{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:10:30Z","timestamp":1787771430258,"version":"build-2784847793"},"reference-count":117,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Urinary incontinence is characterized by the involuntary leakage of urine. The primary cause of stress urinary incontinence in women is the weakening of the pelvic floor muscles. Stress urinary incontinence (SUI) is a significant global health problem that impacts mainly middle-aged women, with a severe impact on their quality of life. Traditional diagnostic methods and treatments often fail, although technological innovations have improved diagnostic accuracy, such as specific questionnaires or transperineal ultrasound. While medical therapies and surgical procedures are continuously being developed, controversies about the correct choices regarding diagnostic and treatment methods continue to exist. The aim of our review was to identify the innovative diagnostic tools and effective treatment procedures for SUI. A narrative review was conducted due to the heterogeneity of the studies. New methods for diagnosis and treatment have gained ground, and we have covered them in our review; however, the field continues to expand. A personalized approach to diagnosis is also a requirement because of the limitations of conventional urodynamic studies, and we emphasize the importance of such personalization in enhancing clinical decision making. Future medical strategies that combine both preventive and therapeutic care are desirable. Newer technologies were brought to light in this review, including stem cell therapy and laser therapy.<\/jats:p>","DOI":"10.3390\/medicina61071272","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T08:04:41Z","timestamp":1752566681000},"page":"1272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Innovations in Stress Urinary Incontinence: A Narrative Review"],"prefix":"10.3390","volume":"61","author":[{"given":"Tamas","family":"Szabo","sequence":"first","affiliation":[{"name":"Doctoral School, University of Medicine, Pharmacy, Sciences and Technology \u201cGeorge Emil Palade\u201d, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-6353","authenticated-orcid":false,"given":"Melinda-Ildiko","family":"Mitranovici","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liviu","family":"Moraru","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine, Pharmacy, Sciences and Technology \u201cGeorge Emil Palade\u201d, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5944-3522","authenticated-orcid":false,"given":"Dan","family":"Costachescu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Georgiana","family":"Caravia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-2714","authenticated-orcid":false,"given":"Elena","family":"Bernad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Center for Laparoscopy, Laparoscopic Surgery, In Vitro Fertilization, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"},{"name":"Clinic of Obstetrics and Gynecology, \u201cPius Brinzeu\u201d County Clinical Emergency Hospital, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-4911","authenticated-orcid":false,"given":"Viviana","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Cardiology \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6684-1759","authenticated-orcid":false,"given":"Adrian","family":"Apostol","sequence":"additional","affiliation":[{"name":"Department of Cardiology \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Faculty of Electrical Engineering, Technical University, George Baritiu Street, 400394 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian","family":"Puscasiu","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine, Pharmacy, Sciences and Technology \u201cGeorge Emil Palade\u201d, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Shaker, P., Roshani, Z., Timajchi, E., Sharifi, Z., Goli, S.N., Broumand, B., and Shafiee, M.A. (2025). The Role of Urinary Microbiome Analysis in the Diagnostic Approach and Management of Urinary Incontinence: A Systematic Review. Life, 15.","DOI":"10.3390\/life15020309"},{"key":"ref_2","first-page":"193","article-title":"Treating and managing urinary incontinence: Evolving and potential multicomponent medical and lifestyle interventions","volume":"15","author":"Taithongchai","year":"2023","journal-title":"Res. Rep. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s00192-017-3339-y","article-title":"Innovative treatment modalities for urinary incontinence: A European survey identifying experience and attitude of healthcare providers","volume":"28","author":"Kastelein","year":"2017","journal-title":"Int. Urogynecology J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejogrb.2024.07.064","article-title":"Bridging present and future: A narrative review and visionary outlook on innovative solutions for the diagnosis and treatment of urinary incontinence","volume":"301","author":"Rotem","year":"2024","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_5","unstructured":"Lugo, T., Leslie, S.W., Mikes, B.A., and Riggs, J. (2024). Stress Urinary Incontinence. