translational study. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.997350"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Oremus, Z.S., Bradic, N., Gospic, I., Preseki, I., Sakan, S., Sojcic, N., Oremus, K., Baric, D., Sotosek, V., and Rudez, I. (2025). Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement. Life, 15.","DOI":"10.3390\/life15040524"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.jgo.2020.01.013","article-title":"The association between the inflammatory response to surgery and postoperative complications in older patients with cancer; A prospective prognostic factor study","volume":"11","author":"Plas","year":"2020","journal-title":"J. Geriatr. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e40792","DOI":"10.1097\/MD.0000000000040792","article-title":"Procalcitonin, C-reactive protein, and white blood cell count levels in end-stage cancer patients: A retrospective study on inflammatory markers and their prognostic value","volume":"103","author":"Zhou","year":"2024","journal-title":"Medicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1038\/s41467-022-32222-2","article-title":"Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations","volume":"13","author":"Foy","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Sui, J., Noubouossie, D.F., Gandotra, S., and Cao, L. (2021). Elevated Plasma Fibrinogen Is Associated with Excessive Inflammation and Disease Severity in COVID-19 Patients. Front. Cell Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.734005"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.bja.2019.07.027","article-title":"Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: Systematic review and meta-analysis","volume":"123","author":"Wang","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/ACO.0000000000001207","article-title":"Cardiac surgery, ICU sedation, and delirium: Is dexmedetomidine the silver bullet?","volume":"36","author":"Smith","year":"2023","journal-title":"Cur. Opin. Anaesthesiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"110765","DOI":"10.1016\/j.jocn.2024.110765","article-title":"Dexmedetomidine for awake craniotomy: Systematic review and meta-analysis","volume":"127","author":"Akavipat","year":"2024","journal-title":"J. Clin. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1053\/j.jvca.2024.01.006","article-title":"Dexmedetomidine and Perioperative Arrhythmias","volume":"38","author":"Duan","year":"2024","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Tan, C., Yan, S., Shen, J., Wu, H., Yu, L., Wang, Y., Tian, S., Zhou, W., Wu, Y., and Zhang, Z. (2022). Effects of dexmedetomidine on cardiac electrophysiology in patients undergoing general anesthesia during perioperative period: A randomized controlled trial. BMC Anesthesiol., 22.","DOI":"10.1186\/s12871-022-01811-5"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/anae.12636","article-title":"The effects of dexmedetomidine on inflammatory mediators after cardiopulmonary bypass","volume":"69","author":"Ueki","year":"2014","journal-title":"Anaesthesia"},{"key":"ref_24","unstructured":"Okiljevic, B., Zdravkovic, R., Preveden, A., Preveden, M., Mladenovic, N., and Susak, S. (2024). The Effect of Silymarin on the Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting. Braz. J. Cardiovasc. Surg., e20230422."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Aslan Sirakaya, H., Sipahioglu, H., Cetinkaya, A., and Aydin, K. (2025). Relationship Between Inflammatory Markers (IL-6, Neutrophil\u2013Lymphocyte Ratio, and C-Reactive Protein-Albumin Ratio) and Diabetic Ketoacidosis Severity: Correlation with Clinical Outcomes. Medicina, 61.","DOI":"10.3390\/medicina61020321"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/archsurg.141.11.1132","article-title":"Cell Response to Surgery","volume":"141","year":"2006","journal-title":"Arch. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Moon, J., Chun, D.H., Kong, H.J., Lee, H.S., Jeon, S., Park, J., Kim, N.Y., and Kim, H.I. (2023). The Intraoperative Administration of Dexme-detomidine Alleviates Postoperative Inflammatory Response in Patients Undergoing Laparoscopy-Assisted Gastrectomy: A Double-Blind Randomized Controlled Trial. Biomedicines, 11.","DOI":"10.3390\/biomedicines11123253"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40001-021-00501-1","article-title":"EuroScore and IL-6 predict the course in ICU after cardiac surgery","volume":"26","author":"Bauer","year":"2021","journal-title":"Eur. J. Med. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"440","DOI":"10.5603\/KP.a2017.0242","article-title":"Baseline and postoperative levels of C-reactive protein and interleukins as inflammatory predictors of atrial fibrillation following cardiac surgery: A systematic review and meta-analysis","volume":"76","author":"Weymann","year":"2018","journal-title":"Kardiol. Pol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5492\/wjccm.v11.i4.219","article-title":"Challenges in hyperglycemia management in critically ill patients with COVID-19","volume":"11","author":"Kethireddy","year":"2022","journal-title":"World J. Crit. Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Li, B., and Ning, B. (2022). Evaluating IL-6 and IL-10 as rapid diagnostic tools for Gram-negative bacteria and as disease severity predictors in pediatric sepsis patients in the intensive care unit. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1043968"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1053\/j.jvca.2023.04.008","article-title":"Effect of Dexmedetomidine on Postoperative Renal Function in Patients Undergoing Cardiac Valve Surgery Under Cardiopulmonary Bypass: A Randomized Clinical Trial","volume":"37","author":"Qiu","year":"2023","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1016\/j.asjsur.2024.04.028","article-title":"Effects of dexmedetomidine on renal function after cardiac surgery for infective endocarditis: An interim analysis of a randomized controlled trial","volume":"47","author":"Ham","year":"2024","journal-title":"Asian J. of Surg."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lee, J., Hwang, H.W., Jeong, J.Y., Kim, Y.M., Park, C., and Kim, J.Y. (2022). The Effect of Low-Dose Dexmedetomidine on Pain and Inflammation in Patients Undergoing Laparoscopic Hysterectomy. JCM, 11.","DOI":"10.3390\/jcm11102802"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e37931","DOI":"10.1097\/MD.0000000000037931","article-title":"Impact of intraoperative dexmedetomidine on postoperative delirium and pro-inflammatory cytokine levels in elderly patients undergoing thoracolumbar compression fracture surgery: A prospective, randomized, placebo-controlled clinical trial","volume":"103","author":"Ye","year":"2024","journal-title":"Medicine"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Bulow, N.M.H., Colpo, E., Pereira, R.P., Correa, E.F.M., Waczuk, E.P., Duarte, M.F., and Rocha, J.B.T. (2016). Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass. Braz. J. Med. Biol. Res., 49.","DOI":"10.1590\/1414-431X20154646"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1186\/s13054-020-03207-8","article-title":"Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: A sub-analysis of a multicenter randomized clinical trial","volume":"24","author":"Ohta","year":"2020","journal-title":"Crit. Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/13547500701617708","article-title":"Correlation between two markers of inflammation, serum C-reactive protein and interleukin 6, and indices of oxidative stress in patients with high risk of cardiovascular disease","volume":"13","author":"Ivanova","year":"2008","journal-title":"Biomarkers"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Guo, D., Qin, L., Sun, J., Li, K., Zang, C., Wang, Q., Qiao, W., Liu, B., Zhao, Y., and Zhang, Y. (2023). Dynamic Changes of Cytokine Profiles and Their Correlation with Tumor Recurrence Following Thermal Ablation in Hepatocellular Carcinoma. Technol. Cancer Res. Treat., 15330338231190644.","DOI":"10.1177\/15330338231190644"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Cronj\u00e9, H.T., Nienaber-Rousseau, C., Zandberg, L., de Lange, Z., Green, F.R., and Pieters, M. (2017). Fibrinogen and clot-related phenotypes determined by fibrinogen polymorphisms: Independent and IL-6-interactive associations. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187712"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/5\/787\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:20:43Z","timestamp":1760030443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/5\/787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["medicina61050787"],"URL":"https:\/\/doi.org\/10.3390\/medicina61050787","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,24]]}}}