{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T03:28:32Z","timestamp":1794281312441,"version":"4.9.0"},"reference-count":59,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Multiple primary malignancies involving endometrial carcinoma (EC) present complex diagnostic and management challenges. This study aimed to identify clinical, pathological, and demographic patterns among patients with EC and a second primary tumor and assess the role of comorbidities in tumor behavior. Materials and Methods: We retrospectively analyzed 35 women diagnosed with EC and a second malignancy between 2017 and 2024. We evaluated clinical variables, tumor characteristics, and comorbidities. Statistical analysis included chi-square tests, Mann\u2013Whitney U tests, Kruskal\u2013Wallis tests, Spearman correlations, and logistic regression. Multiple testing correction was applied using the Benjamini\u2013Hochberg method. Results: Endometrioid EC was the most prevalent subtype (80%), most frequently associated with breast (28.5%) and colorectal cancers (11.4%). Obesity (45.7%), hypertension (62.9%), and diabetes (22.9%) were common. While univariate analysis suggested associations between comorbidities and tumor features (e.g., obesity and tumor type, \u03c1 = 0.30, p = 0.08), no correlation remained significant after adjustment. Logistic regression identified age (OR = 0.88, CI: 0.79\u20130.98, p = 0.022) and obesity (OR = 0.11, CI: 0.01\u20130.83, p = 0.033) as independent predictors of non-endometrioid histology. Conclusions: These findings suggest that age and obesity may influence histological differentiation in EC with multiple primaries. This study suggest that age and obesity may play a role in the histological differentiation of EC in patients with multiple primary tumors. The small cohort size (n = 35) limits the statistical power and generalizability of the results; therefore, they should be regarded as exploratory and hypothesis-generating, warranting validation in larger prospective studies.<\/jats:p>","DOI":"10.3390\/medicina61101748","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:05:13Z","timestamp":1758801913000},"page":"1748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endometrial Carcinoma and Associated Secondary Neoplasia: The Role of Clinical Features, Pathology, and Comorbidities in a University-Affiliated Clinical Center from Western Romania"],"prefix":"10.3390","volume":"61","author":[{"given":"Ioana","family":"Hurmuz","sequence":"first","affiliation":[{"name":"Department of Microscopic Morphology-Anatomic Pathology, ANAPATMOL Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-969X","authenticated-orcid":false,"given":"Robert","family":"Barna","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Anatomic Pathology, ANAPATMOL Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Natar\u00e2\u0219","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Anatomic Pathology, ANAPATMOL Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuliana-Anamaria","family":"Tr\u0103il\u0103","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Anatomic Pathology, ANAPATMOL Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisa","family":"Anderco","sequence":"additional","affiliation":[{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-3718","authenticated-orcid":false,"given":"Sorin","family":"Dema","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Emergency City Clinical Hospital Timisoara, 300079 Timisoara, Romania"},{"name":"Department of Oncology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-795X","authenticated-orcid":false,"given":"Aura","family":"Jurescu","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Anatomic Pathology, ANAPATMOL Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2291-4917","authenticated-orcid":false,"given":"Dorela-Codru\u021ba","family":"L\u0103zureanu","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Anatomic Pathology, ANAPATMOL Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorina","family":"T\u0103ban","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Anatomic Pathology, ANAPATMOL Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alis","family":"Dema","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Anatomic Pathology, ANAPATMOL Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timisoara, 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