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_6","first-page":"1","article-title":"Pelvic floor ultrasonography: An update","volume":"65","author":"Shek","year":"2013","journal-title":"Minerva Ginecol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/aogs.14373","article-title":"Medical innovations are driven by controversies","volume":"101","author":"Acharya","year":"2022","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Mitulovi\u0107, G., Mohr, T., and Koch, M. (2019). Stress Urinary Incontinence: A Proteomics Overview. Lower Urinary Tract Dysfunction-From Evidence to Clinical Practice, IntechOpen.","DOI":"10.5772\/intechopen.87178"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Santoro, G.A., Colangelo, A.C., Pelizzo, P., Cian, R., and Zanus, G. (2022). Imaging modalities for pelvic floor disorders. Ann. Laparosc. Endosc. Surg., 7.","DOI":"10.21037\/ales-21-44"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00192-014-2489-4","article-title":"Clinical risk factors and urodynamic predictors prior to surgical treatment for stress urinary incontinence: A narrative review","volume":"26","author":"Bing","year":"2015","journal-title":"Int. Urogynecology J."},{"key":"ref_11","first-page":"16","article-title":"American urogynecologic society systematic review: The impact of weight loss intervention on lower urinary tract symptoms and urinary incontinence in overweight and obese women","volume":"26","author":"Yazdany","year":"2020","journal-title":"Urogynecology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1007\/s00192-021-04950-4","article-title":"Urodynamic and questionnaire findings in urinary incontinent women with and without diabetes. Data from a health study","volume":"32","author":"Andersen","year":"2021","journal-title":"Int. Urogynecology J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/01.SPV.0000056863.70573.B0","article-title":"Pelvic floor dysfunction: The need for a multidisciplinary team approach","volume":"9","author":"Davis","year":"2003","journal-title":"J. Pelvic Med. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1002\/nau.25445","article-title":"Recommendations of the SUFU\/AUGS\/ICS Female Stress Urinary Incontinence Surgical Publication Working Group: A common standard minimum data set for the literature","volume":"43","author":"Rovner","year":"2024","journal-title":"Neurourol. Urodyn."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ajog.2009.08.018","article-title":"Pelvic floor ultrasound: A review","volume":"202","author":"Dietz","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s001920200069","article-title":"Pelvic floor dysfunction management practice patterns: A survey of members of the international urogynecological association","volume":"13","author":"Davila","year":"2002","journal-title":"Int. Urogynecology J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Santoro, G.A., Wieczorek, A.P., Wo\u017aniak, M.M., Alshiek, J., Shoebeiri, A., and Sultan, A.H. (2021). Integrated Imaging Approach to Pelvic Organ Prolapse. Pelvic Floor Disorders: A Multidisciplinary Textbook, Springer.","DOI":"10.1007\/978-3-030-40862-6"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bshawri, M.A., Alnami, M.A.A., Jumah, L.A.A., Alhawaswi, K.M., Almajid, H.A., Alshammari, S.M., Alghamdi, K.B.M., Walanshira, J.M.A., Al-Halil, M.A., and Alojayan, G.E.A. (2024). A Multidisciplinary Approach to Managing Pelvic Floor Disorders: The Roles of Gynecology, Nursing, Health Education, Medical Physics, Laboratory Specialist, and Health Information Systems. J. Ecohumanism, 3.","DOI":"10.62754\/joe.v3i8.6551"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Alshiek, J., and Shobeiri, S.A. (2018). Innovation Breeds Innovation: How Pelvic Floor Ultrasound Filled the Diagnostic Gap for Vaginal Mesh Kit Complications. The Innovation and Evolution of Medical Devices: Vaginal Mesh Kits, Springer International Publishing.","DOI":"10.1007\/978-3-319-97073-8"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.eururo.2024.12.017","article-title":"Prevalence, Diagnosis, and Management of Stress Urinary Incontinence in Women: A Collaborative Review","volume":"87","author":"Moris","year":"2025","journal-title":"Eur. Urol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.maturitas.2017.12.008","article-title":"Management of female stress urinary incontinence: A care pathway and update","volume":"109","author":"Capobianco","year":"2018","journal-title":"Maturitas"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Winiarek, K., Michalska, M., Wardyn, W., Guzowski, C., Murawska, J., Ziemi\u0144ska, D., Burczyk, R., and K\u0119dziora-Kornatowska, K. (2024). Cutting-Edge Approaches in Urinary Incontinence Treatment: A Comprehensive Review. Qual. Sport, 31.","DOI":"10.12775\/QS.2024.31.55898"},{"key":"ref_23","first-page":"259","article-title":"Duloxetine in the treatment of stress urinary incontinence","volume":"1","author":"Jost","year":"2005","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Okui, N. (2024). Innovative decision making tools using discrete mathematics for stress urinary incontinence treatment. