{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:49:33Z","timestamp":1792799373828,"version":"4.5.0"},"reference-count":23,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Sepsis is a leading cause of morbidity and mortality worldwide, yet data from Central and Eastern Europe remain scarce. Our study aims to address the scarcity of information regarding the characteristics and mortality rates of patients with sepsis by reporting recent data from one of the largest emergency centers in Romania over an 18-year period (2007\u20132024). Materials and Methods: A retrospective analysis was conducted on 12,089 adult patients diagnosed with sepsis at the University Emergency Hospital of Bucharest. Patients were identified using International Classification of Diseases (ICD-10) codes and free-text diagnosis. Demographic and clinical data were extracted, including comorbidities, interventions, and mortality outcomes. Associations between comorbidities and in-hospital mortality were assessed using odds ratios (ORs) and 95% confidence intervals (CIs). Results: The study population had a mean age of 68.7 years, with a slight predominance of males (50.9%). In-hospital mortality was 53.9%, and 30-day mortality reached 85.1%. The most common comorbidities were diabetes (27.2%), chronic kidney disease (14.0%), and cancer (12.9%). Pneumonia (OR = 2.08, 95% CI: 1.89\u20132.28), cirrhosis (OR = 1.69, 95% CI: 1.40\u20132.03), and chronic obstructive pulmonary disease (OR = 1.50, 95% CI: 1.27\u20131.77) were strong predictors of mortality, while diabetes was associated with a slightly lower risk (OR = 0.90, 95% CI: 0.83\u20130.97). Conclusions: Sepsis-related mortality in Romania is higher than reported in Western Europe and North America, resembling trends in resource-limited settings. Targeted early recognition, antimicrobial stewardship, and improved intensive care units (ICU) resource allocation are crucial for reducing mortality. Multicenter studies and microbiological analyses are needed to further understand sepsis outcomes in this region.<\/jats:p>","DOI":"10.3390\/medicina61050864","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T06:47:15Z","timestamp":1746686835000},"page":"864","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sepsis Burden in a Major Romanian Emergency Center\u2014An 18-Year Retrospective Analysis of Mortality and Risk Factors"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2575-8646","authenticated-orcid":false,"given":"Florentina","family":"Mu\u0219at","sequence":"first","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, Faculty of Medicine, General Surgery Department, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Nicolae","family":"P\u0103duraru","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, Faculty of Medicine, General Surgery Department, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bolocan","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, Faculty of Medicine, General Surgery Department, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5145-5404","authenticated-orcid":false,"given":"Cosmin-Alexandru","family":"Palc\u0103u","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, Faculty of Medicine, General Surgery Department, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9492-5679","authenticated-orcid":false,"given":"Andrei-Alexandru","family":"Bunea","sequence":"additional","affiliation":[{"name":"Department of Computer Science, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ion","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, Faculty of Medicine, General Surgery Department, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9053-0018","authenticated-orcid":false,"given":"Octavian","family":"Andronic","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, Faculty of Medicine, General Surgery Department, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania"},{"name":"Innovation and eHealth Center, Carol Davila University of Medicine and Pharmacy, 010451 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1056\/NEJMp1707170","article-title":"Recognizing Sepsis as a Global Health Priority\u2014A WHO Resolution","volume":"377","author":"Reinhart","year":"2017","journal-title":"N. 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