{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:13:22Z","timestamp":1760058802279,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objective: This study\u2019s objective was to determine the impact of the percentage of lung tissue within the normal density range (PLND) on exacerbations and hospitalizations compared with the modified Bhalla and Reiff scores. We also investigated the effects of these measures on pulmonary function tests (PFTs). Materials and Methods: This retrospective analysis involved adult cystic fibrosis (CF) patients who had thoracic computed tomography (CT) while in a stable clinical condition. A dedicated radiologist analyzed CT images and conducted modified Bhalla, Reiff, and PLND assessments. We analyzed the exacerbations and hospitalizations in the year after the CT scan. We also examined PFTs at the time of the CT scan and one year later. Results: This study\u2019s population consisted of 63 subjects (33 men), with a median age of 23.2 years. The median modified Bhalla score was 9.0 (IQR: 7.0\u201312.0), the median Reiff score was 11.0 (IQR: 8.0\u201315.0), and the median PLND was 79.4% (IQR: 74.5\u201382.0). The Bhalla score had the strongest relationship with both the number of exacerbations (p &lt; 0.001, r: \u22120.559) and hospitalizations the following year (p &lt; 0.001, r: \u22120.636), followed by the PLND score and the Reiff score. Youden\u2019s index shows that the optimum cut-off values for hospitalization at \u22642 and &gt;2 are 6.5 for the modified Bhalla score, 13.5 for the Reiff score, and 76.5% for the PLND. Conclusions: The measurement of PLND may serve as a predictor for exacerbation and hospitalization rates, aligning with the modified Bhalla and Reiff scores, and shows potential for application in follow-up assessments.<\/jats:p>","DOI":"10.3390\/medicina61050808","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:42:37Z","timestamp":1746391357000},"page":"808","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Significance of Density Measurement and the Modified Bhalla and Reiff Scores in Predicting Exacerbations and Hospital Admissions in Cystic Fibrosis Patients"],"prefix":"10.3390","volume":"61","author":[{"given":"O\u011fuz","family":"Karc\u0131o\u011flu","sequence":"first","affiliation":[{"name":"Department of Chest Diseases, School of Medicine, Hacettepe University, Ankara 06100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selin","family":"Ardal\u0131 D\u00fczg\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Hacettepe University, Ankara 06100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1001\/archpedi.1938.01980140114013","article-title":"Cystic fibrosis of the pancreas and its relation to celiac disease: A clinical and pathologic study","volume":"56","author":"Andersen","year":"1938","journal-title":"Am. 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