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-60407-w"},{"key":"ref_25","unstructured":"Chee, S.C.S. (2022, January 23\u201326). Concurrent Session-6 Urogynecology: Preventive Urogynecology: Where Are We Now: Urinary Incontinence Current Concepts of Prevention. Proceedings of the 27th Asia and Oceania Federation of Obstetrics and Gynecology Congress, Bali, Indonesia."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.34057\/PPj.2022.41.01.2021-8-2","article-title":"The multidisciplinary approach to pelvic floor diseases: An Italian survey","volume":"41","author":"Losacco","year":"2022","journal-title":"Pelviperineology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/JU.0000000000003435","article-title":"Updates to surgical treatment of female stress urinary incontinence (SUI): AUA\/SUFU guideline","volume":"209","author":"Kobashi","year":"2023","journal-title":"J. Urol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Li, M.-W., Tsai, Y.-C., Yang, S.S.-D., Pong, Y.-H., Tsai, Y.-T., and Tsai, V.F.-S. (2025). The Evolution of Uroflowmetry and Bladder Diary and the Emerging Trend of Using Home Devices From Hospital to Home. Interact. J. Med. Res., 14.","DOI":"10.2196\/66694"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5603\/GP.a2021.0256","article-title":"The Urogynecology Section of the Polish Society of Gynecologists and Obstetricians Guideline for the diagnostic assessment of stress urinary incontinence in women","volume":"94","author":"Wlazlak","year":"2023","journal-title":"Ginekol. Polska"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1001\/jama.299.12.1446","article-title":"What type of urinary incontinence does this woman have?","volume":"299","author":"Tannenbaum","year":"2008","journal-title":"JAMA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00192-008-0742-4","article-title":"Australian pelvic floor questionnaire: A validated interviewer-administered pelvic floor questionnaire for routine clinic and research","volume":"20","author":"Baessler","year":"2009","journal-title":"Int. Urogynecology J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00192-022-05398-w","article-title":"Current state of bladder diary: A survey and review of the literature","volume":"34","author":"Mehta","year":"2023","journal-title":"Int. Urogynecology J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1007\/s00192-024-05934-w","article-title":"Instruments Used for the Assessment of SUI Severity in Urogynecologic Surgical Trials: A Scoping Review","volume":"35","author":"Mikos","year":"2024","journal-title":"Int. Urogynecology J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00192-023-05695-y","article-title":"Pilot Study of a Novel Online Comprehensive Pelvic Floor Program for Urinary Incontinence in Women","volume":"35","author":"Chen","year":"2024","journal-title":"Int. Urogynecology J."},{"key":"ref_35","first-page":"1","article-title":"Measurement of the Vaginal Pressure Profile with the Femfit\u00ae and Leakage Events Using a Newly Developed Pad Test during Selected Sports Activities: A Pilot Study","volume":"36","author":"Bukova","year":"2025","journal-title":"Int. Urogynecology J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1080\/07399332.2023.2197861","article-title":"Urinary incontinence and quality of life in high-performance swimmers: An observational study","volume":"45","author":"Rubin","year":"2024","journal-title":"Health Care Women Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.36502\/2020\/ASJBCCR.6211","article-title":"Epidemiology analysis of pelvic floor medicine center in southern Israel using PFDI-20 and PISQ-12 quality of life questionnaires","volume":"3","author":"Levy","year":"2020","journal-title":"Asploro J. Biomed. Clin. Case Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1007\/s00192-013-2144-5","article-title":"Translation and psychometric evaluation of the Greek short forms of two condition-specific quality of life questionnaires for women with pelvic floor disorders: PFDI-20 and PFIQ-7","volume":"24","author":"Grigoriadis","year":"2013","journal-title":"Int. Urogynecology J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00404-023-07140-3","article-title":"Quality-of-life improvements in patients after various surgical treatments for pelvic organ prolapse","volume":"309","author":"Guan","year":"2024","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_40","first-page":"415","article-title":"The impact of stress urinary incontinence on sexual function and quality of life","volume":"177","author":"Palumbo","year":"2018","journal-title":"Gazz. Med. Ital. Arch. Sci. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/AOG.0000000000003648","article-title":"Effect of surgery for stress incontinence on female sexual function","volume":"135","author":"Clark","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1007\/s00404-024-07414-4","article-title":"Urodynamic insights: Exploring the relationship between detrusor overactivity and pelvic organ prolapse in women with urge incontinence","volume":"309","author":"Rotem","year":"2024","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Pietrus, M., Pity\u0144ski, K., Socha, M.W., Gawron, I., Biskupski-Brawura-Samaha, R., and Walig\u00f3ra, M. (2024). Enhanced non-invasive diagnosis of female urinary incontinence using static and functional transperineal ultrasonography. Diagnostics, 14.","DOI":"10.3390\/diagnostics14222549"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"De Vicari, D., Barba, M., Costa, C., Cola, A., and Frigerio, M. (2025). Assessment of Urethral Elasticity by Shear Wave Elastography: A Novel Parameter Bridging a Gap Between Hypermobility and ISD in Female Stress Urinary Incontinence. Bioengineering, 12.","DOI":"10.3390\/bioengineering12040373"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s00192-020-04483-2","article-title":"Prospective ultrasonographic follow-up of transvaginal lightweight meshes: A 1-year multicenter study","volume":"32","author":"Callewaert","year":"2021","journal-title":"Int. Urogynecology J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/mp.16810","article-title":"A feasibility study of three-dimensional ultrasound imaging of the vagina under distension","volume":"51","author":"Zhang","year":"2024","journal-title":"Med Phys."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Chen, Y.-C., and Kuo, H.-C. (2025). Integrating biomarker clustering for improved diagnosis of interstitial cystitis\/bladder pain syndrome: A review. Int. Urol. Nephrol., 1\u201310.","DOI":"10.1007\/s11255-025-04452-y"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Post, W.M., Widomska, J., Grens, H., Coenen, M.J.H., Martens, F.M.J., Janssen, D.A.W., IntHout, J., Poelmans, G., Oosterwijk, E., and Kluivers, K.B. (2022). Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063401"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.juro.2013.10.051","article-title":"Inflammatory and tissue remodeling urinary biomarkers before and after mid urethral sling surgery for stress urinary incontinence","volume":"191","author":"Chai","year":"2014","journal-title":"J. Urol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.juro.2017.01.037","article-title":"Urinary biomarkers in women with refractory urgency urinary incontinence randomized to sacral neuromodulation versus onabotulinumtoxina compared to controls","volume":"197","author":"Richter","year":"2017","journal-title":"J. Urol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00192-024-05821-4","article-title":"The Study of Microbiome of the Female Genital Area in Relation to Pelvic Floor Dysfunction: A Systematic Review","volume":"35","author":"Balaouras","year":"2024","journal-title":"Int. Urogynecology J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1007\/s11694-025-03112-0","article-title":"Antiproliferative and antibacterial activities of lactic acid bacteria-fermented pomegranate juice: Implications for colon cancer therapy","volume":"19","author":"Rajendran","year":"2025","journal-title":"J. Food Meas. Charact."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00192-019-04025-5","article-title":"Gene expression in stress urinary incontinence: A systematic review","volume":"31","author":"Isali","year":"2020","journal-title":"Int. Urogynecology J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00192-023-05671-6","article-title":"Recurrent urinary tract infection genetic risk: A systematic review and gene network analysis","volume":"35","author":"Isali","year":"2024","journal-title":"Int. Urogynecology J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.euf.2019.06.006","article-title":"Urinary biomarkers in overactive bladder: Revisiting the evidence in 2019","volume":"5","author":"Cruz","year":"2019","journal-title":"Eur. Urol. Focus"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12192-022-01278-w","article-title":"Mechanism of miR-34a