{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:08:16Z","timestamp":1771636096203,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>(1) Background and Objectives: Endometriosis is defined as the presence of endometrial glands and stroma outside the uterine cavity. It affects 5\u201315% of women of reproductive age. Ovarian cancer develops in approximately 1% of patients with endometriosis. Prediction of those with endometriosis who will develop ovarian cancer is among the current research topics. (2) Materials and Methods: With this study, we aimed to reveal the role of miRNA 200b and miRNA 21 in endometriosis-associated ovarian carcinoma (EAOC). Thirteen patients diagnosed as having EAOC between 2015 and 2023 were included, with their endometriosis and eutopic endometrium tissues (Group 3: 13 patients, 39 tissue samples). Two separate groups were then detected to compare with these cases: Group 2 composed of tuba-ovarian endometriosis with its eutopic endometrium (10 patients, 20 tissue samples) and Group 1 composed of eutopic endometrium only (10 patients, 10 tissue samples). The foci marked on H&amp;E sections were determined from the area on the relevant paraffin blocks and small tissue samples were taken in tubes to be studied with real-time PCR. (3) Results: No significant difference was detected for miRNA 21 and miRNA 200b expression levels among eutopic endometrium, endometriosis, and cancer foci in Group 3. However, miRNA 21 and miRNA 200b expression levels in the eutopic endometrial tissue of cases with ovarian cancer were significantly higher than in the eutopic endometrial tissues of cases with (Group 2) and without endometriosis (Group 1). (4) Conclusions: This study suggests that increased miRNA 200b and miRNA 21 expression levels detected in eutopic endometrial tissue of patients with endometriosis may contribute to identifying cases that may develop EAOC.<\/jats:p>","DOI":"10.3390\/medicina61061035","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T03:57:34Z","timestamp":1749009454000},"page":"1035","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of MicroRNA 21 and MicroRNA 200b Expression on Carcinogenesis in Endometriosis-Associated Ovarian Cancers and Relationship with Clinicopathological Parameters"],"prefix":"10.3390","volume":"61","author":[{"given":"Esra Canan Kelten","family":"Talu","sequence":"first","affiliation":[{"name":"Department of Pathology, Tepecik Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir 35540, T\u00fcrkiye"},{"name":"Department of Molecular Pathology, Faculty of Medicine, Institute of Health Sciences, DokuzEylul University, Izmir 35410, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine \u00c7a\u011fnur","family":"Uluku\u015f","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Ata\u015fehir Hospital, Istanbul 34750, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, DokuzEylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3516-952X","authenticated-orcid":false,"given":"Merih G\u00fcray","family":"Durak","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, DokuzEylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Bayramo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, DokuzEylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikmet Tun\u00e7","family":"Timur","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, DokuzEylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sefa","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, DokuzEylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sefai Merve","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Basic Oncology, Institute of Oncology, DokuzEylul University, Izmir 35330, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-5565","authenticated-orcid":false,"given":"Safiye","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Faculty of Medicine, Institute of Health Sciences, DokuzEylul University, Izmir 35410, T\u00fcrkiye"},{"name":"Department of Pathology, Faculty of Medicine, DokuzEylul University, Izmir 35340, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref_1","first-page":"401","article-title":"MikroRNA\u2019 lar ve mikroRNA\u2019 lar\u0131n biyobelirte\u00e7 olarak endometriozis ve endometriozis ili\u015fkili epitelyal over kanserlerindeki rol\u00fc","volume":"35","author":"Talu","year":"2021","journal-title":"Dokuz Eyl\u00fcl \u00dcniversitesi T\u0131p Fak\u00fcltesi Derg."},{"key":"ref_2","unstructured":"WHO Classification of Tumours (2020). 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