{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:52:37Z","timestamp":1787237557918,"version":"build-2736575974"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Despite their high prevalence, sarcopenia and sarcopenic obesity remain underdiagnosed worldwide, significantly impacting the health and quality of life of aging individuals. Due to their multifactorial nature, the current management strategies do not address their underlying pathogenesis. This systematic review aims to identify single-nucleotide polymorphisms (SNPs) associated with sarcopenia and\/or sarcopenic obesity in humans. Materials and Methods. This systematic literature review followed the \u201cPreferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)\u201d guidelines and the protocol registered in PROSPERO. Extensive research was performed in six databases (PubMed, Web of Science, Cochrane Library, Scopus, ScienceDirect, and SpringerLink) using keywords such as \u201csarcopenia\u201d, \u201csarcopenic obesity\u201d, \u201csingle nucleotide polymorphisms\u201d, \u201cSNPs\u201d, and \u201cgenetic variants\u201d. The Q-Genie and ROBINS-E tools were utilized to assess the quality of the included studies. Results: The final analysis included 12 studies, which were classified as good-quality according to the Q-Genie assessment and indicated a low to moderate risk of bias according to the ROBINS-E evaluation, collectively identifying 43 SNPs significantly associated with sarcopenia or sarcopenic obesity. Specifically, 24 SNPs were linked to sarcopenia, while 19 were associated with sarcopenic obesity. Conclusions: Understanding the implications of SNPs provides valuable insights into individual susceptibility and the variability observed across populations, potentially leading to more targeted and effective diagnostic and treatment strategies. Advancing clinical practice requires ongoing research into the genetic aspects of sarcopenia and sarcopenic obesity.<\/jats:p>","DOI":"10.3390\/medicina61050866","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T09:58:09Z","timestamp":1746698289000},"page":"866","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic Patterns Related with the Development and Progression of Sarcopenia and Sarcopenic Obesity: A Systematic Review"],"prefix":"10.3390","volume":"61","author":[{"given":"Andreea-Dalila","family":"Nedelcu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Doctoral School, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"},{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea-Bianca","family":"Uzun","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Doctoral School, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"},{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-6443","authenticated-orcid":false,"given":"Viorela-Mihaela","family":"Ciortea","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Irsay","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana-Elena","family":"Stanciu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Doctoral School, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"},{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Marcel","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florina Ligia","family":"Popa","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Department, Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, Victoriei Blvd., 550024 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-3160","authenticated-orcid":false,"given":"M\u0103d\u0103lina-Gabriela","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Doctoral School, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"},{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constanta, 1 University Alley, Campus-Corp B, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Urzi, F., Pokorny, B., and Buzan, E. 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