in the metabolism of extracellular matrix in fibroblasts of stress urinary incontinence via Nampt-mediated autophagy","volume":"27","author":"Zhou","year":"2022","journal-title":"Cell Stress Chaperon"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/21655979.2021.2009417","article-title":"Nampt promotes fibroblast extracellular matrix degradation in stress urinary incontinence by inhibiting autophagy","volume":"13","author":"Zhang","year":"2022","journal-title":"Bioengineered"},{"key":"ref_58","first-page":"624","article-title":"miR-93-mediated collagen expression in stress urinary incontinence via calpain-2","volume":"17","author":"Yang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Futyma, K., Nowakowski, \u0141., Zi\u0119tek-Strobl, A., Kami\u0144ska, A., Taoussi, N., and Rechberger, T. (2020). Urine Proteomic Study in OAB Patients\u2014Preliminary Report. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051389"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Long, C.-Y., Lin, K.-L., Lee, Y.-C., Chuang, S.-M., Lu, J.-H., Wu, B.-N., Chueh, K.-S., Ker, C.-R., Shen, M.-C., and Juan, Y.-S. (2020). Therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-62471-4"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Zhang, J., Zhang, L., Wang, W., Wang, L., Liang, X., Wei, L., Hao, Q., Wang, L., and Liu, X. (2024). Heterogeneity in extracellular matrix and immune microenvironment of anterior vaginal wall revealed by single-cell sequencing in women with stress urinary incontinence. Exp. Cell Res., 442.","DOI":"10.1016\/j.yexcr.2024.114280"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Wang, L., Wang, Y., Xiang, Y., Ma, J., Zhang, H., Dai, J., Hou, Y., Yang, Y., Ma, J., and Li, H. (2021). An in vitro study on extracellular vesicles from adipose-derived mesenchymal stem cells in protecting stress urinary incontinence through MicroRNA-93\/F3 Axis. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.693977"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Sun, X., Zhu, H., Li, W., Zhao, L., Li, W., Li, X., Xie, Z., and Cao, Y. (2021). Small extracellular vesicles secreted by vaginal fibroblasts exert inhibitory effect in female stress urinary incontinence through regulating the function of fibroblasts. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0249977"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Liu, X., Li, T., Zhang, J., Lin, X., Wang, W., Fan, X., and Wang, L. (2023). Mesenchymal stem cell-based therapy for female stress urinary incontinence. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1007703"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4103\/jdmimsu.jdmimsu_627_23","article-title":"Impact of Artificial Intelligence and Machine Learning on Urological Practice","volume":"19","author":"Ali","year":"2024","journal-title":"J. Datta Meghe Inst. Med Sci. Univ."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00192-021-04859-y","article-title":"Artificial intelligence models derived from 2D transperineal ultrasound images in the clinical diagnosis of stress urinary incontinence","volume":"33","author":"Zhang","year":"2022","journal-title":"Int. Urogynecology J."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Egorov, V. (2024). Digital Twin of the Female Pelvic Floor. Open J. Obstet. Gynecol., 14.","DOI":"10.4236\/ojog.2024.1411138"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Mahapatra, C. (2025). Artificial intelligence for diagnosing bladder pathophysiology: An updated review and future prospects. Bladder, 12.","DOI":"10.14440\/bladder.2024.0054"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/SPV.0000000000001246","article-title":"Contemporary Clinical Research in the Management of Pelvic Organ Prolapse in the United States: A Systematic Review","volume":"28","author":"Sandozi","year":"2022","journal-title":"Urogynecology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00192-021-04937-1","article-title":"Effectiveness and safety of bulking agents versus surgical methods in women with stress urinary incontinence: A systematic review and meta-analysis","volume":"33","author":"Pivazyan","year":"2022","journal-title":"Int. Urogynecology J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/453059","article-title":"New Advances in Urogynecology","volume":"2012","author":"Lowenstein","year":"2011","journal-title":"Obstet. Gynecol. Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/asj\/sjab174","article-title":"Transcutaneous temperature-controlled radiofrequency treatment: Improvement in female genital appearance, sexual dysfunction, and stress urinary incontinence","volume":"41","author":"Desai","year":"2021","journal-title":"Aesthetic Surg. J."