{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:02:42Z","timestamp":1787724162935,"version":"build-2784847793"},"reference-count":73,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research and Development Agency (in Spanish, ANID) of Chile","award":["11220035"],"award-info":[{"award-number":["11220035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: This systematic review and meta-analysis aimed to analyze the available body of published peer-reviewed randomized controlled trials (RCTs) on the effects of concurrent training (CT) on biomarkers, morphological variables, and physical performance in people with sarcopenic obesity. Materials and Methods: Using six databases\u2014PubMed, Medline, CINAHL Complete, Scopus, Cochrane Library, and Web of Science\u2014a comprehensive literature search was conducted through July 2025. The GRADE, TESTEX, Rob 2, and PRISMA tools were used to assess the methodological quality and certainty. The protocol was registered in PROSPERO (CRD420251052935). Results: Out of 669 records, 8 RCTs with a total of 453 participants (68.9 \u00b1 11.1 years) were included. Fifteen overall and three subgroup meta-analyses revealed significant improvements (p &lt; 0.05) in insulin-like growth factor-1 (ES = 1.01, 95% CI = 0.26 to 1.75, p = 0.008) and leptin (ES = 2.54, 95% CI = 0.07 to 5.01, p = 0.04) levels; significant decreases (p &lt; 0.05) in body mass index (ES = 0.54, 95% CI = 0.12 to 0.97, p = 0.01), waist circumference (ES = 1.80, 95% CI = 0.32 to 2.12, p = 0.008), and body fat (BF, ES = 1.31, 95% CI = 0.53 to 2.09, p = 0.001); and significantly increased (p &lt; 0.05) appendicular skeletal muscle mass\/weight (ES = 0.42, 95% CI = 0.14 to 0.71, p = 0.004), walking speed (ES = 1.80, 95% CI = 1.05 to 2.55, p = 0.000), and knee extension (ES = 0.76, 95% CI = 0.09 to 1.42, p = 0.02). However, no significant improvements (p &gt; 0.05) were observed in IL-6, CRP, total cholesterol, triglycerides, trunk fat, BF mass, and MIHS. On the other hand, an important result in the meta-regression revealed that weeks of training can predict decreases in BF (R2 = 0.32; p = 0.02). Conclusions: CT has been associated with significant clinical improvements in biomarkers related to increased muscle mass and decreased BF percentage.<\/jats:p>","DOI":"10.3390\/medicina61091697","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T14:45:46Z","timestamp":1758206746000},"page":"1697","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Concurrent Training on Biomarkers, Morphological Variables, and Physical Performance in People with Sarcopenic Obesity: A Meta-Analysis with Meta-Regression"],"prefix":"10.3390","volume":"61","author":[{"given":"Jordan","family":"Hernandez-Martinez","sequence":"first","affiliation":[{"name":"Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile"},{"name":"Department of Education, Faculty of Humanities, Universidad de la Serena, La Serena 1700000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5359-6587","authenticated-orcid":false,"given":"Edgar","family":"V\u00e1squez-Carrasco","sequence":"additional","affiliation":[{"name":"School of Occupational Therapy, Faculty of Psychology, Universidad de Talca, Talca 3465548, Chile"},{"name":"Centro de Investigaci\u00f3n en Ciencias Cognitivas, Faculty of Psychology, Universidad de Talca, Talca 3465548, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-867X","authenticated-orcid":false,"given":"Izham","family":"Cid-Calfucura","sequence":"additional","affiliation":[{"name":"Department of Physical Activity, Sports and Health Sciences, Faculty of Medical Sciences, Universidad de Santiago de Chile (USACH), Santiago 8370003, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3184-6482","authenticated-orcid":false,"given":"Cristian","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Escuela de Tecnolog\u00eda M\u00e9dica, Facultad de Salud, Universidad Santo Tom\u00e1s, Los Carreras 753, Osorno 5310431, Chile"},{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-5896","authenticated-orcid":false,"given":"Tom\u00e1s","family":"Herrera-Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Physical Activity, Sports and Health Sciences, Faculty of Medical Sciences, Universidad de Santiago de Chile (USACH), Santiago 8370003, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-7062","authenticated-orcid":false,"given":"Cristian","family":"N\u00fa\u00f1ez-Espinosa","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad de Magallanes, Punta Arenas 6200000, Chile"},{"name":"Centro Asistencial Docente e Investigaci\u00f3n, Universidad de Magallanes, Punta Arenas 6200000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-9128","authenticated-orcid":false,"given":"Braulio Henrique Magnani","family":"Branco","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Promotion, Cesumar University (UniCesumar), Maring\u00e1 87050-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-8280","authenticated-orcid":false,"given":"Pablo","family":"Vald\u00e9s-Badilla","sequence":"additional","affiliation":[{"name":"Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Cat\u00f3lica del Maule, Talca 3530000, Chile"},{"name":"Sports Coach Career, Faculty of Life Sciences, Universidad Vi\u00f1a del Mar, Vi\u00f1a del Mar 2520000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s11357-024-01245-6","article-title":"Body composition and aging: Cross-sectional results from the INSPIRE study in people 20 to 93 years old","volume":"47","author":"Briand","year":"2025","journal-title":"GeroScience"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000521241","article-title":"Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement","volume":"15","author":"Donini","year":"2022","journal-title":"Obes. 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