{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:55:22Z","timestamp":1787028922455,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Royal Columbian Hospital Foundation","award":["FHA2021-CAS"],"award-info":[{"award-number":["FHA2021-CAS"]}]},{"name":"Royal Columbian Hospital Foundation","award":["FHA2017-001"],"award-info":[{"award-number":["FHA2017-001"]}]},{"name":"Surrey Hospitals Foundation","award":["FHA2021-CAS"],"award-info":[{"award-number":["FHA2021-CAS"]}]},{"name":"Surrey Hospitals Foundation","award":["FHA2017-001"],"award-info":[{"award-number":["FHA2017-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The benefit of carotid artery stenting (CAS) for stroke prevention has been established, but less is known about CAS\u2019s effect on cognition. Here, we investigate (1) changes in the blood flow in both treated and non-treated carotid arteries, (2) associations between the severity of artery occlusion and CAS-induced flow change, and (3) whether the flow changes relate to cognitive improvement. Materials and Methods: We used quantitative flow magnetic resonance imaging to assess blood flow and computerized neurocognitive assessment to evaluate cognitive performance. Fourteen patients identified for CAS as part of their standard care participated in this study; ten completed the CAS procedure and the pre- and post-CAS assessments (age = 77.0 \u00b1 5.6; 70% males). Results: An increased ipsilateral flow following CAS was seen in 70% of the participants, while 50% also showed an increase in the total flow. The participants with \u226590% stenosis showed the greatest flow changes, such that the post-CAS flow was 60% higher relative to pre-CAS (p &lt; 0.050). Cognitive responses to the flow increase were variable: attention showed a positive association; in comparison, higher cognitive flexibility and memory were only seen when treated stenosis was below 80%. Conclusions: Our preliminary findings highlight the impact of CAS and the complex relationship between blood flow and cognitive changes post-CAS, warranting larger-scale studies with extended follow-up periods.<\/jats:p>","DOI":"10.3390\/medicina61050848","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T03:05:15Z","timestamp":1746414315000},"page":"848","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Carotid Artery Stenting Intervention to Enhance Global Brain Blood Flow and Cognition in Carotid Artery Disease: Preliminary Findings from a Prospective Follow-Up MRI Study"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2746-2263","authenticated-orcid":false,"given":"Raminder","family":"Kaur","sequence":"first","affiliation":[{"name":"Research and Evaluation, Fraser Health Authority, Surrey, BC V3T 0H1, Canada"},{"name":"Biomedical Physiology & Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Summers","sequence":"additional","affiliation":[{"name":"SFU ImageTech Lab, Surrey Memorial Hospital, 13750 96 Avenue, Surrey, BC V3V 1Z2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Siu","sequence":"additional","affiliation":[{"name":"Medical Imaging, Royal Columbian Hospital, New Westminster, BC V3L 3W7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9941-876X","authenticated-orcid":false,"given":"George","family":"Medvedev","sequence":"additional","affiliation":[{"name":"Division of Neurology, Royal Columbian Hospital, New Westminster, BC V3L 3W7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam M.","family":"Doesburg","sequence":"additional","affiliation":[{"name":"Biomedical Physiology & Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9589-2520","authenticated-orcid":false,"given":"Xiaowei","family":"Song","sequence":"additional","affiliation":[{"name":"Research and Evaluation, Fraser Health Authority, Surrey, BC V3T 0H1, Canada"},{"name":"Biomedical Physiology & Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1007\/s00330-013-2899-6","article-title":"Haemodynamic alterations in cerebral blood vessels after carotid artery revascularisation: Quantitative analysis using 2D phase-contrast MRI","volume":"23","author":"Youn","year":"2013","journal-title":"Eur. 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