{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:14:00Z","timestamp":1783091640143,"version":"3.54.6"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Nausea and vomiting (NV) are common and distressing adverse effects among cancer patients undergoing treatment. Despite the widespread use of pharmacological antiemetics, these medications are often insufficient for controlling nausea and may cause medication interactions and side effects. Acupuncture has been proposed as a complementary therapy; however, the comprehensive analysis of its effects on NV across all emetogenic cancer treatments remains limited. This systematic review and meta-analysis aimed to evaluate the effectiveness and safety of acupuncture in managing NV in cancer patients undergoing chemotherapy, radiotherapy, or surgery. Materials and Methods: We conducted a comprehensive search across three electronic databases and two clinical registry platforms from inception to December 2024. Randomized controlled trials (RCTs) evaluating acupuncture for NV in cancer patients were included. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Safety outcomes were assessed based on the Common Terminology Criteria for Adverse Events (CTCAE). Results: Seventeen RCTs met the inclusion criteria, with twelve studies included in the meta-analysis. Acupuncture did not demonstrate significant effects on acute nausea (RR: 0.98; 95% CI: 0.84\u20131.15; p = 0.80) or acute vomiting (RR: 0.93; 95% CI: 0.65\u20131.32; p = 0.67). However, it significantly reduced delayed vomiting (RR: 0.76; 95% CI: 0.61\u20130.95; p = 0.02). Subgroup analysis demonstrated significant effects when acupuncture was administered for at least five days (RR: 0.56; 95% CI: 0.39\u20130.81; p = 0.002). The most frequently used acupoints were PC6, ST36, CV12, LI4, LR3, and ST25. No serious adverse events related to acupuncture treatments were reported, with only minor AEs such as localized bleeding and mild bruising observed. Conclusions: Acupuncture represents a safe and effective complementary therapy for managing delayed vomiting in cancer patients receiving emetogenic treatments. Clinicians can anticipate optimal benefits from at least five days of treatment, particularly using acupoints PC6, ST36, CV12, LI4, LR3, and ST25. Further high-quality studies are needed to establish standardized treatment regimens and explore its comprehensive effects on NV.<\/jats:p>","DOI":"10.3390\/medicina61071287","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T10:33:47Z","timestamp":1752748427000},"page":"1287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and Safety of Acupuncture for Nausea and Vomiting in Cancer Patients: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0321-2351","authenticated-orcid":false,"given":"Sung-A","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"},{"name":"Epidemiology Group, Aberdeen Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen AB24 3FX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujung","family":"Yeo","sequence":"additional","affiliation":[{"name":"Research Institute of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0509-6681","authenticated-orcid":false,"given":"Sabina","family":"Lim","sequence":"additional","affiliation":[{"name":"Research Group of Pain and Neuroscience, WHO Collaborating Center for Traditional Medicine, East-West Medical Research Institute, Kyung Hee University, Seoul 02447, Republic of Korea"},{"name":"Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/bmj.1.6174.1323-a","article-title":"Incidence of nausea and vomiting with cytotoxic chemotherapy: A prospective randomised trial of antiemetics","volume":"1","author":"Morran","year":"1979","journal-title":"Br. Med. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/14740338.2020.1724955","article-title":"A multidisciplinary expert opinion on CINV and RINV, unmet needs and practical real-life approaches","volume":"19","author":"Bossi","year":"2020","journal-title":"Expert. Opin. Drug Saf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"883","DOI":"10.6004\/jnccn.2017.0117","article-title":"NCCN guidelines insights: Antiemesis, version 2.2017","volume":"15","author":"Berger","year":"2017","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1634\/theoncologist.7-1-65","article-title":"The cardiotoxic potential of the 5-HT(3) receptor antagonist antiemetics: Is there cause for concern?","volume":"7","author":"Keefe","year":"2002","journal-title":"Oncologist"},{"key":"ref_5","first-page":"297","article-title":"Acupuncture for nausea: How does it work?","volume":"142","author":"Samuels","year":"2003","journal-title":"Harefuah"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.autneu.2006.07.015","article-title":"Acupuncture for nausea and vomiting: An update of clinical and experimental studies","volume":"129","author":"Streitberger","year":"2006","journal-title":"Auton. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15347354211058207","DOI":"10.1177\/15347354211058207","article-title":"Prophylactic acupuncture treatment during chemotherapy in patients with breast cancer\u2013results of a qualitative study nested in a randomized pragmatic trial","volume":"20","author":"Kirschbaum","year":"2021","journal-title":"Integr. Cancer Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1002\/cncr.34165","article-title":"Safety of acupuncture in oncology: A systematic review and meta-analysis of randomized controlled trials","volume":"128","author":"Haller","year":"2022","journal-title":"Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kong, F., Wang, Z., Wang, N., Zhao, L., Mei, Q., Yu, Y., Zhang, D., Li, X., and Jia, Y. (2022). The clinical observation of acupuncture combined with antiemetic drugs in the prevention and treatment of CINV in breast cancer patients. