{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:16:24Z","timestamp":1791195384027,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Backgrounds and Objectives: In this study, we aimed to assess preoperative frailty among hospitalized patients over 60 undergoing colorectal cancer surgery. We investigated the impacts of frailty and sarcopenia on postoperative recovery, complications, and discharge time, while also identifying a cost-effective, bedside-accessible USG parameter for diagnosing sarcopenia among patients assessed using the \u201cSonographic Thigh Adjustment Ratio\u201d method. Materials and Methods: In this prospective study, we investigated the impacts of frailty and sarcopenia on the postoperative outcomes of 42 geriatric patients (with American Society of Anesthesiologists (ASA) scores of I\u2013III) undergoing colorectal cancer surgery under general anesthesia. Frailty was assessed using the FRAIL scale, and sarcopenia was evaluated using the STAR (sonographic thigh adjustment ratio). Ultrasonographic measurements of rectus femoris and vastus intermedius muscle thicknesses were taken, and thigh lengths (TLs) were recorded. Ratios, including rectus femoris thickness\/TL (RFT\/TL), vastus intermedius thickness\/TL (VIT\/TL), and total muscle thickness\/TL (TMT\/TL), were calculated. Postoperative anesthesia recovery was monitored using the Modified Aldrete Score, indicating the time until discharge from the recovery unit. Complications were classified using the Clavien\u2013Dindo system, and hospital discharge times were noted. Results: We observed significant differences between frailty status and ASA scores, as well as between age and frailty status. Muscle thickness significantly differed between the frail and pre-frail patients. Among the sarcopenic patients, age differences were significant. In men, VIT\/TL was significantly correlated with sarcopenia diagnosis, whereas, in women, RFT\/TL, VIT\/TL, and TMT\/TL were all correlated with sarcopenia. Conclusions: Based on our results, we conclude that VIT\/TL measurement can serve as a predictive marker for preoperative sarcopenia, optimizing patient health before surgery.<\/jats:p>","DOI":"10.3390\/medicina61060969","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T20:39:36Z","timestamp":1748205576000},"page":"969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Investigation into the Effects of Frailty and Sarcopenia on Postoperative Anesthesia Recovery and Complications Among Geriatric Patients Undergoing Colorectal Malignancy Surgery"],"prefix":"10.3390","volume":"61","author":[{"given":"R\u00fc\u015ft\u00fc","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Faculty of Medicine, Eski\u015fehir Osmangazi University, Eski\u015fehir 26040, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6847-1720","authenticated-orcid":false,"given":"Ferda","family":"Yaman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Faculty of Medicine, Eski\u015fehir Osmangazi University, Eski\u015fehir 26040, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.7326\/0003-4819-144-8-200604180-00009","article-title":"Preoperative Pulmonary Risk Stratification for Noncardiothoracic Surgery: Systematic Review for the American College of Physicians","volume":"144","author":"Smetana","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.7326\/0003-4819-134-8-200104170-00008","article-title":"Impact of Age on Perioperative Complications and Length of Stay in Patients Undergoing Noncardiac Surgery","volume":"134","author":"Polanczyk","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jss.2020.06.043","article-title":"Thigh Ultrasound Used to Identify Frail Elderly Patients with Sarcopenia Undergoing Surgery: A Pilot Study","volume":"256","author":"Salim","year":"2020","journal-title":"J. Surg. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S1470-2045(03)01248-8","article-title":"Training and quality assurance for rectal cancer: 20 years of data is enough","volume":"4","author":"Quirke","year":"2003","journal-title":"Lancet Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40200-017-0302-x","article-title":"Prevalence of sarcopenia in the world: A systematic review and meta- analysis of general population studies","volume":"16","author":"Shafiee","year":"2017","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_7","first-page":"2767232","article-title":"Bedside Ultrasound Measurement of Rectus Femoris: A Tutorial for the Nutrition Support Clinician","volume":"2017","author":"Zepeda","year":"2017","journal-title":"J. Nutr. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12877-016-0349-4","article-title":"Sarcopenia in daily practice: Assessment and management","volume":"16","author":"Beaudart","year":"2016","journal-title":"BMC Geriatr."},{"key":"ref_9","first-page":"36","article-title":"MRI safety: Everyone\u2019s job","volume":"23","author":"Kerr","year":"2001","journal-title":"Radiol. Manag."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/PHM.0000000000001352","article-title":"Ultrasound Imaging and Rehabilitation of Muscle Disorders","volume":"99","author":"Kara","year":"2020","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wang, J.C., Wu, W.T., Chang, K.V., Chen, L.R., Chi, S.Y., Kara, M., and \u00d6z\u00e7akar, L. (2021). Ultrasound Imaging for the Diagnosis and Evaluation of Sarcopenia: An Umbrella Review. Life, 12.","DOI":"10.3390\/life12010009"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s11357-013-9539-6","article-title":"Prevalence of site-specific thigh sarcopenia in Japanese men and women","volume":"36","author":"Abe","year":"2014","journal-title":"Age"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"jrm00209","DOI":"10.2340\/16501977-2851","article-title":"Diagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM","volume":"53","author":"Kara","year":"2021","journal-title":"J. Rehabil. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/PHM.0000000000001439","article-title":"STAR\u2014Sonographic Thigh Adjustment Ratio","volume":"99","author":"Kara","year":"2020","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1532-5415.2009.02137.x","article-title":"A Comparison of Frailty Indexes for the Prediction of Falls, Disability, Fractures, and Mortality in Older Men","volume":"57","author":"Ensrud","year":"2009","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cger.2010.08.009","article-title":"The Frailty Syndrome: Definition and Natural History","volume":"27","author":"Xue","year":"2011","journal-title":"Clin. Geriatr. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in Older Adults: Evidence for a Phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_19","first-page":"1","article-title":"Steering Committee, Canadian Initiative on Frailty and Aging. Models, definitions, and criteria of frailty","volume":"15","author":"Hogan","year":"2003","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"650","DOI":"10.7326\/M16-0652","article-title":"Preoperative Frailty Assessment and Outcomes at 6 Months or Later in Older Adults Undergoing Cardiac Surgical Procedures","volume":"165","author":"Kim","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/SLA.0000000000002967","article-title":"Frailty as a Predictor of Death or New Disability After Surgery","volume":"271","author":"McIsaac","year":"2020","journal-title":"Ann. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jamda.2007.11.005","article-title":"Frailty: Toward a Clinical Definition","volume":"9","author":"Rolland","year":"2008","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_23","unstructured":"(2024, November 20). Available online: https:\/\/www.medcalc.org\/."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s43587-020-00017-z","article-title":"The physical frailty syndrome as a transition from homeostatic symphony to cacophony","volume":"1","author":"Fried","year":"2021","journal-title":"Nat. Aging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2468-2667(18)30091-4","article-title":"Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: A prospective analysis of 493 737 UK Biobank participants","volume":"3","author":"Hanlon","year":"2018","journal-title":"Lancet Public Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e198398","DOI":"10.1001\/jamanetworkopen.2019.8398","article-title":"Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults","volume":"2","author":"Chin","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s12603-019-1179-9","article-title":"Prevalence and Risk Factors for Frailty Among Community-Dwelling Older People in China: A Systematic Review and Meta-Analysis","volume":"23","author":"He","year":"2019","journal-title":"J. Nutr. Health Aging"},{"key":"ref_28","first-page":"611","article-title":"Comparison of the modified 5-item frailty index with the American society of anesthesiologists classification and Charlson age comorbidity index for predicting postoperative outcomes in geriatric patients: A prospective observational study","volume":"25","author":"Geyik","year":"2022","journal-title":"Turk. J. Geriatr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1186\/s12877-024-05008-y","article-title":"Role of muscle ultrasound in frailty assessment in older adults with type 2 diabetes mellitus","volume":"24","author":"Karaduman","year":"2024","journal-title":"BMC Geriatr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"154930","DOI":"10.1016\/j.jcrc.2024.154930","article-title":"Quadriceps Muscle Layer Thickness and its association with frailty in critically ill patients: A prospective observational study","volume":"85","author":"Sundarsingh","year":"2025","journal-title":"J. Crit. Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12882-022-03043-8","article-title":"Ultrasound quadriceps muscle thickness is variably associated with frailty in haemodialysis recipients","volume":"24","author":"Anderson","year":"2023","journal-title":"BMC Nephrol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jamcollsurg.2010.01.028","article-title":"Frailty as a Predictor of Surgical Outcomes in Older Patients","volume":"210","author":"Makary","year":"2010","journal-title":"J. Am. Coll. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1308\/rcsann.2016.0048","article-title":"Systematic review and meta-analysis of the association between frailty and outcome in surgical patients","volume":"98","author":"Oakland","year":"2016","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1089\/jwh.2011.2992","article-title":"Gender differences in colorectal cancer incidence in the United States, 1975\u20132006","volume":"21","author":"Abotchie","year":"2012","journal-title":"J. Women\u2019s Health"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/j.clnu.2018.12.025","article-title":"Sarcopenia as a predictor of poor surgical and oncologic outcomes after abdominal surgery for digestive tract cancer: A prospective cohort study","volume":"38","author":"Zhang","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s00384-021-03839-4","article-title":"Sarcopenia predicts worse postoperative outcomes and decreased survival rates in patients with colorectal cancer: A systematic review and meta-analysis","volume":"36","year":"2021","journal-title":"Int. J. Color. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/DCR.0000000000001633","article-title":"Sarcopenia, as Assessed by Psoas Cross-Sectional Area, Is Predictive of Adverse Postoperative Outcomes in Patients Undergoing Colorectal Cancer Surgery","volume":"63","author":"Richards","year":"2020","journal-title":"Dis. Colon Rectum"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/6\/969\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:39:24Z","timestamp":1760031564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/6\/969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["medicina61060969"],"URL":"https:\/\/doi.org\/10.3390\/medicina61060969","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]}}}