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Brasil, C., Teles, A., Lemos, N., Basto Brito, M., Liony, C., Matos, J.C., D\u00f3ria, M., Leony, J.C., Lemos, L., and Campos, R. (2024). Radiofrequency in the Treatment of Urinary Incontinence of Female Stress: A Pilot Randomized Clinical Trial, ICS.","DOI":"10.21203\/rs.3.rs-3888375\/v1"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Razzaghi, M., Asghari-Azghan, A., Montazeri, S., Razzaghi, Z., Mazloomfard, M.M., and Vafaee, R. (2021). Intravaginal pulsed contractile radiofrequency for stress urinary incontinence treatment; A safety study. J. Lasers Med Sci., 12.","DOI":"10.34172\/jlms.2021.56"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ogc.2021.05.006","article-title":"Update in transvaginal grafts: The role of lightweight meshes, biologics, and hybrid grafts in pelvic organ prolapse surgery","volume":"48","author":"Tailor","year":"2021","journal-title":"Obstet. Gynecol. Clin."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00192-020-04363-9","article-title":"Stress urinary incontinence after transvaginal mesh surgery for anterior and apical prolapse: Preoperative risk factors","volume":"32","author":"Bideau","year":"2021","journal-title":"Int. Urogynecology J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1007\/s12221-023-00299-1","article-title":"Anti-infective Knitted Surgical Mesh for Stress Urinary Incontinence Applications: Synthesis, Characterization, and Investigation of Its In Vitro Biocompatibility","volume":"24","author":"Bozkaya","year":"2023","journal-title":"Fibers Polym."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00192-022-05435-8","article-title":"Establishment and initial implementation of the Australasian Pelvic Floor Procedure Registry","volume":"34","author":"Jayasinghe","year":"2023","journal-title":"Int. Urogynecology J."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Billone, V., Gullo, G., Perino, G., Catania, E., Cucinella, G., Ganduscio, S., Vassiliadis, A., and Zaami, S. (2024). Robotic versus Mini-Laparoscopic Colposacropexy to Treat Pelvic Organ Prolapse: A Retrospective Observational Cohort Study and a Medicolegal Perspective. J. Clin. Med., 13.","DOI":"10.3390\/jcm13164802"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Capobianco, G., Cherchi, P.L., and Dessole, S. (2019). Management of Female Stress Urinary Incontinence. Postmenopausal Diseases and Disorders, Springer International Publishing.","DOI":"10.1007\/978-3-030-13936-0_9"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1002\/sctm.19-0431","article-title":"Two phase I\/II clinical trials for the treatment of urinary incontinence with autologous mesenchymal stem cells","volume":"9","author":"Bravo","year":"2020","journal-title":"STEM Cells Transl. Med."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Culmone, S., Speciale, P., Guastella, E., Puglisi, T., Cucinella, G., Piazza, F., Morreale, C., Buzzaccarini, G., and Gullo, G. (2022). Sacral neuromodulation for refractory lower urinary tract dysfunctions: A single-center retrospective cohort study. Ital. J. Gynaecol. Obstet., 34.","DOI":"10.36129\/jog.2022.61"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s00192-019-04204-4","article-title":"The safety and efficacy of CO2 laser in the treatment of stress urinary incontinence","volume":"31","author":"Dabaja","year":"2020","journal-title":"Int. Urogynecology J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s10103-017-2170-5","article-title":"Non-ablative erbium YAG laser for the treatment of type III stress urinary incontinence (intrinsic sphincter deficiency)","volume":"32","author":"Gaspar","year":"2017","journal-title":"Lasers Med Sci."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Ruffolo, A.F., Braga, A., Torella, M., Frigerio, M., Cimmino, C., De Rosa, A., Sorice, P., Castronovo, F., Salvatore, S., and Serati, M. (2022). Vaginal laser therapy for female stress urinary incontinence: New solutions for a well-known issue\u2014A concise review. Medicina, 58.","DOI":"10.3390\/medicina58040512"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Okui, N. (2024). The treatment selection for a 36-Year-Old woman with stress urinary incontinence using a discrete mathematical approach: A case report. Cureus, 16.","DOI":"10.7759\/cureus.61314"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Lin, K.-L., Chueh, K.-S., Lu, J.-H., Chuang, S.-M., Wu, B.-N., Lee, Y.-C., Wu, Y.-H., Shen, M.-C., Sun, T.-W., and Long, C.-Y. (2021). Low Intensity extracorporeal shock wave therapy as a novel treatment for stress urinary incontinence: A randomized-controlled clinical study. Medicina, 57.","DOI":"10.21203\/rs.3.rs-414140\/v1"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"187.e1","DOI":"10.1016\/j.urology.2020.03.035","article-title":"Delayed treatment with low-intensity extracorporeal shock wave therapy in an irreversible rat model of stress urinary incontinence","volume":"141","author":"Zhang","year":"2020","journal-title":"Urology"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Wang, X.