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.888651"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez Garc\u00eda, E., Nishishinya Aquino, M.B., Cruz Mart\u00ednez, O., Ren, Y., Xia, R., Fei, Y., and Fern\u00e1ndez-Jan\u00e9, C. (2024). Efficacy and Safety of Acupuncture and Related Techniques in the Management of Oncological Children and Adolescent Patients: A Systematic Review. Cancers, 16.","DOI":"10.3390\/cancers16183197"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e31478","DOI":"10.1097\/MD.0000000000031478","article-title":"Acupuncture for cancer patients with nausea and vomiting: A protocol for systematic review and meta-analysis","volume":"102","author":"Kim","year":"2023","journal-title":"Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"ST-1","DOI":"10.1089\/acm.2010.1610","article-title":"Revised standards for reporting interventions in clinical trials of acupuncture (STRICTA): Extending the CONSORT statement","volume":"16","author":"MacPherson","year":"2010","journal-title":"J. Altern. Complement. Med."},{"key":"ref_13","first-page":"ED000142","article-title":"Updated guidance for trusted systematic reviews: A new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_14","unstructured":"Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V. (2019). Cochrane Handbook for Systematic Reviews of Interventions, Wiley."},{"key":"ref_15","first-page":"785","article-title":"Common terminology criteria for adverse events","volume":"784","author":"Shah","year":"2022","journal-title":"Natl. Cancer Inst. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1001\/jama.284.21.2755","article-title":"Electroacupuncture for control of myeloablative chemotherapy-induced emesis: A randomized controlled trial","volume":"284","author":"Shen","year":"2000","journal-title":"JAMA"},{"key":"ref_17","first-page":"2538","article-title":"Effect of acupuncture compared with placebo-acupuncture at P6 as additional antiemetic prophylaxis in high-dose chemotherapy and autologous peripheral blood stem cell transplantation: A randomized controlled single-blind trial","volume":"9","author":"Streitberger","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jpainsymman.2006.09.016","article-title":"Symptom Management with Massage and Acupuncture in Postoperative Cancer Patients: A Randomized Controlled Trial","volume":"33","author":"Mehling","year":"2007","journal-title":"J. Pain Symptom Manag."},{"key":"ref_19","first-page":"955","article-title":"Electroacupuncture at Zusanli (ST 36) for treatment of nausea and vomiting caused by the chemotherapy of the malignant tumor: A multicentral randomized controlled trial","volume":"29","author":"Yang","year":"2009","journal-title":"Zhongguo Zhen Jiu Chin. Acupunct. Moxibustion"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/annonc\/mdr402","article-title":"Acupuncture compared with placebo acupuncture in radiotherapy-induced nausea-A randomized controlled study","volume":"23","author":"Enblom","year":"2012","journal-title":"Ann. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/acu.2012.0876","article-title":"Electroacupuncture for nausea, vomiting, and myelosuppression in women receiving adjuvant Chemotherapy for Early Breast Cancer: A Randomized Controlled Pilot Trial","volume":"24","author":"Beith","year":"2012","journal-title":"Med. Acupunct."},{"key":"ref_22","first-page":"1061","article-title":"Effects of electroacupuncture on chemotherapy-induced nausea and vomiting and its mechanism","volume":"34","author":"Zhang","year":"2014","journal-title":"Zhongguo Zhen Jiu Chin. Acupunct. Moxibustion"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/acupmed-2015-010781","article-title":"EA versus sham acupuncture and no acupuncture for the control of acute and delayed chemotherapy-induced nausea and vomiting: A pilot study","volume":"33","author":"McKeon","year":"2015","journal-title":"Acupunct. Med. J. Br. Med. Acupunct. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ygyno.2014.10.025","article-title":"Efficacy of acupuncture in prevention of delayed chemotherapy induced nausea and vomiting in gynecologic cancer patients","volume":"136","author":"Rithirangsriroj","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_25","first-page":"797","article-title":"Electroacupuncture Treatment Conduced Before and After Surgery Is Better in Promoting Reco-very of Gastrointestinal Function in Colorectal Cancer Patients Undergoing Radical Resection","volume":"43","author":"Wang","year":"2018","journal-title":"Zhen Ci Yan Jiu Acupunct. Res."},{"key":"ref_26","first-page":"1269","article-title":"Effect of acupuncture in different time on nausea and vomiting induced by chemotherapy of lung cancer","volume":"39","author":"Wang","year":"2019","journal-title":"Zhongguo Zhen Jiu Chin. Acupunct. Moxibust."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13020-020-00333-x","article-title":"Efficacy of acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancer: A multi-center, single-blind, randomized, sham-controlled clinical research","volume":"15","author":"Li","year":"2020","journal-title":"Chin. Med."