{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:55:37Z","timestamp":1793904937017,"version":"4.8.0"},"reference-count":75,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Statins are among the most prescribed medications globally, primarily due to their potent lipid-lowering capabilities. This systematic review aims to identify, synthesize and evaluate current evidence regarding the potential protective effects of statins on sepsis mortality. Materials and Methods: A thorough and comprehensive database search was conducted in PubMed and Cochrane Library until 30 January 2025. Randomized control trials (RCTs) and cohort studies evaluating the effect of statin use on sepsis mortality were included. Risk-ratios (RRs) and 95% confidence intervals (CIs) were calculated. Statistical analysis and forest plot generation were performed using RevMan 5.4. Risk of bias was assessed using the RoB-2 and NOS tools. Results: A total of 49 studies were identified following application of the PRISMA guidelines. Of these, 16 studies were RCTs and 33 were cohort studies. The pooled analysis of RCTs demonstrated a non-significant 10% reduction in mortality in statin users (RR: 0.90, 95% CI 0.80\u20131.01). The pooled analysis of cohort studies showed that statin users have a 21% significantly reduced mortality risk (RR: 0.79, 95% CI 0.72\u20130.86). For the de novo statin users vs non-statin users, pooled analysis demonstrated a significant 25% reduction in mortality (RR: 0.75, 95% CI 0.69\u20130.81). The pooled analysis for the continuation of prior statin use vs discontinuation of statin use indicated 52% lower mortality in statin users who continued the use of statins (RR: 0.48, 95% CI 0.25\u20130.92). The pooled analysis of prior statin use and continuation of statins vs non-statin use revealed a significant 23% lower risk in statin users compared with non-statin users (RR: 0.77, 95% CI 0.69\u2013086). Conclusions: According to our findings, statin use among septic patients is associated with a reduction in mortality, suggesting that statins may offer a beneficial therapeutic effect in the clinical setting. Clinicians may consider the continuation or potential incorporation of statin use as an additional regimen in the treatment of septic patients.<\/jats:p>","DOI":"10.3390\/medicina61091563","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T08:28:15Z","timestamp":1756715295000},"page":"1563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Impact of Statin Use on Sepsis Mortality: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"61","author":[{"given":"Constantinos","family":"Philippou","sequence":"first","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-8529","authenticated-orcid":false,"given":"Constantinos","family":"Tsioutis","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tsiappari","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6981-8535","authenticated-orcid":false,"given":"Nikolaos","family":"Spernovasilis","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"},{"name":"Department of Infectious Diseases, German Medical Institute, Limassol 4108, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-5075","authenticated-orcid":false,"given":"Aris P.","family":"Agouridis","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"},{"name":"Department of Internal Medicine, German Medical Institute, Limassol 4108, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: Analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/epidemiologia5030032","article-title":"The Global Burden of Sepsis and Septic Shock","volume":"5","author":"Sangiorgio","year":"2024","journal-title":"Epidemiologia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2174\/1381612822666151109111511","article-title":"All for Statins and Statins for All; An Update","volume":"22","author":"Agouridis","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1582-4934.2001.tb00172.x","article-title":"Statins: Mechanism of action and effects","volume":"5","author":"Stancu","year":"2001","journal-title":"J. Cell. Mol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.amjcard.2014.02.034","article-title":"Meta-analysis of time-related benefits of statin therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention","volume":"113","author":"Navarese","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wang, W., and Zhang, B. (2014). Statins for the prevention of stroke: A meta-analysis of randomized controlled trials. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0092388"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/1074248408318628","article-title":"An overview of the extra-lipid effects of rosuvastatin","volume":"13","author":"Kostapanos","year":"2008","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_9","first-page":"921","article-title":"Statin therapy in critically-ill patients with severe sepsis: A review and meta-analysis of randomized clinical trials","volume":"81","author":"Thomas","year":"2015","journal-title":"Minerva Anestesiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"656.e7","DOI":"10.1016\/j.jcrc.2010.02.013","article-title":"The effect of statins on mortality from severe infections and sepsis: A systematic review and meta-analysis","volume":"25","author":"Janda","year":"2010","journal-title":"J. Crit. Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1093\/jac\/dkn019","article-title":"Statins for infection and sepsis: A systematic review of the clinical evidence","volume":"61","author":"Falagas","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/cc13828","article-title":"Effect of statin therapy on mortality from infection and sepsis: A meta-analysis of randomized and observational studies","volume":"18","author":"Wan","year":"2014","journal-title":"Crit. Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.4103\/0972-5229.190366","article-title":"Systematic review of statins in sepsis: There is no evidence of dose response","volume":"20","author":"Quinn","year":"2016","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cmi.2018.11.003","article-title":"Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults\u2014A systematic review and meta-analysis","volume":"25","author":"Pertzov","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00134-009-1429-0","article-title":"The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: A randomized double-blind placebo controlled clinical trial","volume":"35","author":"Novack","year":"2009","journal-title":"Intensive Care Med."},{"key":"ref_17","first-page":"113","article-title":"Effect of statin therapy in early sepsis: Effect on endothelial function and prognostic implication","volume":"78","author":"Zaghla","year":"2010","journal-title":"Med. J. Cairo Univ."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1164\/rccm.201006-0955OC","article-title":"Continuation of statin therapy in patients with presumed infection: A randomized controlled trial","volume":"183","author":"Kruger","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1097\/CCM.0b013e318225742c","article-title":"Effect of pravastatin on the frequency of ventilator-associated pneumonia and on intensive care unit mortality: Open-label, randomized study","volume":"39","author":"Makris","year":"2011","journal-title":"Crit. Care Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"R231","DOI":"10.1186\/cc11895","article-title":"Randomized double-blind placebo-controlled trial of 40 mg\/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial)","volume":"16","author":"Patel","year":"2012","journal-title":"Crit. Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"P61","DOI":"10.1186\/cc11999","article-title":"A clinical randomized trial on the use of atorvastatin in patients with sepsis or septic shock: Effects on endothelial function","volume":"17","author":"Prado","year":"2013","journal-title":"Crit. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1164\/rccm.201209-1718OC","article-title":"A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis","volume":"187","author":"Kruger","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1001\/jama.2013.280031","article-title":"Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: A randomized clinical trial","volume":"310","author":"Papazian","year":"2013","journal-title":"JAMA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.egja.2014.02.005","article-title":"Safety and vasopressor effect of rosuvastatin in septic patients","volume":"30","author":"Elsharnouby","year":"2014","journal-title":"Egypt. J. Anaesth."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1056\/NEJMoa1401520","article-title":"Rosuvastatin for sepsis-associated acute respiratory distress syndrome","volume":"370","author":"Truwit","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1403285","article-title":"Simvastatin in the acute respiratory distress syndrome","volume":"371","author":"McAuley","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e006251","DOI":"10.1136\/bmjopen-2014-006251","article-title":"The effect of simvastatin on inflammatory cytokines in community-acquired pneumonia: A randomised, double-blind, placebo-controlled trial","volume":"5","author":"Viasus","year":"2015","journal-title":"BMJ Open"},{"key":"ref_28","first-page":"1203","article-title":"The effect of simvastatinon the outcome of patients with sepsis: A clinical trial study","volume":"32","author":"Mirjalili","year":"2016","journal-title":"Acta Medica Mediterr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"646","DOI":"10.4103\/ijccm.IJCCM_474_16","article-title":"The Effects of Atorvastatin on Inflammatory Responses and Mortality in Septic Shock: A Single-center, Randomized Controlled Trial","volume":"21","author":"Singh","year":"2017","journal-title":"Indian. J. Crit. Care Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S375","DOI":"10.1016\/j.jval.2019.04.1832","article-title":"PSY7 Cost-Effective Analysis for Simvastatin Plus Standard Therapy Versus Standard Therapy Alone in Critically Ill Septic Patients","volume":"22","author":"Eladawy","year":"2019","journal-title":"Value Health"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1164\/rccm.201812-2328OC","article-title":"Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial","volume":"200","author":"Sapey","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1086\/323334","article-title":"The effect of statins on mortality in patients with bacteremia","volume":"33","author":"Liappis","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1097\/01.CCM.0000207345.92928.E4","article-title":"Statin use and mortality within 180 days after bacteremia: A population-based cohort study","volume":"34","author":"Thomsen","year":"2006","journal-title":"Crit. Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1007\/s00134-006-0246-y","article-title":"Association of statin therapy and increased survival in patients with multiple organ dysfunction syndrome","volume":"32","author":"Schmidt","year":"2006","journal-title":"Intensive Care Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00134-005-2859-y","article-title":"Statin therapy is associated with fewer deaths in patients with bacteraemia","volume":"32","author":"Kruger","year":"2006","journal-title":"Intensive Care Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1592\/phco.27.1.20","article-title":"Effectiveness of statins in reducing the rate of severe sepsis: A retrospective evaluation","volume":"27","author":"Martin","year":"2007","journal-title":"Pharmacotherapy"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ajem.2006.09.011","article-title":"Statins do not improve short-term survival in an oriental population with sepsis","volume":"25","author":"Yang","year":"2007","journal-title":"Am. J. Emerg. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1592\/phco.29.6.621","article-title":"Reduction in mortality associated with statin therapy in patients with severe sepsis","volume":"29","author":"Dobesh","year":"2009","journal-title":"Pharmacotherapy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1177\/0310057X1103900611","article-title":"Effect of statins on the clinical outcomes of patients with sepsis","volume":"39","author":"Goodin","year":"2011","journal-title":"Anaesth. Intensive Care"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"R171","DOI":"10.1186\/cc10317","article-title":"Effects of discontinuing or continuing ongoing statin therapy in severe sepsis and septic shock: A retrospective cohort study","volume":"15","author":"Ouanes","year":"2011","journal-title":"Crit. Care"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1097\/CCM.0b013e31823bc9e7","article-title":"Statins and outcomes in patients with bloodstream infection: A propensity-matched analysis","volume":"40","author":"Leung","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/MEJ.0b013e32834b3467","article-title":"The association of prior statin use in septic shock treated with early goal directed therapy","volume":"19","author":"Fuller","year":"2012","journal-title":"Eur. J. Emerg. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s15010-011-0190-9","article-title":"The impact of prior long-term versus short-term statin use on the mortality of bacteraemic patients","volume":"40","author":"Nseir","year":"2012","journal-title":"Infection"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Cuervo, G., Garcia-Vidal, C., Nucci, M., Puchades, F., Fern\u00e1ndez-Ruiz, M., Mykietiuk, A., Manzur, A., Gudiol, C., Pem\u00e1n, J., and Viasus, D. (2013). Effect of statin use on outcomes of adults with candidemia. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0077317"},{"key":"ref_45","first-page":"102","article-title":"Statins decrease mortality in Lebanese patients with sepsis: A multicenter study","volume":"11","author":"Ajrouche","year":"2013","journal-title":"Pharm Pract."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Cort\u00e9s, L.E., G\u00e1lvez-Acebal, J., Del Toro, M.D., Velasco, C., de Cueto, M., Caballero, F.J., Muniain, M.A., Pascual, A., and Rodr\u00edguez-Ba\u00f1o, J. (2013). Effect of statin therapy in the outcome of bloodstream infections due to Staphylococcus aureus: A prospective cohort study. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0082958"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00134-014-3418-1","article-title":"Effect of the use of low and high potency statins and sepsis outcomes","volume":"40","author":"Ou","year":"2014","journal-title":"Intensive Care Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1177\/1060028015579987","article-title":"Continuation of Statin Therapy and Vasopressor Use in Septic Shock","volume":"49","author":"Zechmeister","year":"2015","journal-title":"Ann. Pharmacother."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Mansur, A., Steinau, M., Popov, A.F., Ghadimi, M., Beissbarth, T., Bauer, M., and Hinz, J. (2015). Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: A prospective observational cohort study. BMC Med., 13.","DOI":"10.1186\/s12916-015-0368-6"},{"key":"ref_50","first-page":"A16215","article-title":"Abstract 16215: Statin Use in Asymptomatic Patients With Sepsis and Elevated Troponin is Associated With Lower Risk of Mortality","volume":"134","author":"Mullis","year":"2016","journal-title":"Circulation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jcrc.2016.04.031","article-title":"The association between prior statin use and long-term outcomes after critical care admission","volume":"35","author":"Beed","year":"2016","journal-title":"J. Crit. Care"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/SHK.0000000000000484","article-title":"Incidence of Sepsis and Mortality With Prior Exposure of HMG-COA Reductase Inhibitors in a Surgical Intensive Care Population","volume":"45","author":"Schurr","year":"2016","journal-title":"Shock"},{"key":"ref_53","first-page":"Oc17","article-title":"Sepsis Mortality in Critical Care and Prior Statin Therapy: A Retrospective Cohort Study in Central Argentina","volume":"11","author":"Paricahua","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/bja\/aex294","article-title":"Preadmission statin use improves the outcome of less severe sepsis patients\u2014A population-based propensity score matched cohort study","volume":"119","author":"Lee","year":"2017","journal-title":"Br. J. Anaesth."