{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:29:29Z","timestamp":1769927369447,"version":"3.49.0"},"reference-count":26,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Arteriovenous malformations (AVMs) are abnormal connections between arteries and veins, lacking a normal capillary network. Seizures are a common clinical manifestation in patients with brain AVMs, ranking as the second most frequent presentation. The objective of this study was to evaluate the dynamics of seizure activity in patients with brain AVMs following surgical treatment. Materials and Methods: This study included 27 patients with brain AVMs who underwent microsurgical AVM resection for symptomatic epilepsy. All surgical interventions were performed at JSC \u201cNational Centre for Neurosurgery\u201d between 2008 and 2020. Results: Over an average follow-up period of 98.07 \u00b1 45.6 months, 82 patients with brain AVMs underwent open microsurgical resection at the National Centre for Neurosurgery. Among them, 27 patients presented with seizures and had complete follow-up information, qualifying them for inclusion in this study. The participants had a mean age of 32.59 \u00b1 9.06 years, with 13 of them being women. The Spetzler\u2013Martin grading system was used to classify the AVMs: 6 patients had grade 1, 13 had grade 2, 7 had grade 3, and 1 had grade 4. More than half of the patients experienced generalized seizures. Microsurgical removal of the AVMs resulted in seizure remission for all patients. Only one patient experienced postoperative hemorrhage during the follow-up period. Additionally, one patient developed acute postoperative anemia, which resolved with a favorable outcome. Conclusions: Microsurgical resection of brain AVMs, when performed with careful patient selection, leads to a significant reduction in seizure activity. It is a safe and effective treatment option for symptomatic epilepsy associated with brain AVMs.<\/jats:p>","DOI":"10.3390\/medicina61050856","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T11:38:06Z","timestamp":1746531486000},"page":"856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Dynamics of Seizures After Microsurgical Treatment of Brain AVMs in Patients with Symptomatic Epilepsy: A Single-Center Experience over 10 Years"],"prefix":"10.3390","volume":"61","author":[{"given":"Yerbol","family":"Makhambetov","sequence":"first","affiliation":[{"name":"National Centre for Neurosurgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-9714","authenticated-orcid":false,"given":"Aiman","family":"Maidan","sequence":"additional","affiliation":[{"name":"Taraz City Multidisciplinary Hospital and Consulting and Diagnostic Center, Taraz 080000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0427-1751","authenticated-orcid":false,"given":"Iroda","family":"Mammadinova","sequence":"additional","affiliation":[{"name":"National Centre for Neurosurgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karashash","family":"Menlibayeva","sequence":"additional","affiliation":[{"name":"National Centre for Neurosurgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baurzhan","family":"Kunakbayev","sequence":"additional","affiliation":[{"name":"National Centre for Neurosurgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serik","family":"Dyussembaev","sequence":"additional","affiliation":[{"name":"National Centre for Neurosurgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-9315","authenticated-orcid":false,"given":"Nurtay","family":"Nurakay","sequence":"additional","affiliation":[{"name":"National Centre for Neurosurgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nursultan","family":"Makhambetov","sequence":"additional","affiliation":[{"name":"National Centre for Neurosurgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aigul","family":"Almabayeva","sequence":"additional","affiliation":[{"name":"Anatomy Faculty, Astana Medical University, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-7980","authenticated-orcid":false,"given":"Chingiz","family":"Nurimanov","sequence":"additional","affiliation":[{"name":"National Centre for Neurosurgery, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1227\/00006123-198503000-00026","article-title":"Natural history of intracranial vascular malformations: A review","volume":"16","author":"Wilkins","year":"1985","journal-title":"Neurosurgery"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ross, J., and Al-Shahi Salman, R. 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