},{"key":"ref_28","first-page":"7965","article-title":"The effects of acupuncture at different intervention time points on nausea and vomiting caused by cisplatin chemotherapy in patients with lung cancer","volume":"13","author":"Cheng","year":"2020","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"688727","DOI":"10.1155\/2022\/9688727","article-title":"Effect of Acupuncture on Delayed Emesis for the Patients Who Received High-Emetogenic Chemotherapy with Standard Antiemetic Prophylaxis (KHMC-HO-01): An Open-Label, Randomized Study","volume":"2022","author":"Maeng","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/acu.2021.0060","article-title":"Efficacy of Press Needle at PC6 Neiguan and ST36 Zusanli as Adjuvant Therapy in Reducing Symptoms of Chemotherapy-Induced Nausea and Vomiting in Pediatric Cancer Patients Undergoing Chemotherapy","volume":"34","author":"Bintoro","year":"2022","journal-title":"Med. Acupunct."},{"key":"ref_31","first-page":"560","article-title":"Auriculotherapy and acupuncture treatments for chemotherapy-induced nausea and vomiting: A multicenter clinical trial","volume":"32","author":"Ma","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1200\/JCO.24.00099","article-title":"Effect of Adding Electroacupuncture to Standard Triple Antiemetic Therapy on Chemotherapy-Induced Nausea and Vomiting: A Randomized Controlled Clinical Trial","volume":"42","author":"Shen","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_33","unstructured":"World Health Organization, Regional Office for the Western Pacific (2008). WHO Standard Acupuncture Point Locations in the Western Pacific Region, World Health Organization."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"12504","DOI":"10.1002\/cam4.5962","article-title":"Acupuncture for the prevention of chemotherapy-induced nausea and vomiting in cancer patients: A systematic review and meta-analysis","volume":"12","author":"Yan","year":"2023","journal-title":"Cancer Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1056\/NEJMra1515442","article-title":"Antiemetic prophylaxis for chemotherapy-induced nausea and vomiting","volume":"374","author":"Navari","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Rapoport, B.L. (2017). Delayed chemotherapy-induced nausea and vomiting: Pathogenesis, incidence, and current management. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00019"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.eujim.2016.06.022","article-title":"The effects of acupuncture on serotonin metabolism","volume":"8","author":"Lee","year":"2016","journal-title":"Eur. J. Integr. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1525-1403.2010.00295.x","article-title":"Mechanism of acupuncture on neuromodulation in the gut\u2014A review","volume":"14","author":"Takahashi","year":"2011","journal-title":"Neuromodulation Technol. Neural Interface"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"154160","DOI":"10.1016\/j.phymed.2022.154160","article-title":"Acupuncture for cancer-related insomnia: A systematic review and meta-analysis","volume":"102","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"100970","DOI":"10.1016\/j.imr.2023.100970","article-title":"Acupuncture treatment for functional gastrointestinal disorders: Identification of major acupoints using network analysis","volume":"12","author":"Moon","year":"2023","journal-title":"Integr. Med. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41586-021-04001-4","article-title":"A neuroanatomical basis for electroacupuncture to drive the vagal\u2013adrenal axis","volume":"598","author":"Liu","year":"2021","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Mosa, A.S.M., Hossain, A.M., Lavoie, B.J., and Yoo, I. (2020). Patient-Related Risk Factors for Chemotherapy-Induced Nausea and Vomiting: A Systematic Review. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00329"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1534735420949679","DOI":"10.1177\/1534735420949679","article-title":"The effects of acupuncture on cancer-related fatigue: Updated systematic review and meta-analysis","volume":"19","author":"Jang","year":"2020","journal-title":"Integr. Cancer Ther."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Chan, M.W., Wu, X.Y., Wu, J.C., Wong, S.Y., and Chung, V.C. (2017). Safety of acupuncture: Overview of systematic reviews. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-03272-0"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.imr.2020.01.003","article-title":"Is acupuncture dose dependent? Ramifications of acupuncture treatment dose within clinical practice and trials","volume":"9","author":"Bauer","year":"2020","journal-title":"Integr. Med. Res."},{"key":"ref_46","first-page":"1533","article-title":"Anticipatory nausea and vomiting","volume":"19","author":"Roscoe","year":"2011","journal-title":"Support. Care Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cct.2003.10.016","article-title":"Assessment of blinding in clinical trials","volume":"25","author":"Bang","year":"2004","journal-title":"Control. Clin. Trials"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/7\/1287\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:11:19Z","timestamp":1760033479000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/7\/1287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["medicina61071287"],"URL":"https:\/\/doi.org\/10.3390\/medicina61071287","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]}}}