{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T21:12:30Z","timestamp":1786569150508,"version":"build-2736575974"},"reference-count":85,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Considered one of the most severe types of trauma with a high impact upon patient survival, burns are the leading cause of disability-adjusted life-years (DALYs), and are responsible for high morbidity, prolonged hospitalization, disfigurement and social stigma. Of particular interest are injuries that affect the functional areas: face, neck, hand and fingers, joints, feet and soles and perineum. Burns to these regions highly influence the day-to-day activities of patients due to the formation of vicious scars and contractures, which may affect both quality of life and functional capacity. One of the primary challenges in the management of burn patients is the effective coverage of tissue defects resulting from such injuries. Cases that have a large area of burned surface also have a limited amount of total available skin. As such, the importance of skin substitutes increases, particularly in the treatment of these areas. Skin substitutes are widely utilized in plastic surgery due to their ability to promote wound healing by providing an extracellular matrix. Consequently, ongoing research has focused on developing skin substitutes that can serve as alternatives to autografts, addressing the challenges associated with large-scale tissue loss. This article aims to present and compare the most used skin substitutes, highlighting their respective advantages and limitations. This topic continues to be a subject of significant debate, as an ideal substitute has yet to be created. The cost\u2013efficiency ratio is a practical consideration that must be tailored to each specific medical system. The available data in the literature usually present general guidelines, not rules, and as such, they need to be adapted to each patient\u2019s necessities.<\/jats:p>","DOI":"10.3390\/medicina61060947","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:32:37Z","timestamp":1747888357000},"page":"947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Skin Substitutes in the Therapeutical Management of Burns Affecting Functional Areas"],"prefix":"10.3390","volume":"61","author":[{"given":"Matei","family":"Iordache","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery and Reconstructive Microsurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy Bucharest, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Avram","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Reconstructive Microsurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy Bucharest, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioan","family":"Lascar","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Reconstructive Microsurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy Bucharest, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Frunza","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Reconstructive Microsurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy Bucharest, 010825 Bucharest, Romania"},{"name":"Burn Centre, Emergency Clinical Hospital of Bucharest, 014461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2024, August 13). 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