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e02228-16","DOI":"10.1128\/AAC.02228-16","article-title":"Evidence To Support Continuation of Statin Therapy in Patients with Staphylococcus aureus Bacteremia","volume":"61","author":"Caffrey","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2050312118801707","DOI":"10.1177\/2050312118801707","article-title":"Improved survival with continuation of statins in bacteremic patients","volume":"6","author":"Pawar","year":"2018","journal-title":"SAGE Open Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13613-017-0349-3","article-title":"The host response in critically ill sepsis patients on statin therapy: A prospective observational study","volume":"8","author":"Wiewel","year":"2018","journal-title":"Ann. Intensive Care"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Huang, T.M., Wu, V.C., Lin, Y.F., Wang, J.J., Shiao, C.C., Chen, L., Chueh, S.J., Chueh, E., Yang, S.Y., and Lai, T.S. (2018). Effects of Statin Use in Advanced Chronic Kidney Disease Patients. J. Clin. Med., 7.","DOI":"10.3390\/jcm7090285"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1177\/0300060519856137","article-title":"Impact of prior statin use on mortality in patients with type 2 diabetes mellitus and bloodstream infection","volume":"47","author":"Cheng","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/phar.2506","article-title":"The impact of statin use prior to intensive care unit admission on critically ill patients with sepsis","volume":"41","author":"Chinaeke","year":"2021","journal-title":"Pharmacotherapy"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Van de Louw, A., Cohrs, A., and Leslie, D. (2021). Effects of Statins on the Incidence and Mortality of Sepsis in Patients with New Cancer Diagnosis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10153427"},{"key":"ref_62","first-page":"7127531","article-title":"Statin Use and Mortality among Patients Hospitalized with Sepsis: A Retrospective Cohort Study within Southern California, 2008\u20132018","volume":"2022","author":"Liang","year":"2022","journal-title":"Crit Care Res Pract."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Yao, Y., Zhao, X., Wang, M., Zhou, F., Li, C., Le, X., and Zhang, S. (2024). Association between the use of statins and in-hospital mortality risk in patients with sepsis-induced coagulopathy during ICU stays: A study based on medical information mart for intensive care database. BMC Infect. Dis., 24.","DOI":"10.1186\/s12879-024-09636-y"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e915","DOI":"10.1016\/j.jacl.2024.07.006","article-title":"The impact of statin use on sepsis mortality","volume":"18","author":"Li","year":"2024","journal-title":"J. Clin. Lipidol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.amjmed.2014.10.057","article-title":"Statin therapy and mortality from sepsis: A meta-analysis of randomized trials","volume":"128","author":"Deshpande","year":"2015","journal-title":"Am. J. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3810\/pgm.2014.11.2832","article-title":"Impact of statins in outcomes of septic patients: A systematic review","volume":"126","author":"Salluh","year":"2014","journal-title":"Postgrad. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/bja\/ael358","article-title":"Beneficial effects of statins on the microcirculation during sepsis: The role of nitric oxide","volume":"98","author":"McGown","year":"2007","journal-title":"Br. J. Anaesth."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.bcp.2007.01.013","article-title":"Improved endothelial function and reduced platelet activation by chronic HMG-CoA-reductase inhibition with rosuvastatin in rats with streptozotocin-induced diabetes mellitus","volume":"73","author":"Fraccarollo","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1365-2125.2005.02568.x","article-title":"Reduction of oxidative stress and modulation of autoantibodies against modified low-density lipoprotein after rosuvastatin therapy","volume":"61","author":"Resch","year":"2006","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1161\/01.CIR.0000086460.55494.AF","article-title":"Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin","volume":"108","author":"Kleemann","year":"2003","journal-title":"Circulation"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1161\/01.ATV.0000151647.14923.ec","article-title":"Statins and blood coagulation","volume":"25","author":"Undas","year":"2005","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/01.ATV.0000161926.43967.df","article-title":"Rosuvastatin reduces platelet activation in heart failure: Role of NO bioavailability","volume":"25","author":"Fraccarollo","year":"2005","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.neuroscience.2005.04.063","article-title":"Post-ischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice via inhibition of extracellular-regulated kinase-1\/-2","volume":"134","author":"Kilic","year":"2005","journal-title":"Neuroscience"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pharmthera.2006.03.003","article-title":"Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions","volume":"112","author":"Shitara","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11883-017-0682-x","article-title":"Clinical Guidance for Managing Statin and Antimicrobial Drug-Drug Interactions","volume":"19","author":"Flurie","year":"2017","journal-title":"Curr. Atheroscler. 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