-X., Zhang, L., and Lu, Y. (2023). Advances in the molecular pathogenesis and cell therapy of stress urinary incontinence. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1090386"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Seval, M.M., and Koyuncu, K. (2022). Current status of stem cell treatments and innovative approaches for stress urinary incontinence. Front. Med., 9.","DOI":"10.3389\/fmed.2022.1073758"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ijgo.13769","article-title":"A systematic review of stem cell therapy treatment for women suffering from stress urinary incontinence","volume":"157","author":"Tamam","year":"2022","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.3727\/096368915X686229","article-title":"Regeneration of degenerated urinary sphincter muscles: Improved stem cell-based therapies and novel imaging technologies","volume":"24","author":"Amend","year":"2015","journal-title":"Cell Transplant."},{"key":"ref_93","first-page":"e11","article-title":"The frequency of metabolic syndrome in aged female patients (older than 65 years) with and without stress urinary incontinence: A case-control study","volume":"28","author":"Wang","year":"2022","journal-title":"Urogynecology"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Saravi, M.N., Mohseni, M., Oskouie, I.M., Razavi, J., Cidranes, E.D., and Zolbin, M.M. (2025). Exosome Therapy in Stress Urinary Incontinence: A Comprehensive Literature Review. Biomedicines, 13.","DOI":"10.3390\/biomedicines13051229"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-025-04220-w","article-title":"Progress of mesenchymal stem cells affecting extracellular matrix metabolism in the treatment of female stress urinary incontinence","volume":"16","author":"Fang","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Cheng, J., Hong, S., Yang, L., Liu, J., and Hong, L. (2021). Exosomes Secreted by M1-Type Macrophages Improve Stress Urinary Incontinence by Promoting the Repair of the Levator Ani Muscle Injury in Mice. Res. Sq.","DOI":"10.21203\/rs.3.rs-676443\/v1"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1089\/crispr.2020.0077","article-title":"Regenerating urethral striated muscle by CRISPRi\/dCas9-KRAB-mediated myostatin silencing for obesity-associated stress urinary incontinence","volume":"3","author":"Yuan","year":"2020","journal-title":"CRISPR J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00192-019-03867-3","article-title":"Stromal derived factor-1 plasmid as a novel injection for treatment of stress urinary incontinence in a rat model","volume":"31","author":"Khalifa","year":"2020","journal-title":"Int. Urogynecology J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s00192-021-05061-w","article-title":"Dimethyl fumarate ameliorates stress urinary incontinence by reversing ECM remodeling via the Nrf2-TGF-\u03b21\/Smad3 pathway in mice","volume":"33","author":"Liu","year":"2022","journal-title":"Int. Urogynecology J."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Tang, J., Liu, C., Li, B., Hong, S., Li, Q., Wang, L., Min, J., Hu, M., Li, Y., and He, S. (2019). Protective role of nuclear factor erythroid-2-related factor 2 against mechanical trauma-induced apoptosis in a vaginal distension-induced stress urinary incontinence mouse model. Oxidative Med. Cell. Longev., 2019.","DOI":"10.1155\/2019\/2039856"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Tan, X., Li, G., Li, C., Kong, C., Li, H., and Wu, S. (2024). Animal models, treatment options, and biomaterials for female stress urinary incontinence. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1414323"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Zhang, S., Yang, L., Hong, S., Liu, J., Cheng, J., He, Y., and Hong, L. (2023). Collagen type I\u2013loaded methacrylamide hyaluronic acid hydrogel microneedles alleviate stress urinary incontinence in mice: A novel treatment and prevention strategy. Colloids Surf. B Biointerfaces, 222.","DOI":"10.1016\/j.colsurfb.2022.113085"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"494","DOI":"10.21037\/tau-20-1217","article-title":"Progress in studies on pathological changes and future treatment strategies of obesity-associated female stress urinary incontinence: A narrative review","volume":"10","author":"Pan","year":"2021","journal-title":"Transl. Androl. Urol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Song, C., Xia, S., and Zhu, Y. (2024). MP23-17 low-intensity pulsed ultrasound promotes urethral smooth muscle regeneration by modulating the immune microenvironment. J. Urol., 211.","DOI":"10.1097\/01.JU.0001008776.99097.8a.17"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Wu, C., Tian, Y., Liu, T., An, S., Qian, Y., Gao, C., Yuan, J., Liu, M., Nie, M., and Jiang, W. (2025). Low-intensity pulsed ultrasound elevates blood pressure for shock. Sci. Adv., 11.","DOI":"10.1126\/sciadv.ads6947"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/jsxmed\/qdad166","article-title":"Efficacy and safety of a device that combines multipolar radiofrequency with pulsed electromagnetic field for the treatment of vulvovaginal atrophy: A randomized, sham-controlled trial","volume":"21","author":"Nappi","year":"2024","journal-title":"J. Sex. Med."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Huang, X., Scoles, S., Nguyen, P., Chen, J., Wisniewski, J., Wan, Y., and Jiang, G.J. (2024, January 20\u201324). Safety Assessment of Pulsed Electromagnetic Field Pelvic Floor Therapies with Implanted Sacral Neuromodulation Devices. Proceedings of the 2024 IEEE International Symposium on Electromagnetic Compatibility, Signal & Power Integrity (EMC+SIPI), Okinawa, Japan.","DOI":"10.1109\/EMCSIPI49824.2024.10705601"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"18","DOI":"10.14740\/wjnu432","article-title":"Efficacy of top flat magnetic stimulation technology for female stress and urge urinary incontinence: A clinical evaluation","volume":"11","author":"Biondo","year":"2022","journal-title":"World J. Nephrol. Urol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Kannan, P., Cheing, G.L., Fung, B.K.Y., Li, J., Leung, W.C., Chung, R.C., Cheung, T.W., Lam, L.F., Lee, W.Y., and Wong, W.C. (2022). Effectiveness of pelvic floor muscle training alone or combined with either a novel biofeedback device or conventional biofeedback for improving stress urinary incontinence: A randomized controlled pilot trial. Contemp. Clin. Trials, 123.","DOI":"10.1016\/j.cct.2022.106991"},{"key":"ref_110","first-page":"e668","article-title":"The use of platelet-rich plasma as a novel nonsurgical treatment of the female stress urinary incontinence: A prospective pilot study","volume":"27","author":"Athanasiou","year":"2021","journal-title":"Urogynecology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/nau.25365","article-title":"Autologous platelet rich plasma (A-PRP) combined with pelvic floor muscle training for the treatment of female stress urinary incontinence (SUI): A randomized control clinical trial","volume":"43","author":"Saraluck","year":"2024","journal-title":"Neurourol. Urodynamics"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Long, C.-Y., Lin, K.-L., Shen, C.-R., Ker, C.-R., Liu, Y.-Y., Loo, Z.-X., Hsiao, H.-H., and Lee, Y.-C. (2021). A pilot study: Effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence. Sci. Rep., 11.","DOI":"10.1038\/s41598-020-80598-2"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00404-019-05371-x","article-title":"Treatment of urinary incontinence in overweight women by a multidisciplinary lifestyle intervention","volume":"301","author":"Andreasen","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5114\/pm.2022.116437","article-title":"Impact of lifestyle and diet on endometriosis: A fresh look to a busy corner","volume":"21","author":"Habib","year":"2022","journal-title":"Menopausal Rev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00192-020-04516-w","article-title":"A randomized, intervention parallel multicentre study to evaluate duloxetine and innovative pelvic floor muscle training in women with uncomplicated stress urinary incontinence\u2014The DULOXING study","volume":"32","author":"Hagovska","year":"2021","journal-title":"Int. Urogynecology J."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Weinstein, M.M., Pulliam, S.J., and Richter, H.E. (2021). Randomized trial comparing efficacy of pelvic floor muscle training with a digital therapeutic motion-based device to standard pelvic floor exercises for treatment of stress urinary incontinence (SUV trial): An all-virtual trial design. Contemp. Clin. Trials, 105.","DOI":"10.1016\/j.cct.2021.106406"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Amira, N.A., Mamdouh, M.N., Dalia, M.K., and Mohamed, A.S.E. (2024). Effect of Kinesiotaping on Activation of Abdominal Muscles in Female Patients with Stress Urinary Incontinence: Narrative Review. Med. J. Cairo Univ., 92.","DOI":"10.21608\/mjcu.2024.411718"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/7\/1272\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:09:50Z","timestamp":1760033390000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/7\/1272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":117,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["medicina61071272"],"URL":"https:\/\/doi.org\/10.3390\/medicina61071272","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]}}}